CHRNA4 and UBQLN1

Number of citations of the paper that reports this interaction (PMID 16091357)
18

Data Source:
HPRD (in vivo)

		CHRNA4	UBQLN1
Gene Name		cholinergic receptor, nicotinic, alpha 4 (neuronal)	ubiquilin 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane	Proteasome Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding	Protein Binding Kinase Binding Protein Domain Specific Binding
	Biological Process	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Respiratory Gaseous Exchange Locomotory Behavior Regulation Of Dopamine Secretion Sensory Perception Of Pain Response To Nicotine Behavioral Response To Nicotine Exploration Behavior B Cell Activation Regulation Of Membrane Potential Neurological System Process Cognition Membrane Depolarization Regulation Of Inhibitory Postsynaptic Membrane Potential Cation Transmembrane Transport	Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs		Nicotine Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Galantamine Primidone Methylphenobarbital Phenobarbital Varenicline Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative
Diseases
GWAS		Chronic obstructive pulmonary disease ( 19300482)
Protein-Protein Interactions		7 interactors: CHRNB2 CHRNB4 CRELD2 CSNK2B UBQLN1 VSNL1 YWHAH	151 interactors: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 APP ASCL1 ATXN3 BPIFA1 C1QA C1QTNF2 CALU CARKD CCL7 CCNB1 CD47 CD99 CD99L2 CHGB CHRNA3 CHRNA4 CHRNB4 COL10A1 COL1A2 COLGALT2 COMTD1 CSTF2 CSTF2T CTAG1B CTAG2 CYB5R1 DEFA6 DNAJB2 EFEMP2 EP300 EPS15 ERP27 ETNK1 F8 FAM127A FAM127B FAM127C FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GHRL GIT2 GKAP1 GPX3 GRM2 GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 KLHL42 LITAF MANBAL MCM7 MIEF1 MIEF2 MLLT6 MTOR NBL1 NDE1 NGLY1 NME3 NPPA NPY NUPL1 P4HB PBXIP1 PIK3IP1 PLA2G16 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PSEN1 PSEN2 PSMD4 PSMD6 PTN RARA RASSF5 RIC8A RNF208 RPN1 RSRC2 SCG5 SCMH1 SERPINE1 SERPINI2 SIL1 SLC29A2 SMAD9 SMIM2 SMR3B SPARC SRGN STMN3 TARDBP TFF1 TICAM1 TMCO6 TMEM31 TMEM37 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM32 TXNDC12 UBB UBC UBE2V1 UBQLN4 UBXN1 UBXN4 VCP XPO4 ZFAND2B ZG16 ZG16B ZMYM4 ZNF343
Entrez ID		1137	29979
HPRD ID		00333	05440
Ensembl ID		ENSG00000101204	ENSG00000135018
Uniprot IDs		B4DK78 P43681 Q4VAQ3 Q4VAQ5 Q59FV0	Q9UMX0
PDB IDs		2GVT 2LLY	2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Micturition Action Potential Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Membrane Potential Response To Nicotine Regulation Of Synaptic Transmission Excretion Neural Nucleus Development Smooth Muscle Contraction Regulation Of Dendrite Morphogenesis Regulation Of Signaling Renal System Process Lateral Geniculate Nucleus Development Glucocorticoid Catabolic Process Regulation Of Dendrite Development Membrane Depolarization Cellular Response To Stimulus Response To Alkaloid Adult Behavior Negative Regulation Of Action Potential Muscle Contraction Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Locomotory Behavior Regulation Of Cellular Localization Conditioned Taste Aversion Response To Stimulus Muscle System Process Positive Regulation Of Activin Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Dendrite Morphogenesis Response To Hypoxia Vestibulocochlear Nerve Development Positive Regulation Of Synaptic Transmission, Dopaminergic Optic Nerve Morphogenesis Signal Transduction Endothelial Tube Morphogenesis Positive Regulation Of Catecholamine Secretion Optic Nerve Development Signaling Regulation Of Neuron Projection Development Thalamus Development Cell Communication Negative Regulation Of Dendrite Development Glucocorticoid Metabolic Process	Response To Stress Response To Organic Substance Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Histamine Cellular Response To Organic Substance Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Platelet Degranulation Signal Transduction Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of ERBB Signaling Pathway Response To Histamine Chloride Transmembrane Transport Response To Organic Cyclic Compound Positive Regulation Of Protein Catabolic Process Signaling Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Gamma-aminobutyric Acid Signaling Pathway Response To Hypoxia Cell Communication Chloride Transport Notch Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cellular Response To Oxygen Levels Regulation Of Cellular Process Defense Response Positive Regulation Of Cell Cycle Cellular Response To Ammonium Ion Notch Receptor Processing Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		adrenal axis bcl1 beck besides carriers cc cholinergic depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Difference) ?		adrenal axis bcl1 beck besides carriers cc cholinergic depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Intersection) ?