CHRNA4 and CRELD2

Number of citations of the paper that reports this interaction (PMID 16238698)
7

Data Source:
HPRD (in vitro, two hybrid)

		CHRNA4	CRELD2
Gene Name		cholinergic receptor, nicotinic, alpha 4 (neuronal)	cysteine-rich with EGF-like domains 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane	Extracellular Space Endoplasmic Reticulum Golgi Apparatus
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding	Calcium Ion Binding Protein Binding
	Biological Process	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Respiratory Gaseous Exchange Locomotory Behavior Regulation Of Dopamine Secretion Sensory Perception Of Pain Response To Nicotine Behavioral Response To Nicotine Exploration Behavior B Cell Activation Regulation Of Membrane Potential Neurological System Process Cognition Membrane Depolarization Regulation Of Inhibitory Postsynaptic Membrane Potential Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs		Nicotine Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Galantamine Primidone Methylphenobarbital Phenobarbital Varenicline Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative
Diseases
GWAS		Chronic obstructive pulmonary disease ( 19300482)
Protein-Protein Interactions		7 interactors: CHRNB2 CHRNB4 CRELD2 CSNK2B UBQLN1 VSNL1 YWHAH	6 interactors: C8orf33 CDKN2A CHRNA4 CHRNB2 MEST SUV39H1
Entrez ID		1137	79174
HPRD ID		00333	08455
Ensembl ID		ENSG00000101204	ENSG00000184164
Uniprot IDs		B4DK78 P43681 Q4VAQ3 Q4VAQ5 Q59FV0	Q6UXH1
PDB IDs		2GVT 2LLY
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Involved In Micturition Micturition Action Potential Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Membrane Potential Response To Nicotine Regulation Of Synaptic Transmission Excretion Neural Nucleus Development Smooth Muscle Contraction Regulation Of Dendrite Morphogenesis Regulation Of Signaling Renal System Process Lateral Geniculate Nucleus Development Glucocorticoid Catabolic Process Regulation Of Dendrite Development Membrane Depolarization Cellular Response To Stimulus Response To Alkaloid Adult Behavior Negative Regulation Of Action Potential Muscle Contraction Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Locomotory Behavior Regulation Of Cellular Localization Conditioned Taste Aversion Response To Stimulus Muscle System Process Positive Regulation Of Activin Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Dendrite Morphogenesis Response To Hypoxia Vestibulocochlear Nerve Development Positive Regulation Of Synaptic Transmission, Dopaminergic Optic Nerve Morphogenesis Signal Transduction Endothelial Tube Morphogenesis Positive Regulation Of Catecholamine Secretion Optic Nerve Development Signaling Regulation Of Neuron Projection Development Thalamus Development Cell Communication Negative Regulation Of Dendrite Development Glucocorticoid Metabolic Process	Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Response To Hypoxia Response To Nicotine Regulation Of B Cell Proliferation Action Potential Sensory Perception Of Pain Regulation Of Circadian Rhythm Lateral Geniculate Nucleus Development Membrane Depolarization RRNA Processing RRNA Metabolic Process Regulation Of Anion Transport Response To Alkaloid B Cell Activation Adult Behavior Senescence-associated Heterochromatin Focus Assembly Synaptic Transmission Involved In Micturition Ribosome Biogenesis Regulation Of Cellular Localization Negative Regulation Of Action Potential Positive Regulation Of Cellular Senescence Response To Abiotic Stimulus Locomotory Behavior Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Regulation Of Membrane Potential Negative Regulation Of Immature T Cell Proliferation In Thymus Histone H3-K9 Dimethylation Micturition Conditioned Taste Aversion Cognition Positive Regulation Of Macrophage Apoptotic Process Calcium Ion Transport Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Cell Aging Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Ribonucleoprotein Complex Biogenesis Vestibulocochlear Nerve Development Positive Regulation Of Synaptic Transmission, Dopaminergic Response To Stress Optic Nerve Morphogenesis Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Histone H3-K9 Trimethylation Positive Regulation Of Catecholamine Secretion Cellular Response To Stress Heterochromatin Assembly
Tagcloud ?		adrenal axis bcl1 beck besides carriers cc cholinergic depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing	acidification apparatus atpase atpases baf bafilomycin bapta barely bfa brefeldin chelator cma concanamycin cos7 egfp grp78 hek293 intravesicular ionophore isomerase organelles pdi perturbation perturbed relying secretion secretory transportation vacuolar
Tagcloud (Difference) ?		adrenal axis bcl1 beck besides carriers cc cholinergic depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing	acidification apparatus atpase atpases baf bafilomycin bapta barely bfa brefeldin chelator cma concanamycin cos7 egfp grp78 hek293 intravesicular ionophore isomerase organelles pdi perturbation perturbed relying secretion secretory transportation vacuolar
Tagcloud (Intersection) ?