CHRNA4 and VSNL1

Number of citations of the paper that reports this interaction (PubMedID 12202488)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CHRNA4	VSNL1
Description		cholinergic receptor nicotinic alpha 4 subunit	visinin like 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Dendrite Cation Channel Complex Presynaptic Membrane Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Synaptic Membrane Neurotransmitter Receptor Complex	Cytosol Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding ATP-dependent Chromatin Remodeler Activity	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Action Potential Response To Hypoxia DNA Repair Chromatin Remodeling Monoatomic Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Dopamine Secretion Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission	Regulation Of Signal Transduction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Succinylcholine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Carbamazepine Cisatracurium Atropine Thiopental Mecamylamine Scopolamine Isoflurane Estradiol Primidone Methylphenobarbital Ethanol Amantadine Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Pozanicline RPI-78M Epibatidine Cytisine Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 26440539 28972577 33144568) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking cessation ( 33082346) Smoking status (heavy vs never) ( 26423011)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Energy expenditure ( 30071075) Psychosis and Alzheimer's disease ( 22005930) Response to fenofibrate (total cholesterol levels) ( 27002377) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		10 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RAPSN RHOU SNCA UBQLN1 VSNL1 YWHAH	18 interacting genes: ACTB ATXN1 C1QTNF2 CDSN CHRNA4 COL10A1 DTX2 ENDOD1 FAM131C GFI1B HUNK LITAF SPRED1 SPRED2 SPRY3 SRL TEX13B TFF1
Entrez ID		1137	7447
HPRD ID		00333	02890
Ensembl ID		ENSG00000101204	ENSG00000163032
Uniprot IDs		B4DK78 P43681 Q4VAQ3 Q59FV0	P62760
PDB IDs		2LLY 5KXI 6CNJ 6CNK 6UR8 6USF 8SSZ 8ST0 8ST1 8ST2 8ST3 8ST4
Enriched GO Terms of Interacting Partners?		Synaptic Transmission, Cholinergic Synaptic Transmission Involved In Micturition Regulation Of Cell Communication Membrane Depolarization Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Excitatory Postsynaptic Potential Behavioral Response To Nicotine Acetylcholine Receptor Activity Neurotransmitter Receptor Complex Trans-synaptic Signaling Acetylcholine-gated Monoatomic Cation-selective Channel Activity Regulation Of Postsynaptic Membrane Potential Chemical Synaptic Transmission Synaptic Signaling Acetylcholine-gated Channel Complex Cation Channel Complex Regulation Of Dopamine Metabolic Process Regulation Of Dopamine Secretion Regulation Of Membrane Potential Adult Behavior Regulation Of Transport Synapse Postsynaptic Specialization Membrane Ligand-gated Monoatomic Ion Channel Activity Locomotory Behavior Regulation Of Biological Quality Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Regulation Of Secretion By Cell Protein-macromolecule Adaptor Activity Regulation Of Catecholamine Secretion Response To Cocaine Cell-cell Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Protein Domain Specific Binding Response To Nicotine Regulation Of Secretion Signaling Postsynaptic Signal Transduction Cell Communication Smooth Muscle Contraction Regulation Of Dendrite Morphogenesis Neural Nucleus Development Positive Regulation Of Secretion By Cell Lateral Geniculate Nucleus Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Negative Regulation Of Lens Fiber Cell Differentiation Stem Cell Factor Receptor Binding Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nuclear Matrix Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Negative Regulation Of Cornification Collagen Type X Trimer Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Projection Arborization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Epithelial Cell Differentiation
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