CHRNA4

Description		cholinergic receptor nicotinic alpha 4 subunit
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GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Dendrite Cation Channel Complex Presynaptic Membrane Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Synaptic Membrane Neurotransmitter Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Action Potential Response To Hypoxia DNA Repair Chromatin Remodeling Monoatomic Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Dopamine Secretion Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Succinylcholine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Carbamazepine Cisatracurium Atropine Thiopental Mecamylamine Scopolamine Isoflurane Estradiol Primidone Methylphenobarbital Ethanol Amantadine Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Pozanicline RPI-78M Epibatidine Cytisine Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 26440539 28972577 33144568) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking cessation ( 33082346) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		10 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RAPSN RHOU SNCA UBQLN1 VSNL1 YWHAH
Entrez ID		1137
HPRD ID		00333
Ensembl ID		ENSG00000101204
Uniprot IDs		B4DK78 P43681 Q4VAQ3 Q59FV0
PDB IDs		2LLY 5KXI 6CNJ 6CNK 6UR8 6USF 8SSZ 8ST0 8ST1 8ST2 8ST3 8ST4
Enriched GO Terms of Interacting Partners?		Synaptic Transmission, Cholinergic Synaptic Transmission Involved In Micturition Regulation Of Cell Communication Membrane Depolarization Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Excitatory Postsynaptic Potential Behavioral Response To Nicotine Acetylcholine Receptor Activity Neurotransmitter Receptor Complex Trans-synaptic Signaling Acetylcholine-gated Monoatomic Cation-selective Channel Activity Regulation Of Postsynaptic Membrane Potential Chemical Synaptic Transmission Synaptic Signaling Acetylcholine-gated Channel Complex Cation Channel Complex Regulation Of Dopamine Metabolic Process Regulation Of Dopamine Secretion Regulation Of Membrane Potential Adult Behavior Regulation Of Transport Synapse Postsynaptic Specialization Membrane Ligand-gated Monoatomic Ion Channel Activity Locomotory Behavior Regulation Of Biological Quality Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Regulation Of Secretion By Cell Protein-macromolecule Adaptor Activity Regulation Of Catecholamine Secretion Response To Cocaine Cell-cell Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Protein Domain Specific Binding Response To Nicotine Regulation Of Secretion Signaling Postsynaptic Signal Transduction Cell Communication Smooth Muscle Contraction Regulation Of Dendrite Morphogenesis Neural Nucleus Development Positive Regulation Of Secretion By Cell Lateral Geniculate Nucleus Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity
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