FMNL1 and PFN2

Number of citations of the paper that reports this interaction (PubMedID 10958683)
57

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FMNL1	PFN2
Description		formin like 1	profilin 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Bleb Cell Projection Phagocytic Vesicle Extracellular Exosome	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding GTPase Activating Protein Binding Actin Filament Binding	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actin Filament Severing	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways		RHO GTPases Activate Formins RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle	Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			Triglyme Pentaglyme
Diseases
GWAS		Asthma ( 31619474 31959851) Craniofacial microsomia ( 26853712) Hypothyroidism ( 30367059) Male-pattern baldness ( 28196072) Thyroid stimulating hormone levels ( 30367059)	Fish- and plant-related diet ( 32066663)
Interacting Genes		11 interacting genes: APP GAS7 HMG20A PFN1 PFN2 PRPF40A RAC1 SRPK2 TCERG1 TRIM54 XRCC6	34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		752	5217
HPRD ID		06876	01451
Ensembl ID		ENSG00000184922	ENSG00000070087
Uniprot IDs		O95466	P35080
PDB IDs		4YDH	1D1J
Enriched GO Terms of Interacting Partners?		Regulation Of Ruffle Assembly Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Polymerization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Ruffle Assembly Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Polymerization Modification Of Postsynaptic Structure Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Modification Of Synaptic Structure Actin Monomer Binding Hyperosmotic Response Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytoskeleton Organization Regulation Of Neuron Differentiation Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Presynapse Regulation Of Phosphorus Metabolic Process Postsynapse Dendrite Development Positive Regulation Of Protein Phosphorylation Regulation Of Cell Projection Assembly Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuronal Synaptic Plasticity Cell Projection Morphogenesis Innate Immune Response Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Synapse Organization Positive Regulation Of Phosphorylation Regulation Of Protein Modification Process Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cellular Component Organization Regulation Of Nitric Oxide Metabolic Process Response To External Biotic Stimulus	Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding
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