FMNL1 and PFN2

Number of citations of the paper that reports this interaction (PMID 10958683)
22

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FMNL1	PFN2
Gene Name		formin-like 1	profilin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Cortex Membrane Bleb Phagocytic Vesicle Extracellular Vesicular Exosome	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Binding Profilin Binding GTPase Activating Protein Binding Rac GTPase Binding Actin Filament Binding	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Substrate-dependent Cell Migration Regulation Of Cell Shape Cortical Actin Cytoskeleton Organization Actin Filament Severing	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways			Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP GAS7 HMG20A PFN1 PFN2 PRPF40A RAC1 TCERG1 XRCC6	31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		752	5217
HPRD ID		06876	01451
Ensembl ID		ENSG00000184922	ENSG00000070087
Uniprot IDs		O95466	G5E9Q6 P35080
PDB IDs			1D1J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Regulation Of Ruffle Assembly Organelle Organization Cytoskeleton Organization Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Hyperosmotic Response Platelet Activation Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cytoskeleton Organization Nervous System Development Positive Regulation Of ATPase Activity Actin Filament-based Process Regulation Of ATPase Activity Actin Filament Polymerization Generation Of Neurons Neurogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Development Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription From RNA Polymerase II Promoter Platelet Degranulation Regulation Of Cellular Component Organization Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament-based Process Positive Regulation Of Organelle Organization Blood Coagulation Actin Polymerization Or Depolymerization Hemostasis Negative Regulation Of Protein Polymerization Response To Osmotic Stress Regulation Of Cell Morphogenesis Regulation Of Metabolic Process Regulation Of Cell Projection Organization Protein Polymerization Regulation Of Cytoskeleton Organization Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Synaptic Growth At Neuromuscular Junction Regulation Of Body Fluid Levels	Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly
Tagcloud ?		actin biochemical cathepsin cation content depletion dispersal distinctly dramatic enlargement formin formins fragmentation golgi ill importantly integrity isoform lysosomal lysosomes maintain maintenance mannose member missorting nucleators phosphate relate	actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?		actin biochemical cathepsin cation content depletion dispersal distinctly dramatic enlargement formin formins fragmentation golgi ill importantly integrity isoform lysosomal lysosomes maintain maintenance mannose member missorting nucleators phosphate relate	actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?