FMNL1 and TCERG1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		FMNL1	TCERG1
Description		formin like 1	transcription elongation regulator 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Bleb Cell Projection Phagocytic Vesicle Extracellular Exosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding GTPase Activating Protein Binding Actin Filament Binding	Transcription Elongation Factor Activity Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actin Filament Severing	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RHO GTPases Activate Formins RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Craniofacial microsomia ( 26853712) Hypothyroidism ( 30367059) Male-pattern baldness ( 28196072) Thyroid stimulating hormone levels ( 30367059)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		11 interacting genes: APP GAS7 HMG20A PFN1 PFN2 PRPF40A RAC1 SRPK2 TCERG1 TRIM54 XRCC6	56 interacting genes: ABI1 AURKA BARD1 CEBPA CHAF1A CHD3 CYFIP1 CYFIP2 DIAPH1 DIAPH2 DNAJB9 ESR1 EVL FANCA FANCC FMNL1 GRB2 HNRNPH1 HNRNPK HNRNPM HNRNPU HSPA1A HSPA5 HSPA8 HTT JUNB LUC7L NONO NPM1 NUDT21 PCBP1 PIAS4 POLR2A PSPC1 RNF10 RUNX1 SETDB1 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SRSF1 SUMO2 TPM4 U2AF2 UBE2I WAS WASF2 WBP4 WIPF2 WWOX
Entrez ID		752	10915
HPRD ID		06876	10393
Ensembl ID		ENSG00000184922	ENSG00000113649
Uniprot IDs		O95466	A0A7P0T8N8 O14776
PDB IDs		4YDH	2DK7 2DOD 2DOE 2DOF 2E71 2KIQ 2KIS 2MW9 2MWA 2MWB 2MWD 2MWE 2MWF 2N4R 2N4S 2N4T 2N4U 2N4V 2N4W 2NNT 3HFH 3Q1I 4FQG 7ABF 7ABG 8Q7N 8QO9
Enriched GO Terms of Interacting Partners?		Regulation Of Ruffle Assembly Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Polymerization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Ruffle Assembly Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Polymerization Modification Of Postsynaptic Structure Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Modification Of Synaptic Structure Actin Monomer Binding Hyperosmotic Response Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytoskeleton Organization Regulation Of Neuron Differentiation Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Presynapse Regulation Of Phosphorus Metabolic Process Postsynapse Dendrite Development Positive Regulation Of Protein Phosphorylation Regulation Of Cell Projection Assembly Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuronal Synaptic Plasticity Cell Projection Morphogenesis Innate Immune Response Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Synapse Organization Positive Regulation Of Phosphorylation Regulation Of Protein Modification Process Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cellular Component Organization Regulation Of Nitric Oxide Metabolic Process Response To External Biotic Stimulus	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process RNA Binding Catalytic Step 2 Spliceosome Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Nuclear Speck Nucleoplasm U2-type Prespliceosome Assembly Nucleus Nucleic Acid Binding U2 SnRNP RNA Metabolic Process Nucleobase-containing Compound Metabolic Process U2-type Spliceosomal Complex U2-type Precatalytic Spliceosome RNA Processing Protein-containing Complex Assembly Protein-containing Complex Organization Protein-RNA Complex Assembly Paraspeckles Cellular Component Assembly MRNA Splice Site Recognition MRNA 3'-splice Site Recognition U2-type Prespliceosome Regulation Of RNA Splicing SCAR Complex Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Matrix Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Actin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Actin Polymerization Or Depolymerization Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex MRNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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