FMNL1 and HMG20A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FMNL1	HMG20A
Description		formin like 1	high mobility group 20A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Bleb Cell Projection Phagocytic Vesicle Extracellular Exosome	Nucleus
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding GTPase Activating Protein Binding Actin Filament Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actin Filament Severing	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of Protein Sumoylation Negative Regulation Of Neuron Differentiation
Pathways		RHO GTPases Activate Formins RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Craniofacial microsomia ( 26853712) Hypothyroidism ( 30367059) Male-pattern baldness ( 28196072) Thyroid stimulating hormone levels ( 30367059)	Fasting glucose ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Glycated hemoglobin levels ( 34059833) Hand grip strength ( 29691431) Hemoglobin A1c levels ( 29403010) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 21490949 21874001 22693455 22885922 24509480 28869590 30054458 30297969 30718926 32499647)
Interacting Genes		11 interacting genes: APP GAS7 HMG20A PFN1 PFN2 PRPF40A RAC1 SRPK2 TCERG1 TRIM54 XRCC6	59 interacting genes: ADD1 AGR2 BACH2 BRAP C9orf72 CCDC136 CCNK CEP95 CFAP53 CREBBP DCTN4 DDIT4L DGCR6L DTNB DYRK1A FBXO7 FMNL1 FOXD4L1 FXR1 GADD45GIP1 GPSM1 GTF2A1L HPCAL1 KIFC3 KPNA2 KRT1 LMO1 LNX1 LURAP1 MAGOHB NTAQ1 NUTF2 OLIG3 PIAS2 PICK1 PSMB1 PSORS1C2 PSTPIP1 PTH2R QARS1 RAD54L2 RBM11 RBM7 RIN1 RPP30 RPRD1B RSPH9 RUSC1 SCNM1 SMAD4 SMYD1 SUOX SYTL4 TBC1D22B TCP11L1 TESC TRAF4 TRAPPC5 USHBP1
Entrez ID		752	10363
HPRD ID		06876	16116
Ensembl ID		ENSG00000184922	ENSG00000140382
Uniprot IDs		O95466	B4DMG1 Q9NP66
PDB IDs		4YDH
Enriched GO Terms of Interacting Partners?		Regulation Of Ruffle Assembly Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Polymerization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Ruffle Assembly Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Polymerization Modification Of Postsynaptic Structure Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Modification Of Synaptic Structure Actin Monomer Binding Hyperosmotic Response Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytoskeleton Organization Regulation Of Neuron Differentiation Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Presynapse Regulation Of Phosphorus Metabolic Process Postsynapse Dendrite Development Positive Regulation Of Protein Phosphorylation Regulation Of Cell Projection Assembly Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuronal Synaptic Plasticity Cell Projection Morphogenesis Innate Immune Response Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Synapse Organization Positive Regulation Of Phosphorylation Regulation Of Protein Modification Process Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cellular Component Organization Regulation Of Nitric Oxide Metabolic Process Response To External Biotic Stimulus	Protein Binding
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