FMNL1 and GAS7

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		FMNL1	GAS7
Description		formin like 1	growth arrest specific 7
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Bleb Cell Projection Phagocytic Vesicle Extracellular Exosome	Cytoplasm Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding GTPase Activating Protein Binding Actin Filament Binding	Protein Binding Identical Protein Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actin Filament Severing	Nervous System Development Cell Differentiation Clathrin Coat Assembly Neuron Projection Morphogenesis Clathrin-dependent Endocytosis
Pathways		RHO GTPases Activate Formins RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Craniofacial microsomia ( 26853712) Hypothyroidism ( 30367059) Male-pattern baldness ( 28196072) Thyroid stimulating hormone levels ( 30367059)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Declining hemoglobin trajectory in blood donors ( 33491795) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Gut microbiota relative abundance (Prevotella) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 29617998 30054594 29235454 31798171 28073927 31959993 25173106 24002674 22570627) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		11 interacting genes: APP GAS7 HMG20A PFN1 PFN2 PRPF40A RAC1 SRPK2 TCERG1 TRIM54 XRCC6	28 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MECOM MIR196B MYBPC2 NCKAP1 NCKAP1L NTAQ1 PACSIN1 PKNOX1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A
Entrez ID		752	8522
HPRD ID		06876	16011
Ensembl ID		ENSG00000184922	ENSG00000007237
Uniprot IDs		O95466	O60861
PDB IDs		4YDH	2LX7 2YSH
Enriched GO Terms of Interacting Partners?		Regulation Of Ruffle Assembly Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Polymerization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Ruffle Assembly Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Polymerization Modification Of Postsynaptic Structure Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Modification Of Synaptic Structure Actin Monomer Binding Hyperosmotic Response Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytoskeleton Organization Regulation Of Neuron Differentiation Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Presynapse Regulation Of Phosphorus Metabolic Process Postsynapse Dendrite Development Positive Regulation Of Protein Phosphorylation Regulation Of Cell Projection Assembly Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuronal Synaptic Plasticity Cell Projection Morphogenesis Innate Immune Response Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Synapse Organization Positive Regulation Of Phosphorylation Regulation Of Protein Modification Process Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cellular Component Organization Regulation Of Nitric Oxide Metabolic Process Response To External Biotic Stimulus	SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Lamellipodium Organization Positive Regulation Of Actin Nucleation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytosol Cortical Actin Cytoskeleton Organization Actin Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Lamellipodium Assembly Regulation Of Lamellipodium Assembly MRNA 3'-splice Site Recognition Actin Filament-based Process Regulation Of Actin Filament Polymerization Lamellipodium Morphogenesis Cortical Cytoskeleton Organization Regulation Of Actin Filament Organization Small GTPase Binding Regulation Of Actin Polymerization Or Depolymerization Cell Projection Morphogenesis Regulation Of Actin Filament Length Regulation Of Lamellipodium Organization Cell Projection Dendrite Extension Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Myeloid Cell Development Regulation Of Cytoskeleton Organization Hemopoiesis RNA 7-methylguanosine Cap Binding Regulation Of Actin Cytoskeleton Organization Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Cell Morphogenesis Cell Projection Assembly MRNA Splicing, Via Spliceosome MRNA Cis Splicing, Via Spliceosome Actin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization RNA Splicing, Via Transesterification Reactions Regulation Of Organelle Organization Poly(U) RNA Binding
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