FMNL1 and XRCC6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		FMNL1	XRCC6
Gene Name		formin-like 1	X-ray repair complementing defective repair in Chinese hamster cells 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Cortex Membrane Bleb Phagocytic Vesicle Extracellular Vesicular Exosome	Nuclear Telomere Cap Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex
	Molecular Function	Molecular_function Protein Binding Profilin Binding GTPase Activating Protein Binding Rac GTPase Binding Actin Filament Binding	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Substrate-dependent Cell Migration Regulation Of Cell Shape Cortical Actin Cytoskeleton Organization Actin Filament Severing	Telomere Maintenance DNA Ligation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Transcription, DNA-templated Brain Development Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding V(D)J Recombination Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neurogenesis Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency
Pathways			Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP GAS7 HMG20A PFN1 PFN2 PRPF40A RAC1 TCERG1 XRCC6	126 interactors: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 FMNL1 GAL3ST4 GSE1 GZMA GZMB H2AFX HERPUD1 HMGA2 HN1L HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11A MSX2 NAA15 NCF4 NCL NCOA6 NHP2L1 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SEP15 SERPINA2 SERPINB9 SGOL1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SPARC TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TP53 VAV1 VBP1 WBP4 WRN XRCC5 XRCC6BP1 YWHAZ ZNF512B
Entrez ID		752	2547
HPRD ID		06876	01071
Ensembl ID		ENSG00000184922	ENSG00000196419
Uniprot IDs		O95466	B1AHC8 B1AHC9 P12956
PDB IDs			1JEQ 1JEY 1JJR 3RZX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Regulation Of Ruffle Assembly Organelle Organization Cytoskeleton Organization Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Hyperosmotic Response Platelet Activation Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cytoskeleton Organization Nervous System Development Positive Regulation Of ATPase Activity Actin Filament-based Process Regulation Of ATPase Activity Actin Filament Polymerization Generation Of Neurons Neurogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Development Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription From RNA Polymerase II Promoter Platelet Degranulation Regulation Of Cellular Component Organization Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament-based Process Positive Regulation Of Organelle Organization Blood Coagulation Actin Polymerization Or Depolymerization Hemostasis Negative Regulation Of Protein Polymerization Response To Osmotic Stress Regulation Of Cell Morphogenesis Regulation Of Metabolic Process Regulation Of Cell Projection Organization Protein Polymerization Regulation Of Cytoskeleton Organization Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Synaptic Growth At Neuromuscular Junction Regulation Of Body Fluid Levels	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Chromosome Organization Regulation Of Cell Death Regulation Of Cellular Component Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Cell Cycle Process Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Organic Substance Cellular Response To Stress Organelle Organization Positive Regulation Of Gene Expression Gene Expression DNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Telomere Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Mitotic Cell Cycle Embryo Development Negative Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Biosynthetic Process Regulation Of Catalytic Activity Cellular Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		actin biochemical cathepsin cation content depletion dispersal distinctly dramatic enlargement formin formins fragmentation golgi ill importantly integrity isoform lysosomal lysosomes maintain maintenance mannose member missorting nucleators phosphate relate	brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5
Tagcloud (Difference) ?		actin biochemical cathepsin cation content depletion dispersal distinctly dramatic enlargement formin formins fragmentation golgi ill importantly integrity isoform lysosomal lysosomes maintain maintenance mannose member missorting nucleators phosphate relate	brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5
Tagcloud (Intersection) ?