WFS1 and MAPK6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		WFS1	MAPK6
Gene Name		Wolfram syndrome 1 (wolframin)	mitogen-activated protein kinase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite	Nucleus Cytoplasm
	Molecular Function	Transporter Activity Calmodulin Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Calcium-dependent Protein Binding ATPase Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity
	Biological Process	Kidney Development Renal Water Homeostasis ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Olfactory Behavior Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Growth Protein Stabilization Neurological System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Polyubiquitinated Misfolded Protein Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900)
Protein-Protein Interactions		4 interactors: EIF6 MAPK6 SMURF1 TERF1	167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		7466	5597
HPRD ID		05864	04213
Ensembl ID		ENSG00000109501	ENSG00000069956
Uniprot IDs		O76024	Q16659
PDB IDs			2I6L
Enriched GO Terms of Interacting Partners?		Nuclear Export Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Nucleocytoplasmic Transport Nuclear Transport Mature Ribosome Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Ubiquitin-dependent SMAD Protein Catabolic Process Ribosomal Subunit Export From Nucleus Replicative Cell Aging Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Protein Localization To Cell Surface Receptor Catabolic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Ribosomal Large Subunit Biogenesis Ectoderm Development Ribosome Assembly Regulation Of Microtubule Polymerization Cytoplasmic Transport Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Protein Export From Nucleus Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Negative Regulation Of BMP Signaling Pathway Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cellular Protein Catabolic Process	Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated
Tagcloud ?		activating active atf6 atf6alpha atf6alphap50 atf6beta atf6betap60 basic consists endoplasmic er essential induce ins insulinoma islets isoforms knock maintain microarray pancreatic relates reticulum rodent stress susceptibility undergoing unfolded upr	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Difference) ?		activating active atf6 atf6alpha atf6alphap50 atf6beta atf6betap60 basic consists endoplasmic er essential induce ins insulinoma islets isoforms knock maintain microarray pancreatic relates reticulum rodent stress susceptibility undergoing unfolded upr	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Intersection) ?