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WFS1 and MAPK6
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
WFS1
MAPK6
Description
wolframin ER transmembrane glycoprotein
mitogen-activated protein kinase 6
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Membrane
Transport Vesicle
Secretory Granule
Dendrite
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Septin Cytoskeleton
Protein-containing Complex
Molecular Function
Protein Binding
Calmodulin Binding
Ubiquitin Protein Ligase Binding
Calcium-dependent Protein Binding
ATPase Binding
Proteasome Binding
DNA-binding Transcription Factor Binding
Protein Carrier Chaperone
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Kidney Development
Renal Water Homeostasis
ER Overload Response
Visual Perception
Sensory Perception Of Sound
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Translation
Endoplasmic Reticulum Unfolded Protein Response
Pancreas Development
Positive Regulation Of Protein Ubiquitination
Endoplasmic Reticulum Calcium Ion Homeostasis
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
ERAD Pathway
Olfactory Behavior
Glucose Homeostasis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Growth
Protein Stabilization
Nervous System Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Calcium Ion Transport
Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of ATF6-mediated Unfolded Protein Response
Positive Regulation Of ERAD Pathway
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
MAPK Cascade
Protein Phosphorylation
Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Dendritic Spine Development
Pathways
XBP1(S) activates chaperone genes
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
MAPK6/MAPK4 signaling
Drugs
Acetylsalicylic acid
Minocycline
Colforsin
Diseases
Wolfram syndrome (WFS); DIDMOAD syndrome
Type II diabetes mellitus
GWAS
Cisplatin-induced ototoxicity (
28039263
)
High density lipoprotein cholesterol levels (
32902719
)
Medication use (drugs used in diabetes) (
31015401
)
Mild age-related type 2 diabetes (
34737425
)
Type 2 diabetes (
20581827
32499647
31118516
30718926
30297969
30054458
29632382
29358691
28869590
24509480
22885922
19734900
)
Type 2 diabetes (adjusted for BMI) (
29632382
)
Frailty index (
34431594
)
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Interacting Genes
11 interacting genes:
AQP6
CD79A
DRD2
EIF6
F2RL1
FAM209A
LTB4R2
MAPK6
SMURF1
TERF1
TRARG1
167 interacting genes:
ACTG1
ACTR1B
AMPH
ANAPC5
ANK3
ANKRD2
APBA2
ARHGDIA
ARPC3
ATG9A
ATP5PF
BAG6
BARX1
BBS10
BTRC
CA1
CA12
CALR
CASP6
CCND3
CCT3
CDH13
CERS1
CFAP298
CFL1
CNTN1
CNTRL
COPS6
CSE1L
CYRIB
CYTH2
DBN1
DCTN2
DDOST
DDR1
DGKZ
DKC1
DNAJC28
DPPA4
DST
DYNC2I2
EDF1
EEF1A2
EIF1
EIF3C
EIF4A1
ELOF1
EMD
FBXL16
FOXO3
FXYD3
GALNT7
GATA1
GLRX3
GORASP1
GPX1
HACL1
HAUS2
HDAC11
HIP1
HNRNPA0
HNRNPD
HNRNPH3
HSP90AB1
HSP90B1
HSPD1
IDH3B
INS
ITGB3BP
ITSN1
JUNB
KDSR
KLC1
KNSTRN
LPXN
MAP3K12
MAP3K7
MAPKAPK5
MASP1
MBIP
MBOAT7
MCM3
MDK
METTL17
METTL2A
MGAT1
MIPEP
MOK
MON1A
MTG2
MYBL2
MYOZ3
MZB1
NAT9
NAXE
NDUFS6
NECTIN2
NELFB
NOL4
NRXN2
NUDT5
OSTF1
PDCD6IP
PDLIM1
PHACTR3
PHC2
PHGDH
PIH1D1
PLEKHM1
PLSCR1
PPBP
PPP1R7
PPP2R1A
PRKAB1
PRKAR1A
PRKCB
PRPF38A
PSAT1
PSIP1
PTPMT1
RAB2A
RAB31
RACK1
RANBP9
RAP1GAP
RARA
RBL1
RGS19
RPL10
RRP7A
SEPTIN3
SEPTIN5
SERPINA4
SHC1
SLC20A1
SLC41A3
SMAD6
SMS
SNAPC4
SNW1
SOCS3
SPG7
SPRR2D
SPTAN1
SRSF5
STX7
TDP2
THAP4
TPI1
TTK
TUBA1A
UBA52
UBE2L3
URB1
USP20
VPS26C
WDR26
WFS1
WWC1
XPO1
ZNF133
ZNF205
ZNF331
ZNF579
ZNF600
ZNF671
ZNF775
Entrez ID
7466
5597
HPRD ID
05864
04213
Ensembl ID
ENSG00000109501
ENSG00000069956
Uniprot IDs
A0A0S2Z4V6
O76024
Q16659
PDB IDs
6YKY
6YLC
6YLL
7AQB
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Insulin Secretion
Negative Regulation Of Establishment Of Protein Localization
Negative Regulation Of Peptide Secretion
Negative Regulation Of Hormone Secretion
Negative Regulation Of Protein Secretion
Negative Regulation Of Catecholamine Secretion
Negative Regulation Of Protein Transport
Renal System Process
Negative Regulation Of Secretion By Cell
G Protein-coupled Receptor Activity
G-protein Alpha-subunit Binding
Regulation Of Insulin Secretion
Negative Regulation Of Secretion
Regulation Of Catecholamine Secretion
Regulation Of Peptide Hormone Secretion
Nitrate Transmembrane Transporter Activity
Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
Positive Regulation Of Renin Secretion Into Blood Stream
Protein Localization To Plasma Membrane
Assembly Of Large Subunit Precursor Of Preribosome
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Positive Regulation Of Shelterin Complex Assembly
Engulfment Of Target By Autophagosome
Negative Regulation Of Protein Localization
Regulation Of Establishment Of Protein Localization
PH-gated Chloride Channel Activity
Nitrate Transmembrane Transport
G Protein-coupled Receptor Complex
Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production
Proteinase-activated Receptor Activity
Positive Regulation Of Eosinophil Degranulation
Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
Protein Localization To Cell Periphery
Septin Cytoskeleton
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Leukotriene B4 Receptor Activity
Regulation Of Hormone Secretion
Regulation Of Protein Secretion
Regulation Of Amine Transport
Alpha2-adrenergic Receptor Activity
Regulation Of Body Fluid Levels
Negative Regulation Of Activation Of Membrane Attack Complex
IgM B Cell Receptor Complex
Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go
Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Orbitofrontal Cortex Development
Negative Regulation Of Dopamine Receptor Signaling Pathway
Cytosol
Cytoplasm
Nucleus
Protein Binding
Extracellular Exosome
Ubiquitin Protein Ligase Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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