WFS1

Gene Name		Wolfram syndrome 1 (wolframin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite
	Molecular Function	Transporter Activity Calmodulin Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Kidney Development Renal Water Homeostasis ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Olfactory Behavior Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Growth Protein Stabilization Neurological System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Polyubiquitinated Misfolded Protein Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900)
Protein-protein Interactions		4 interactors: EIF6 MAPK6 SMURF1 TERF1
Entrez ID		7466
HPRD ID		05864
Ensembl ID		ENSG00000109501
Uniprot IDs		O76024
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Export Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Nucleocytoplasmic Transport Nuclear Transport Mature Ribosome Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Ubiquitin-dependent SMAD Protein Catabolic Process Ribosomal Subunit Export From Nucleus Replicative Cell Aging Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Protein Localization To Cell Surface Receptor Catabolic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Ribosomal Large Subunit Biogenesis Ectoderm Development Ribosome Assembly Regulation Of Microtubule Polymerization Cytoplasmic Transport Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Protein Export From Nucleus Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Negative Regulation Of BMP Signaling Pathway Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cellular Protein Catabolic Process
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