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WAS and RGS14
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
WAS
RGS14
Description
WASP actin nucleation promoting factor
regulator of G protein signaling 14
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Vesicle Membrane
Actin Cytoskeleton
Membrane
Site Of Double-strand Break
Phagocytic Vesicle
Extracellular Exosome
Spindle Pole
Nucleus
Cytoplasm
Centrosome
Spindle
Cytoskeleton
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Nuclear Body
PML Body
Dendrite
Cell Projection
Dendritic Spine
Synapse
Glutamatergic Synapse
Molecular Function
Actin Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
GTPase Regulator Activity
Small GTPase Binding
Identical Protein Binding
Phospholipase Binding
G-protein Alpha-subunit Binding
GTPase Activity
GDP-dissociation Inhibitor Activity
GTPase Activator Activity
Protein Binding
Microtubule Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
GTPase Regulator Activity
GTPase Activating Protein Binding
Biological Process
Regulation Of T Cell Antigen Processing And Presentation
Defense Response
Immune Response
Actin Filament Organization
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Actin Polymerization Or Depolymerization
Actin Polymerization Or Depolymerization
Epidermis Development
Regulation Of Lamellipodium Assembly
Endosomal Transport
Actin Filament Polymerization
Actin Filament-based Movement
Cdc42 Protein Signal Transduction
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Protein-containing Complex Assembly
Cellular Response To Type II Interferon
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Cell Motility
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Mitotic Cell Cycle
Nucleocytoplasmic Transport
Response To Oxidative Stress
Spindle Organization
Chromosome Segregation
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Learning
Long-term Memory
Regulation Of G Protein-coupled Receptor Signaling Pathway
Visual Learning
Negative Regulation Of Signal Transduction
Zygote Asymmetric Cell Division
Negative Regulation Of Synaptic Plasticity
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Neurogenesis
Modulation Of Chemical Synaptic Transmission
Cell Division
Long-term Synaptic Potentiation
Negative Regulation Of ERK1 And ERK2 Cascade
Pathways
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOJ GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
G alpha (i) signalling events
G alpha (i) signalling events
Drugs
(S)-wiskostatin
Diseases
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Platelet distribution width (
32888494
)
Activated partial thromboplastin time (
22703881
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Blood urea nitrogen levels (
31152163
)
Calcium levels (
24068962
)
Chronic kidney disease (
20383146
31152163
)
Circulating fibroblast growth factor 23 levels (
30217807
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (
29403010
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
28067908
)
Multiple sclerosis (
31604244
21833088
24076602
)
Nephrolithiasis (
22396660
)
Phosphorus levels (
29403010
)
Red blood cell count (
27863252
32888494
)
Renal function-related traits (eGRFcrea) (
22797727
)
Renal function-related traits (sCR) (
22797727
)
Serum parathyroid hormone levels (
27927781
)
Ulcerative colitis (
28067908
)
Urolithiasis (
30975718
)
Vitamin C levels (
33203707
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
61 interacting genes:
ABI3
ACTC1
ACTR2
APBB1
APPBP2
ARHGAP1
ARHGEF7
ARPC1B
ARPC2
ARPC3
BAIAP2L1
BTK
C5AR1
CDC42
CIB1
CREBBP
CRKL
CSNK2A1
CSNK2A2
DLG1
DVL2
ENAH
EVL
FCHSD2
FGR
FYB1
FYN
GRB2
HCK
HCLS1
ITK
ITSN2
LCK
LCP2
NCK1
NCK2
NCKIPSD
PIK3R1
PLCG1
PRPF40A
PSTPIP1
PTPN12
RAC1
RANBP2
RGS14
RHOJ
RPA1
RPA2
RPA3
SNX9
SORBS2
SRC
TCERG1
TEC
TNK2
TRIP10
UBASH3A
VASP
WBP4
WIPF1
WIPF2
16 interacting genes:
APP
GNA11
GNAI1
GNAI2
GNAI3
GNAO1
NFKB1
POT1
PRKACA
RAP1A
RAP2A
TINF2
TRAF2
VIPR2
WAS
XPO1
Entrez ID
7454
10636
HPRD ID
02314
03944
Ensembl ID
ENSG00000015285
ENSG00000169220
Uniprot IDs
A0A8V8TM35
P42768
O43566
PDB IDs
1CEE
1EJ5
1T84
2A3Z
2K42
2OT0
2JNU
2OM2
2XNS
3ONW
3QI2
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Actin Filament Polymerization
Actin Filament Organization
Regulation Of Actin Filament Polymerization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Positive Regulation Of Protein Polymerization
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Actin Filament Organization
Regulation Of Supramolecular Fiber Organization
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Actin Cytoskeleton Organization
Lamellipodium
Supramolecular Fiber Organization
Immune Response-activating Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Actin Filament-based Process
Regulation Of Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Supramolecular Fiber Organization
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Cytoskeleton Organization
Regulation Of Cellular Component Size
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Component Biogenesis
Cytosol
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Cytoplasm
Regulation Of Lamellipodium Organization
Positive Regulation Of Cellular Component Organization
Focal Adhesion
Positive Regulation Of Immune System Process
Regulation Of Cellular Component Organization
Positive Regulation Of Lamellipodium Organization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Immune Response
Cell Projection
SH3 Domain Binding
Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Organelle Organization
Regulation Of Immune Response
Peptidyl-tyrosine Phosphorylation
Intracellular Signal Transduction
Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
Guanyl Nucleotide Binding
G-protein Beta/gamma-subunit Complex Binding
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Heterotrimeric G-protein Complex
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
G Protein Activity
G Protein-coupled Receptor Binding
GTPase Activity
G Protein-coupled Receptor Signaling Pathway
GTP Binding
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
GDP Binding
Signal Transduction
G Protein-coupled Serotonin Receptor Signaling Pathway
Regulation Of Protein Transport
G Protein-coupled Serotonin Receptor Binding
Postsynaptic Modulation Of Chemical Synaptic Transmission
Modulation Of Chemical Synaptic Transmission
Regulation Of Biological Quality
Adenylate Cyclase Regulator Activity
Telomere Assembly
Regulation Of Transport
Regulation Of Establishment Of Protein Localization
Intracellular Signaling Cassette
Cellular Response To Oxygen-containing Compound
Regulation Of Secretion By Cell
Negative Regulation Of Secretion By Cell
Regulation Of Protein Localization
Shelterin Complex
Regulation Of Insulin Secretion
Regulation Of Secretion
Negative Regulation Of Secretion
Regulation Of Cellular Component Organization
Midbody
Nuclear Telomere Cap Complex
Synaptic Membrane
Regulation Of Peptide Hormone Secretion
Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Rap Protein Signal Transduction
Telomere Capping
Cell Body
Regulation Of Steroid Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Forskolin
Regulation Of Cell Junction Assembly
Nucleotide Binding
Regulation Of Hormone Secretion
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Tagcloud (Difference)
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Tagcloud (Intersection)
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