WAS and CIB1

Number of citations of the paper that reports this interaction (PMID 16582881)
14

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		WAS	CIB1
Gene Name		Wiskott-Aldrich syndrome	calcium and integrin binding 1 (calmyrin)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Plasma Membrane Membrane Apical Plasma Membrane Lamellipodium Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Actin Binding Small GTPase Regulator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Identical Protein Binding Phospholipase Binding	Calcium Ion Binding Protein Binding Ras GTPase Binding Protein Anchor Ion Channel Binding
	Biological Process	Protein Complex Assembly Defense Response Immune Response Blood Coagulation Actin Polymerization Or Depolymerization Epidermis Development Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatid Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Metalloenzyme Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways		TCR signaling Generation of second messenger molecules Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 ENAH EVL FCHSD2 FGR FYB FYN GAS7 GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RGS14 RHOJ SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2	21 interactors: AURKB CDK4 EXOSC10 FEZ1 IFI6 ITGA2B ITGB3 NBR1 NRIP1 PAX3 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 TERT UBR5 WAS ZDHHC17
Entrez ID		7454	10519
HPRD ID		02314	03800
Ensembl ID		ENSG00000015285
Uniprot IDs		P42768	H6WJF3 Q99828
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Locomotion Axon Guidance Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Filament Organization Innate Immune Response Chemotaxis Positive Regulation Of Actin Filament Polymerization Axonogenesis Neuron Projection Morphogenesis Immune Response Positive Regulation Of Protein Polymerization Enzyme Linked Receptor Protein Signaling Pathway Axon Development Actin Cytoskeleton Organization Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Cell Surface Receptor Signaling Pathway Endocytosis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Length Neuron Projection Development Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Signal Transduction T Cell Receptor Signaling Pathway Signaling	Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cell Death Homotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cell Death Cell Activation Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Neuron Differentiation Generation Of Neurons Developmental Process Single Organismal Cell-cell Adhesion Signaling Neurogenesis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Binding Nervous System Development Cell Development Neuron Development Regulation Of Cellular Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Component Organization Axon Guidance Organelle Organization Cell Death Movement Of Cell Or Subcellular Component Death Positive Regulation Of Cellular Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Multicellular Organismal Development Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Embryo Development Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cell Cycle
Tagcloud ?			accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Difference) ?			accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Intersection) ?