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WAS and RAC1
Number of citations of the paper that reports this interaction (PubMedID
8643625
)
35
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
WAS
RAC1
Description
WASP actin nucleation promoting factor
Rac family small GTPase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Vesicle Membrane
Actin Cytoskeleton
Membrane
Site Of Double-strand Break
Phagocytic Vesicle
Extracellular Exosome
Pericentriolar Material
Phagocytic Cup
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Trans-Golgi Network
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Cell Cortex
Membrane
Lamellipodium
Dendrite
Secretory Granule Membrane
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Ruffle Membrane
Cytoplasmic Ribonucleoprotein Granule
Melanosome
Presynaptic Membrane
Cell Projection
NADPH Oxidase Complex
Synapse
Postsynaptic Membrane
Recycling Endosome Membrane
Kinocilium
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Ficolin-1-rich Granule Membrane
Molecular Function
Actin Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
GTPase Regulator Activity
Small GTPase Binding
Identical Protein Binding
Phospholipase Binding
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
Enzyme Binding
Protein Kinase Binding
GTP-dependent Protein Binding
Thioesterase Binding
Protein-containing Complex Binding
Rho GDP-dissociation Inhibitor Binding
Biological Process
Regulation Of T Cell Antigen Processing And Presentation
Defense Response
Immune Response
Actin Filament Organization
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Actin Polymerization Or Depolymerization
Actin Polymerization Or Depolymerization
Epidermis Development
Regulation Of Lamellipodium Assembly
Endosomal Transport
Actin Filament Polymerization
Actin Filament-based Movement
Cdc42 Protein Signal Transduction
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Protein-containing Complex Assembly
Cellular Response To Type II Interferon
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Cell Motility
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Neuron Migration
Positive Regulation Of Protein Phosphorylation
Auditory Receptor Cell Morphogenesis
Sphingosine-1-phosphate Receptor Signaling Pathway
Epithelial Cell Morphogenesis
Endocytosis
Phagocytosis, Engulfment
Inflammatory Response
Hyperosmotic Response
Cytoskeleton Organization
Actin Filament Organization
Cell Adhesion
Cell-matrix Adhesion
Establishment Or Maintenance Of Cell Polarity
Enzyme-linked Receptor Protein Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Axon Guidance
Motor Neuron Axon Guidance
Regulation Of Cell Shape
Response To Wounding
Anatomical Structure Morphogenesis
Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Lamellipodium Assembly
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Endothelial Cell Migration
Regulation Of Fibroblast Migration
Negative Regulation Of Fibroblast Migration
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Neuron Maturation
Dendrite Development
Cell Migration
Rac Protein Signal Transduction
Cerebral Cortex Radially Oriented Cell Migration
Embryonic Olfactory Bulb Interneuron Precursor Migration
Cerebral Cortex GABAergic Interneuron Development
Regulation Of Cell Morphogenesis
Cell Projection Assembly
Lamellipodium Assembly
Actin Cytoskeleton Organization
Actin Filament Polymerization
Regulation Of Cell Migration
Positive Regulation Of Actin Filament Polymerization
Cortical Cytoskeleton Organization
Forebrain Development
Positive Regulation Of Microtubule Polymerization
Ruffle Organization
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-23 Production
Regulation Of Actin Cytoskeleton Organization
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Rho Protein Signal Transduction
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Superoxide Anion Generation
Erythrocyte Enucleation
Engulfment Of Apoptotic Cell
Cell-cell Junction Organization
Regulation Of Nitric Oxide Biosynthetic Process
Respiratory Burst
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Hepatocyte Growth Factor Receptor Signaling Pathway
Regulation Of Neuronal Synaptic Plasticity
Negative Regulation Of Receptor-mediated Endocytosis
Anatomical Structure Arrangement
Neuron Projection Morphogenesis
Dendrite Morphogenesis
Cell Motility
Homeostasis Of Number Of Cells Within A Tissue
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Localization Within Membrane
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Synaptic Transmission, GABAergic
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Respiratory Burst
Cell Chemotaxis
Positive Regulation Of Dendritic Spine Development
Regulation Of Cell Adhesion Involved In Heart Morphogenesis
Regulation Of ERK5 Cascade
Semaphorin-plexin Signaling Pathway
Dopaminergic Neuron Differentiation
Protein Localization To Plasma Membrane
Angiotensin-activated Signaling Pathway Involved In Heart Process
Positive Regulation Of Neutrophil Chemotaxis
Cochlea Morphogenesis
Ruffle Assembly
Regulation Of Postsynapse Assembly
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Ruffle Assembly
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Neutrophil Migration
Positive Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Interneuron Migration
Midbrain Dopaminergic Neuron Differentiation
Positive Regulation Of Ovarian Follicle Development
Regulation Of Neuron Migration
Pathways
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOJ GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Nef and signal transduction
NRAGE signals death through JNK
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
PCP/CE pathway
Sema4D mediated inhibition of cell attachment and migration
DCC mediated attractive signaling
DCC mediated attractive signaling
Activation of RAC1
Inactivation of CDC42 and RAC1
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate CIT
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
RHO GTPases Activate NADPH Oxidases
MAPK6/MAPK4 signaling
Neutrophil degranulation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
RAC1 GTPase cycle
NTRK2 activates RAC1
Activated NTRK2 signals through CDK5
Activation of RAC1 downstream of NMDARs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
WNT5:FZD7-mediated leishmania damping
Azathioprine ADME
Factors involved in megakaryocyte development and platelet production
Drugs
(S)-wiskostatin
Dextromethorphan
Azathioprine
Guanosine-5'-Diphosphate
Diseases
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Platelet distribution width (
32888494
)
Apolipoprotein A1 levels (
32203549
)
Basal cell carcinoma (
31174203
)
Body mass index (
26426971
)
Coronary artery disease (
29212778
)
Keratinocyte cancer (MTAG) (
31174203
)
LDL cholesterol levels (
32203549
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Red cell distribution width (
27863252
)
Interacting Genes
61 interacting genes:
ABI3
ACTC1
ACTR2
APBB1
APPBP2
ARHGAP1
ARHGEF7
ARPC1B
ARPC2
ARPC3
BAIAP2L1
BTK
C5AR1
CDC42
CIB1
CREBBP
CRKL
CSNK2A1
CSNK2A2
DLG1
DVL2
ENAH
EVL
FCHSD2
FGR
FYB1
FYN
GRB2
HCK
HCLS1
ITK
ITSN2
LCK
LCP2
NCK1
NCK2
NCKIPSD
PIK3R1
PLCG1
PRPF40A
PSTPIP1
PTPN12
RAC1
RANBP2
RGS14
RHOJ
RPA1
RPA2
RPA3
SNX9
SORBS2
SRC
TCERG1
TEC
TNK2
TRIP10
UBASH3A
VASP
WBP4
WIPF1
WIPF2
184 interacting genes:
ACTA1
ACTB
AGAP1
AGAP2
AKT1
ARAP1
ARAP2
ARFIP2
ARHGAP12
ARHGAP15
ARHGAP17
ARHGAP20
ARHGAP22
ARHGAP23
ARHGAP27
ARHGAP31
ARHGAP32
ARHGAP33
ARHGAP35
ARHGAP39
ARHGAP4
ARHGAP44
ARHGAP9
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF10
ARHGEF2
ARHGEF25
ARHGEF26
ARHGEF4
ARHGEF7
ARL2BP
BAG6
BAIAP2
BIRC2
BRINP1
CASP3
CASP7
CAV1
CDC23
CDC42BPG
CDC42SE1
CDC42SE2
CEBPA
CFAP36
CHN1
CHN2
CIT
COG5
CORO1C
CSN2
CYBA
CYBB
CYFIP1
DEF6
DIAPH1
DIAPH3
DMPK
DNMBP
DOCK1
DOCK2
DOCK3
DOCK7
DOCK8
DVL1
DVL2
EIF2AK2
ENAH
FAM13A
FAM13B
FGD5
FHOD1
FLNA
FMN2
FMNL1
GMIP
GRIA2
GRN
HACD3
HACE1
HDAC7
HPS4
ICMT
IFNGR1
IL1RAP
IQGAP1
IQGAP2
KPNA4
KPNA6
KRT40
KTN1
LATS1
LRP2
LTBP3
LTBP4
LZTS2
MAGI1
MAP3K10
MAP3K11
MAP3K4
MCF2
MCF2L
MCM3AP
MDFI
METAP2
MT-CO3
MTNR1A
MYD88
MYH9
NCF2
NCK1
NCKAP1
NEDD4
NME1
NOS2
NOXA1
NR2C2
OCRL
OPHN1
PAK1
PAK2
PAK3
PAK5
PARD6A
PARD6B
PARD6G
PIAS3
PIK3R1
PIP4K2A
PLD1
PLEKHG1
PLEKHG2
PLEKHG6
PLXNA1
PLXNB1
PPP2R2B
PREX1
PREX2
PRKCA
PRKCD
PRKCI
PRKN
PRMT6
PTK2
RACGAP1
RALBP1
RAP1GDS1
RASGRF1
RASGRF2
RCC2
RGL2
RPS6KB1
SET
SFPQ
SH3BP1
SH3RF1
SH3RF3
SNCA
SNX31
SRGAP1
SRGAP3
STAT1
STAT3
STAU1
SYDE2
SYNJ2
TBC1D3F
TIAM1
TLR2
TNFRSF12A
TRIM72
TRIO
TUBA4A
UBC
UNKL
USH1C
USP6
VAV1
VAV2
VAV3
VWF
WAS
WASF1
Entrez ID
7454
5879
HPRD ID
02314
03627
Ensembl ID
ENSG00000015285
ENSG00000136238
Uniprot IDs
A0A8V8TM35
P42768
A4D2P0
A4D2P1
P63000
PDB IDs
1CEE
1EJ5
1T84
2A3Z
2K42
2OT0
1E96
1FOE
1G4U
1HE1
1HH4
1I4D
1I4L
1I4T
1MH1
1RYF
1RYH
2FJU
2H7V
2NZ8
2P2L
2RMK
2VRW
2WKP
2WKQ
2WKR
2YIN
3B13
3BJI
3RYT
3SBD
3SBE
3SU8
3SUA
3TH5
4GZL
4GZM
4YON
5FI0
5HZH
5N6O
5O33
5QQD
5QQE
5QQF
5QQG
5QQH
5QQI
5QQJ
5QQK
5QQL
5QQM
5QQN
5QU9
6AGP
6BC1
6TGC
6X1G
7AJK
7DPA
7SJ4
7USD
7USE
8I5V
8I5W
8Q0N
8WEJ
8ZJ2
8ZJI
8ZJJ
8ZJK
8ZJL
8ZJM
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Actin Filament Polymerization
Actin Filament Organization
Regulation Of Actin Filament Polymerization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Positive Regulation Of Protein Polymerization
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Actin Filament Organization
Regulation Of Supramolecular Fiber Organization
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Actin Cytoskeleton Organization
Lamellipodium
Supramolecular Fiber Organization
Immune Response-activating Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Actin Filament-based Process
Regulation Of Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Supramolecular Fiber Organization
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Cytoskeleton Organization
Regulation Of Cellular Component Size
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Component Biogenesis
Cytosol
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Cytoplasm
Regulation Of Lamellipodium Organization
Positive Regulation Of Cellular Component Organization
Focal Adhesion
Positive Regulation Of Immune System Process
Regulation Of Cellular Component Organization
Positive Regulation Of Lamellipodium Organization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Immune Response
Cell Projection
SH3 Domain Binding
Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Organelle Organization
Regulation Of Immune Response
Peptidyl-tyrosine Phosphorylation
Intracellular Signal Transduction
Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
Regulation Of Small GTPase Mediated Signal Transduction
GTPase Activator Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Cytosol
Regulation Of Cell Communication
Regulation Of Signaling
Small GTPase Binding
Intracellular Signaling Cassette
Signal Transduction
Small GTPase-mediated Signal Transduction
Intracellular Signal Transduction
Guanyl-nucleotide Exchange Factor Activity
Regulation Of Cellular Component Organization
Cytoplasm
Regulation Of Cytoskeleton Organization
Regulation Of Actin Filament-based Process
Regulation Of Actin Cytoskeleton Organization
Plasma Membrane
Regulation Of Organelle Organization
Cell Cortex
Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament Organization
Regulation Of Cell Projection Organization
Glutamatergic Synapse
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Rho Protein Signal Transduction
Actin Filament Organization
Cell Projection Organization
Regulation Of Anatomical Structure Morphogenesis
Supramolecular Fiber Organization
Regulation Of Developmental Process
Postsynapse
Regulation Of Synapse Organization
SH3 Domain Binding
Regulation Of Cell Morphogenesis
Positive Regulation Of Signaling
Cell Projection
Positive Regulation Of Signal Transduction
Rho Protein Signal Transduction
Positive Regulation Of Cell Communication
Ruffle
Establishment Or Maintenance Of Cell Polarity
Positive Regulation Of Cellular Component Organization
Plasma Membrane Bounded Cell Projection Organization
Lamellipodium
Regulation Of Cell Shape
Cell Migration
Regulation Of Biological Quality
Lamellipodium Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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