WAS and BAIAP2L1

Number of citations of the paper that reports this interaction (PMID 22921828)
2

Data Source:
BioGRID (pull down)

		WAS	BAIAP2L1
Gene Name		Wiskott-Aldrich syndrome	BAI1-associated protein 2-like 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Small GTPase Regulator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Identical Protein Binding Phospholipase Binding	Actin Binding Proline-rich Region Binding
	Biological Process	Protein Complex Assembly Defense Response Immune Response Blood Coagulation Actin Polymerization Or Depolymerization Epidermis Development Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Plasma Membrane Organization Response To Bacterium Positive Regulation Of Actin Filament Polymerization Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		TCR signaling Generation of second messenger molecules Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Prostate cancer (gene x gene interaction) ( 22219177) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		53 interactors: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 ENAH EVL FCHSD2 FGR FYB FYN GAS7 GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RGS14 RHOJ SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2	6 interactors: FASLG KHDRBS1 MDM2 TP53 WAS YWHAG
Entrez ID		7454	55971
HPRD ID		02314	11270
Ensembl ID		ENSG00000015285	ENSG00000006453
Uniprot IDs		P42768	Q9UHR4
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0	2KXC 2LNH
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Locomotion Axon Guidance Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Filament Organization Innate Immune Response Chemotaxis Positive Regulation Of Actin Filament Polymerization Axonogenesis Neuron Projection Morphogenesis Immune Response Positive Regulation Of Protein Polymerization Enzyme Linked Receptor Protein Signaling Pathway Axon Development Actin Cytoskeleton Organization Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Cell Surface Receptor Signaling Pathway Endocytosis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Length Neuron Projection Development Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Signal Transduction T Cell Receptor Signaling Pathway Signaling	Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Mitotic Cell Cycle Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Mitotic Cell Cycle Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Necroptotic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Signal Transduction By P53 Class Mediator Programmed Necrotic Cell Death Regulation Of Cellular Localization Cell Cycle Process Necrotic Cell Death Cell Death Death Regulation Of Catalytic Activity Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To UV Positive Regulation Of Mitochondrion Organization Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Neuron Apoptotic Process Response To Antibiotic Positive Regulation Of Organelle Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response Regulation Of Signal Transduction Signal Transduction Negative Regulation Of Cell Cycle Mitotic G1 DNA Damage Checkpoint Negative Regulation Of Gene Expression Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Negative Regulation Of Biosynthetic Process Positive Regulation Of Neuron Death Cell Cycle
Tagcloud ?			amphiphysin bai1 bar bin cdkn2a ch5183284 constitutive debio deltabar dimerization discovered f3 fgfr fgfr3 fibroblast fusion harboring oncogenic rat rat2 rb1 rearrangements rvs screens signature suppressive transfectant transforming tumorigenic
Tagcloud (Difference) ?			amphiphysin bai1 bar bin cdkn2a ch5183284 constitutive debio deltabar dimerization discovered f3 fgfr fgfr3 fibroblast fusion harboring oncogenic rat rat2 rb1 rearrangements rvs screens signature suppressive transfectant transforming tumorigenic
Tagcloud (Intersection) ?