WAS and ARPC2

Number of citations of the paper that reports this interaction (PMID 11943145)
5

Data Source:
BioGRID (pull down)

		WAS	ARPC2
Gene Name		Wiskott-Aldrich syndrome	actin related protein 2/3 complex, subunit 2, 34kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Endosome Golgi Apparatus Cytosol Arp2/3 Protein Complex Plasma Membrane Focal Adhesion Actin Cytoskeleton Cell Leading Edge Neuron Projection Synapse Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Small GTPase Regulator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Identical Protein Binding Phospholipase Binding	Structural Constituent Of Cytoskeleton Protein Binding Kinesin Binding AP-1 Adaptor Complex Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Protein Complex Assembly Defense Response Immune Response Blood Coagulation Actin Polymerization Or Depolymerization Epidermis Development Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Movement Of Cell Or Subcellular Component Axon Guidance Positive Regulation Of Lamellipodium Assembly Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		TCR signaling Generation of second messenger molecules Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661)
Protein-Protein Interactions		53 interactors: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 ENAH EVL FCHSD2 FGR FYB FYN GAS7 GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RGS14 RHOJ SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2	6 interactors: ACTR3 ARPC1B ARPC4 AURKA CORO1B WAS
Entrez ID		7454	10109
HPRD ID		02314	10367
Ensembl ID		ENSG00000015285	ENSG00000163466
Uniprot IDs		P42768	O15144 Q53R19
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Locomotion Axon Guidance Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Filament Organization Innate Immune Response Chemotaxis Positive Regulation Of Actin Filament Polymerization Axonogenesis Neuron Projection Morphogenesis Immune Response Positive Regulation Of Protein Polymerization Enzyme Linked Receptor Protein Signaling Pathway Axon Development Actin Cytoskeleton Organization Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Cell Surface Receptor Signaling Pathway Endocytosis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Length Neuron Projection Development Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Signal Transduction T Cell Receptor Signaling Pathway Signaling	Regulation Of Cytoskeleton Organization Actin Filament Organization Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Nucleation Regulation Of Cellular Component Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Actin Filament Polymerization Regulation Of Protein Complex Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Projection Organization Immune Response-regulating Signaling Pathway Actin Polymerization Or Depolymerization Ephrin Receptor Signaling Pathway Negative Regulation Of Spindle Checkpoint Protein Polymerization Chemotaxis Neuron Projection Morphogenesis Positive Regulation Of Immune Response Endocytosis Protein Localization To Cell Leading Edge Spindle Assembly Involved In Female Meiosis I Cellular Component Assembly Negative Regulation Of Cytoskeleton Organization Meiotic Nuclear Division
Tagcloud ?			10q26 alleles carrying colitis constructed contribution dra dutch ecm1 flagged gas7 genotyped gwas hla il10 il23r loci make replicated replication s100z snps susceptibility tagging ten top trend uc ulcerative
Tagcloud (Difference) ?			10q26 alleles carrying colitis constructed contribution dra dutch ecm1 flagged gas7 genotyped gwas hla il10 il23r loci make replicated replication s100z snps susceptibility tagging ten top trend uc ulcerative
Tagcloud (Intersection) ?