WAS and DVL2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		WAS	DVL2
Description		WASP actin nucleation promoting factor	dishevelled segment polarity protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Membrane Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Lateral Plasma Membrane Nuclear Body Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding
	Biological Process	Regulation Of T Cell Antigen Processing And Presentation Defense Response Immune Response Actin Filament Organization Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Protein-containing Complex Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Neural Tube Closure Heart Looping Heart Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Segment Specification Heart Development Intracellular Protein Localization Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Regulation Of Actin Cytoskeleton Organization Segmentation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs		(S)-wiskostatin
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Platelet distribution width ( 32888494)	Metabolite levels ( 31628463)
Interacting Genes		61 interacting genes: ABI3 ACTC1 ACTR2 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CREBBP CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ RPA1 RPA2 RPA3 SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 UBASH3A VASP WBP4 WIPF1 WIPF2	105 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 AQP9 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 CUL1 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RAP1B RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UIMC1 USP5 USP9X VANGL1 VHL WAS WT1 WWP2 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581
Entrez ID		7454	1856
HPRD ID		02314	03690
Ensembl ID		ENSG00000015285	ENSG00000004975
Uniprot IDs		A0A8V8TM35 P42768	O14641
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0	2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3 6JCK 8WM9 8WMA 8WWR 8YR7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Actin Filament Polymerization Actin Filament Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Polymerization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Lamellipodium Supramolecular Fiber Organization Immune Response-activating Signaling Pathway Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Supramolecular Fiber Organization Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Size Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Cytosol Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Cytoplasm Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Immune System Process Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Cell Projection SH3 Domain Binding Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Organelle Organization Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization	Protein Binding Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Wnt Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cytosol Protein Modification By Small Protein Conjugation Protein Ubiquitination Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Protein Modification Process Nucleoplasm Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Protein Modification Process Cellular Component Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Cytoskeleton Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of RNA Metabolic Process Post-translational Protein Modification Autophagy
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