WAS and RANBP2

Number of citations of the paper that reports this interaction (PubMedID 26261240)
76

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		WAS	RANBP2
Description		WASP actin nucleation promoting factor	RAN binding protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Membrane Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome	Nucleus Nuclear Envelope Annulate Lamellae Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket SUMO Ligase Complex Cytoplasmic Periphery Of The Nuclear Pore Complex
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity GTPase Activator Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Activator Activity SUMO Transferase Activity Small GTPase Binding Protein-containing Complex Binding Metal Ion Binding SUMO Ligase Activity
	Biological Process	Regulation Of T Cell Antigen Processing And Presentation Defense Response Immune Response Actin Filament Organization Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Protein-containing Complex Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Response To Amphetamine Toll-like Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Gluconeogenesis Protein Folding NLS-bearing Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Protein Sumoylation Negative Regulation Of Innate Immune Response Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Export Centrosome Localization
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants
Drugs		(S)-wiskostatin
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Platelet distribution width ( 32888494)	Attention deficit hyperactivity disorder ( 29325848) Beard thickness ( 26926045) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045)
Interacting Genes		61 interacting genes: ABI3 ACTC1 ACTR2 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CREBBP CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ RPA1 RPA2 RPA3 SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 UBASH3A VASP WBP4 WIPF1 WIPF2	40 interacting genes: AKAP13 ARID4B CALM1 CDCA8 CEBPA CUL1 FHOD1 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MAP2K7 MDM2 MYBPC2 NR5A2 NUP62 NXF1 OPN1LW OPN1MW PDLIM3 PRKN PTEN RAN RANGAP1 RNF10 SENP1 SP100 SUMO1 SUMO2 TAF1 TNPO1 TOP2B UBE2I UBTD1 WAS XPO1 XPOT
Entrez ID		7454	5903
HPRD ID		02314	03111
Ensembl ID		ENSG00000015285	ENSG00000153201
Uniprot IDs		A0A8V8TM35 P42768	P49792
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0	1RRP 1XKE 1Z5S 2LAS 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW 5CLL 5CLQ 7MNJ 7MNK 7MNL 7MNM 7MNN 7MNO 7MNP 7MNQ 7MNR 7MNS 7MNT 7MNU 7MNV 7MNW 7MNX 7MNY 7MNZ 7R5J 7R5K 9B62
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Actin Filament Polymerization Actin Filament Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Polymerization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Lamellipodium Supramolecular Fiber Organization Immune Response-activating Signaling Pathway Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Supramolecular Fiber Organization Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Size Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Cytosol Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Cytoplasm Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Immune System Process Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Cell Projection SH3 Domain Binding Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Organelle Organization Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization	Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Nucleoplasm Protein Localization To Nucleus Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Transport Nuclear Import Signal Receptor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Organelle Nuclear Localization Sequence Binding Regulation Of Intracellular Protein Transport Establishment Of Localization In Cell Presynaptic Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intracellular Transport Positive Regulation Of RNA Biosynthetic Process Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Nucleus Import Into Nucleus Small GTPase Binding Nuclear Export Regulation Of Proteasomal Protein Catabolic Process Cellular Localization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription SUMO Transferase Activity Nuclear Membrane Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process NLS-bearing Protein Import Into Nucleus Regulation Of RNA Biosynthetic Process Intracellular Protein Transport Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Postsynaptic Cytosol Nuclear Envelope Regulation Of Protein Transport Establishment Of Protein Localization To Organelle Cytosol Cytoplasm RNA Transport RNA Export From Nucleus NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Macromolecule Biosynthetic Process
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