WAS and ITK

Number of citations of the paper that reports this interaction (PubMedID 8810341)
0

Data Source:
HPRD (in vivo, in vitro)

		WAS	ITK
Description		WASP actin nucleation promoting factor	IL2 inducible T cell kinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Membrane Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Regulation Of T Cell Antigen Processing And Presentation Defense Response Immune Response Actin Filament Organization Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Protein-containing Complex Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Positive Regulation Of Cytokine Production NK T Cell Differentiation Adaptive Immune Response Immune System Process Cellular Defense Response Signal Transduction Intracellular Signal Transduction T Cell Activation Gamma-delta T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs		(S)-wiskostatin	Staurosporine Pazopanib Fostamatinib Zanubrutinib
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Platelet distribution width ( 32888494)	Asthma ( 31959851 34103634) Daytime sleep phenotypes ( 27126917) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		61 interacting genes: ABI3 ACTC1 ACTR2 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CREBBP CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ RPA1 RPA2 RPA3 SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 UBASH3A VASP WBP4 WIPF1 WIPF2	34 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FGFR1 FYN GAB1 GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 MET PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS
Entrez ID		7454	3702
HPRD ID		02314	01746
Ensembl ID		ENSG00000015285	ENSG00000113263
Uniprot IDs		A0A8V8TM35 P42768	Q08881
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0	1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Actin Filament Polymerization Actin Filament Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Polymerization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Lamellipodium Supramolecular Fiber Organization Immune Response-activating Signaling Pathway Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Supramolecular Fiber Organization Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Size Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Cytosol Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Cytoplasm Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Immune System Process Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Cell Projection SH3 Domain Binding Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Organelle Organization Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization	Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Activation Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Signal Transduction Phospholipase Binding ERBB Signaling Pathway Regulation Of Apoptotic Process Immune System Process Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Protein Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Intracellular Signaling Cassette Leukocyte Activation Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Kinase Activity Regulation Of Immune Response Regulation Of MAPK Cascade Membrane Raft Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Binding
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