WAS and ARPC1B

Number of citations of the paper that reports this interaction (PMID 11943145)
5

Data Source:
HPRD (in vitro)

		WAS	ARPC1B
Gene Name		Wiskott-Aldrich syndrome	actin related protein 2/3 complex, subunit 1B, 41kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Small GTPase Regulator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Identical Protein Binding Phospholipase Binding	Structural Constituent Of Cytoskeleton Actin Filament Binding
	Biological Process	Protein Complex Assembly Defense Response Immune Response Blood Coagulation Actin Polymerization Or Depolymerization Epidermis Development Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Movement Of Cell Or Subcellular Component Arp2/3 Complex-mediated Actin Nucleation
Pathways		TCR signaling Generation of second messenger molecules Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 ENAH EVL FCHSD2 FGR FYB FYN GAS7 GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RGS14 RHOJ SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2	10 interactors: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA PAK1 SRPK2 WAS
Entrez ID		7454	10095
HPRD ID		02314	10366
Ensembl ID		ENSG00000015285	ENSG00000130429
Uniprot IDs		P42768	A4D275 O15143
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Locomotion Axon Guidance Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Filament Organization Innate Immune Response Chemotaxis Positive Regulation Of Actin Filament Polymerization Axonogenesis Neuron Projection Morphogenesis Immune Response Positive Regulation Of Protein Polymerization Enzyme Linked Receptor Protein Signaling Pathway Axon Development Actin Cytoskeleton Organization Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Cell Surface Receptor Signaling Pathway Endocytosis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Length Neuron Projection Development Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Signal Transduction T Cell Receptor Signaling Pathway Signaling	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Innate Immune Response Ephrin Receptor Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Projection Morphogenesis Endocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Positive Regulation Of Organelle Organization Immune Response Defense Response Positive Regulation Of Cytoskeleton Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Neuron Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Chemotaxis Arp2/3 Complex-mediated Actin Nucleation Neuron Differentiation Positive Regulation Of Immune Response Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Actin Filament-based Process Immune System Process Actin Nucleation Vesicle-mediated Transport Regulation Of Immune Response Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Positive Regulation Of Immune System Process Regulation Of Organelle Organization Generation Of Neurons Neurogenesis Cell Development Actin Cytoskeleton Organization Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Actin Filament-based Process Actin Filament Organization
Tagcloud ?			5q cd14 conjunction crtap cxcr4 damaged del exact exactly exert explain help ie impact lenalidomide microarray monocytes myelodysplastic necrosis niche profiling remission repressed restore stability stroma suppress tnf upregulated
Tagcloud (Difference) ?			5q cd14 conjunction crtap cxcr4 damaged del exact exactly exert explain help ie impact lenalidomide microarray monocytes myelodysplastic necrosis niche profiling remission repressed restore stability stroma suppress tnf upregulated
Tagcloud (Intersection) ?