RNF10 and PIWIL4

Number of citations: 61 (PubMedID 37723588)
Data Source: BioGRID (unspecified method)

		RNF10	PIWIL4
Name		ring finger protein 10	piwi like RNA-mediated gene silencing 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosolic Ribosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion P Granule PiP-body
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding RNA Binding RNA Endonuclease Activity PiRNA Binding
	Biological Process	Protein Monoubiquitination Negative Regulation Of Schwann Cell Proliferation Protein Ubiquitination Positive Regulation Of Myelination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Autoubiquitination Postsynapse To Nucleus Signaling Pathway Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Translation Spermatogenesis Epithelial Structure Maintenance Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Secondary PiRNA Processing Transposable Element Silencing By Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		None	PIWI-interacting RNA (piRNA) biogenesis Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
GWAS		Chronotype ( 26955885 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 27863252 ) Sensorimotor dexterity ( 31596458 ) Type 1 diabetes nephropathy ( 23028342 )	Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction) ( 18846501 ) Chromium levels ( 26025379 ) Colorectal cancer ( 29228715 ) Mood disorder and prion disease ( 25897833 ) Mood disorder in prion disease ( 25897833 ) Small cell lung carcinoma ( 28604730 )
Interacting Genes		380 interacting genes: AARS2 ACIN1 ACO1 ACO2 ACTN4 AFDN AFF2 AGGF1 AGO4 AKAP1 AKAP8 ALDH18A1 ANK3 ANKHD1 ANKRD17 ARHGEF1 ARHGEF2 ASCC3 ASH1L ATP1A1 ATXN1 BARD1 BAZ1B BAZ2B BCLAF1 BMS1 BTG3 CACTIN CALD1 CAND1 CAPRIN2 CARS1 CC2D1B CCAR1 CCAR2 CCDC90B CDC5L CDK11B CDK13 CEBPZ CELF1 CELF2 CFAP65 CGN CHD3 CMTR1 CMTR2 CNOT10 COL14A1 COL4A5 COPB1 COPG1 CPSF2 CRNKL1 CSDE1 CSE1L CTNNA1 CWC22 DDX1 DDX10 DDX23 DDX24 DDX27 DDX31 DDX42 DDX46 DDX54 DDX60 DDX60L DGCR8 DHX16 DHX32 DHX34 DHX36 DHX38 DHX9 DIS3 DMGDH DNAAF2 DNM1 DNTTIP2 DROSHA DSCR9 DSP DYNC2H1 DYSF DZIP1 EEF1A1 EFL1 EIF2AK3 EIF2AK4 EIF2B5 EIF3A EIF3C EIF3D EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 ELAC2 ELOA EPB41 EPB41L2 EPPK1 EPRS1 ERN1 ERN2 ESF1 FAM120A FAM120B FAM120C FASTKD5 FBRSL1 FLNA FTSJ3 FUBP3 GANAB GCFC2 GCN1 GEMIN4 GEMIN5 GFM1 GFM2 GIGYF2 GOLGA4 GOLGB1 GRB2 HDLBP HEATR1 HERC5 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HOOK1 HSP90B1 HSPA9 HTATSF1 HUWE1 IARS1 IFIH1 IMMT INTS1 INTS2 INTS4 INTS5 INTS8 IPO11 IPO13 IPO4 IPO5 IPO7 IPO8 KDM1A KDM5A KIF1C KMT2C KPNB1 KTN1 L1TD1 LARP1 LARP1B LARS1 LONP1 LRIF1 LRP1 LRPPRC LRRFIP1 MAP1B MAP4 MARS1 MATR3 MDM2 MKRN3 MOV10 MOV10L1 MPHOSPH10 MTCL1 MVP MYBBP1A MYH14 MYH9 MYO18A NAA15 NCBP1 NCL NKTR NLRP11 NOC2L NOC3L NOL8 NOP14 NOP2 NOVA1 NOVA2 NSF NSUN2 NUMA1 NVL OAS3 PAN3 PARP1 PARP4 PC PDCD11 PDCD6IP PDS5A PIWIL1 PIWIL2 PIWIL3 PIWIL4 PKN2 PMS1 PNPT1 POLR2A PPARGC1A PPIG PRKDC PRP4K PRPF40A PRPF40B PRPF6 PRRC2C PTBP1 QARS1 R3HCC1L RANBP17 RANBP2 RANBP6 RBM10 RBM12B RBM15B RBM19 RBM25 RBM27 RBM28 RBM4 RBM44 RBM5 RBM6 RIMS1 RNASEL RNF17 ROCK2 RPGR RPS10 RPS20 RPS3 RRBP1 RSPH1 RTN4 SAFB2 SART1 SART3 SCAF11 SCAF8 SEC23IP SEC63 SECISBP2 SECISBP2L SETD1B SETDB1 SETX SF3A1 SF3B2 SF3B3 SIDT1 SIDT2 SLC4A1AP SMG1 SMG6 SMG8 SNCA SND1 SNRNP200 SORBS1 SPTBN1 SPTBN5 SRBD1 SRP68 SRSF1 SRSF3 STK10 SUB1 SUGP2 SUPT16H SUPT6H SUPV3L1 SUZ12 SWT1 SYMPK SYNE2 TARBP1 TARBP2 TARS1 TARS3 TASOR TBL3 TCERG1 TCF20 TDRD1 TDRD12 TDRD5 TDRD6 TDRD7 TDRD9 TENT4A TEP1 TERF1 TFIP11 TGS1 THRAP3 TIPARP TLE1 TLR3 TLR7 TLR8 TNPO1 TNPO2 TNPO3 TNRC6B TNS1 TOP2A TPX2 TRIM55 TRIM63 TRMT44 TULP3 TUT7 U2SURP UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2H UBE2I UBE2J2 UBE2O UBE2U UBE2V1 UBE2W UBTD1 UBTF UNK UNKL UPF1 URB1 USO1 USP42 UTP14A UTP14C UTP20 VARS1 VCP VIL1 VIRMA WDR36 WDR43 WDR75 XAB2 XIRP1 XPO4 XPO6 XPO7 XPOT XRCC6 XRN1 XRN2 YBX1 ZBTB48 ZC3H11A ZC3H13 ZC3H4 ZCCHC2 ZFC3H1 ZFR ZFR2 ZNF106 ZNF346 ZNFX1	3 interacting genes: DICER1 RNF10 VHL
Entrez ID		9921	143689
HPRD ID		11496	11435
Ensembl ID		ENSG00000022840	ENSG00000134627
Uniprot IDs		A0A024RBP0 Q8N5U6	A0A140VKG8 Q7Z3Z4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		RNA Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process MRNA Processing Nucleus RNA Splicing Macromolecule Metabolic Process Nucleoplasm Nucleolus RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Helicase Activity Helicase Activity Protein-RNA Complex Assembly Post-transcriptional Regulation Of Gene Expression ATP Binding RNA Catabolic Process Double-stranded RNA Binding Catalytic Step 2 Spliceosome Regulation Of Gene Expression Nuclear Speck Regulation Of Macromolecule Biosynthetic Process ATP Hydrolysis Activity Cytoplasm Regulation Of RNA Splicing Regulation Of Translation Negative Regulation Of Gene Expression Regulation Of MRNA Processing RRNA Metabolic Process Spliceosomal Complex Nucleotide Binding MRNA Binding Regulation Of MRNA Stability Regulation Of RNA Stability RRNA Processing Regulation Of Macromolecule Metabolic Process Nucleocytoplasmic Transport Nuclear Transport PiRNA Processing Ribonucleoprotein Complex Regulation Of Primary Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome	Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Negative Regulation Of Cell Population Proliferation Regulation Of Gliogenesis Regulation Of Nervous System Process Negative Regulation Of Neurogenesis Regulatory RNA Binding Negative Regulation Of Nervous System Development Macromolecule Catabolic Process Peripheral Nervous System Myelin Formation Global Gene Silencing By MRNA Cleavage Positive Regulation Of Schwann Cell Differentiation Ribonuclease III Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Development Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of Cell Population Proliferation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Deoxyribonuclease I Activity Transcription Elongation Factor Activity Catabolic Process Regulation Of Neurogenesis RISC-loading Complex SiRNA Processing Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Pre-miRNA Binding RISC Complex Assembly Regulation Of Nervous System Development SiRNA Binding TRNA Decay Apoptotic DNA Fragmentation Proteasomal Protein Catabolic Process Pre-miRNA Processing Myelin Assembly Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Regulation Of System Process Modification-dependent Protein Catabolic Process Regulation Of Cellular Response To Hypoxia Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination