RNF10 and TLR8

Number of citations of the paper that reports this interaction (PubMedID 37723588)
61

Data Source:
BioGRID (unspecified method)

		RNF10	TLR8
Description		ring finger protein 10	toll like receptor 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosolic Ribosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Golgi Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Endolysosome Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Identical Protein Binding
	Biological Process	Protein Monoubiquitination Negative Regulation Of Schwann Cell Proliferation Protein Ubiquitination Positive Regulation Of Myelination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Autoubiquitination Postsynapse To Nucleus Signaling Pathway Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction Response To Virus Immunoglobulin Mediated Immune Response Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To Mechanical Stimulus Defense Response To Other Organism Endolysosomal Toll-like Receptor Signaling Pathway
Pathways			Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs			Imiquimod Resiquimod Selgantolimod Afimetoran
Diseases
GWAS		Chronotype ( 26955885) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sensorimotor dexterity ( 31596458) Type 1 diabetes nephropathy ( 23028342)	Celiac disease ( 20190752)
Interacting Genes		380 interacting genes: AARS2 ACIN1 ACO1 ACO2 ACTN4 AFDN AFF2 AGGF1 AGO4 AKAP1 AKAP8 ALDH18A1 ANK3 ANKHD1 ANKRD17 ARHGEF1 ARHGEF2 ASCC3 ASH1L ATP1A1 ATXN1 BARD1 BAZ1B BAZ2B BCLAF1 BMS1 BTG3 CACTIN CALD1 CAND1 CAPRIN2 CARS1 CC2D1B CCAR1 CCAR2 CCDC90B CDC5L CDK11B CDK13 CEBPZ CELF1 CELF2 CFAP65 CGN CHD3 CMTR1 CMTR2 CNOT10 COL14A1 COL4A5 COPB1 COPG1 CPSF2 CRNKL1 CSDE1 CSE1L CTNNA1 CWC22 DDX1 DDX10 DDX23 DDX24 DDX27 DDX31 DDX42 DDX46 DDX54 DDX60 DDX60L DGCR8 DHX16 DHX32 DHX34 DHX36 DHX38 DHX9 DIS3 DMGDH DNAAF2 DNM1 DNTTIP2 DROSHA DSCR9 DSP DYNC2H1 DYSF DZIP1 EEF1A1 EFL1 EIF2AK3 EIF2AK4 EIF2B5 EIF3A EIF3C EIF3D EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 ELAC2 ELOA EPB41 EPB41L2 EPPK1 EPRS1 ERN1 ERN2 ESF1 FAM120A FAM120B FAM120C FASTKD5 FBRSL1 FLNA FTSJ3 FUBP3 GANAB GCFC2 GCN1 GEMIN4 GEMIN5 GFM1 GFM2 GIGYF2 GOLGA4 GOLGB1 GRB2 HDLBP HEATR1 HERC5 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HOOK1 HSP90B1 HSPA9 HTATSF1 HUWE1 IARS1 IFIH1 IMMT INTS1 INTS2 INTS4 INTS5 INTS8 IPO11 IPO13 IPO4 IPO5 IPO7 IPO8 KDM1A KDM5A KIF1C KMT2C KPNB1 KTN1 L1TD1 LARP1 LARP1B LARS1 LONP1 LRIF1 LRP1 LRPPRC LRRFIP1 MAP1B MAP4 MARS1 MATR3 MDM2 MKRN3 MOV10 MOV10L1 MPHOSPH10 MTCL1 MVP MYBBP1A MYH14 MYH9 MYO18A NAA15 NCBP1 NCL NKTR NLRP11 NOC2L NOC3L NOL8 NOP14 NOP2 NOVA1 NOVA2 NSF NSUN2 NUMA1 NVL OAS3 PAN3 PARP1 PARP4 PC PDCD11 PDCD6IP PDS5A PIWIL1 PIWIL2 PIWIL3 PIWIL4 PKN2 PMS1 PNPT1 POLR2A PPARGC1A PPIG PRKDC PRP4K PRPF40A PRPF40B PRPF6 PRRC2C PTBP1 QARS1 R3HCC1L RANBP17 RANBP2 RANBP6 RBM10 RBM12B RBM15B RBM19 RBM25 RBM27 RBM28 RBM4 RBM44 RBM5 RBM6 RIMS1 RNASEL RNF17 ROCK2 RPGR RPS10 RPS20 RPS3 RRBP1 RSPH1 RTN4 SAFB2 SART1 SART3 SCAF11 SCAF8 SEC23IP SEC63 SECISBP2 SECISBP2L SETD1B SETDB1 SETX SF3A1 SF3B2 SF3B3 SIDT1 SIDT2 SLC4A1AP SMG1 SMG6 SMG8 SNCA SND1 SNRNP200 SORBS1 SPTBN1 SPTBN5 SRBD1 SRP68 SRSF1 SRSF3 STK10 SUB1 SUGP2 SUPT16H SUPT6H SUPV3L1 SUZ12 SWT1 SYMPK SYNE2 TARBP1 TARBP2 TARS1 TARS3 TASOR TBL3 TCERG1 TCF20 TDRD1 TDRD12 TDRD5 TDRD6 TDRD7 TDRD9 TENT4A TEP1 TERF1 TFIP11 TGS1 THRAP3 TIPARP TLE1 TLR3 TLR7 TLR8 TNPO1 TNPO2 TNPO3 TNRC6B TNS1 TOP2A TPX2 TRIM55 TRIM63 TRMT44 TULP3 TUT7 U2SURP UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2H UBE2I UBE2J2 UBE2O UBE2U UBE2V1 UBE2W UBTD1 UBTF UNK UNKL UPF1 URB1 USO1 USP42 UTP14A UTP14C UTP20 VARS1 VCP VIL1 VIRMA WDR36 WDR43 WDR75 XAB2 XIRP1 XPO4 XPO6 XPO7 XPOT XRCC6 XRN1 XRN2 YBX1 ZBTB48 ZC3H11A ZC3H13 ZC3H4 ZCCHC2 ZFC3H1 ZFR ZFR2 ZNF106 ZNF346 ZNFX1	3 interacting genes: BTK MYD88 RNF10
Entrez ID		9921	51311
HPRD ID		11496	02296
Ensembl ID		ENSG00000022840	ENSG00000101916
Uniprot IDs		A0A024RBP0 Q8N5U6	A0AA49X8T4 Q9NR97
PDB IDs			3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ 5Z14 5Z15 6KYA 6TY5 6V9U 6WML 6ZJZ 7CRF 7R52 7R53 7R54 7RC9 7YTX 8PFI 9MHW 9MHX 9MHY
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process MRNA Processing Nucleus RNA Splicing Macromolecule Metabolic Process Nucleoplasm Nucleolus RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Helicase Activity Helicase Activity Protein-RNA Complex Assembly Post-transcriptional Regulation Of Gene Expression ATP Binding RNA Catabolic Process Double-stranded RNA Binding Catalytic Step 2 Spliceosome Regulation Of Gene Expression Nuclear Speck Regulation Of Macromolecule Biosynthetic Process ATP Hydrolysis Activity Cytoplasm Regulation Of RNA Splicing Regulation Of Translation Negative Regulation Of Gene Expression Regulation Of MRNA Processing RRNA Metabolic Process Spliceosomal Complex Nucleotide Binding MRNA Binding Regulation Of MRNA Stability Regulation Of RNA Stability RRNA Processing Regulation Of Macromolecule Metabolic Process Nucleocytoplasmic Transport Nuclear Transport PiRNA Processing Ribonucleoprotein Complex Regulation Of Primary Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome	Response To Molecule Of Fungal Origin MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-17 Production Positive Regulation Of NLRP3 Inflammasome Complex Assembly Toll-like Receptor Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of DNA-binding Transcription Factor Activity Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Regulation Of Cytokine Production Involved In Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Lymphocyte Proliferation Regulation Of Interleukin-6 Production Positive Regulation Of Mononuclear Cell Proliferation B Cell Affinity Maturation Toll-like Receptor 5 Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Leukocyte Proliferation Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Toll-like Receptor 8 Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Synoviocyte Proliferation Cellular Response To Molecule Of Fungal Origin Activation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Histamine Secretion By Mast Cell Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Pwp2p-containing Subcomplex Of 90S Preribosome Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Proliferation
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