PLAA and KPNA4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLAA	KPNA4
Gene Name		phospholipase A2-activating protein	karyopherin alpha 4 (importin alpha 3)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Nucleoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phospholipase A2 Activator Activity	Protein Binding Protein Transporter Activity
	Biological Process	Phospholipid Metabolic Process Inflammatory Response Signal Transduction Positive Regulation Of Catalytic Activity	NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Response To Hydrogen Peroxide
Pathways			ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Schizophrenia ( 20185149)
Protein-Protein Interactions		6 interactors: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP	17 interactors: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 HNRNPC KPNB1 MAT2B NUP50 PLAA RAC1 RCC1 RECQL TGM2 TP53
Entrez ID		9373	3840
HPRD ID		04850	04275
Ensembl ID		ENSG00000137055	ENSG00000186432
Uniprot IDs		Q9Y263	O00629
PDB IDs		2K89 2K8A 2K8B 2K8C 3EBB
Enriched GO Terms of Interacting Partners?		Aggresome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Proteolysis Catabolic Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Protein Catabolic Process Cellular Response To Heat Intracellular Transport Proteolysis Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Hsp90 Deacetylation Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Programmed Cell Death Cellular Response To Topologically Incorrect Protein Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Response To Heat Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of MAPK Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Establishment Of Localization In Cell Protein Polyubiquitination Multicellular Organismal Lipid Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Complex Assembly Response To Temperature Stimulus Interleukin-8 Production Activation Of Phospholipase A2 Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Cell Cycle Process Cell Cycle Cellular Response To Stimulus Regulation Of Cell Cycle Viral Process Positive Regulation Of Cell Cycle DNA Strand Renaturation Mitotic Cell Cycle Arrest Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Response To Stimulus Protein Import Into Nucleus, Translocation Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein Complex Assembly Apoptotic Cell Clearance Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Cell Cycle Process Cell Cycle Checkpoint DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Abiotic Stimulus Regulation Of Growth Positive Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process
Tagcloud ?		a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation	9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily
Tagcloud (Difference) ?		a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation	9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily
Tagcloud (Intersection) ?