PLAA and HDAC6

Number of citations of the paper that reports this interaction (PMID 11689694)
75

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PLAA	HDAC6
Gene Name		phospholipase A2-activating protein	histone deacetylase 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Caveola Inclusion Body Aggresome Dynein Complex Axon Dendrite Cell Leading Edge Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phospholipase A2 Activator Activity	Core Promoter Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Enzyme Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Phospholipid Metabolic Process Inflammatory Response Signal Transduction Positive Regulation Of Catalytic Activity	Protein Polyubiquitination Transcription, DNA-templated Protein Deacetylation Misfolded Or Incompletely Synthesized Protein Catabolic Process Intracellular Protein Transport Organelle Organization Negative Regulation Of Microtubule Depolymerization Response To Toxic Substance Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Receptor Activity Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Macroautophagy Histone Deacetylation Lysosome Localization Cellular Response To Heat Peptidyl-lysine Deacetylation Cellular Response To Topologically Incorrect Protein Regulation Of Gene Expression, Epigenetic Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Complex Disassembly Negative Regulation Of Protein Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Oxidoreductase Activity Response To Misfolded Protein Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Hsp90 Deacetylation Response To Growth Factor Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Pathways			HSF1 activation Signaling by NOTCH1 HD Domain Mutants in Cancer Organelle biogenesis and maintenance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Assembly of the primary cilium Cellular response to heat stress Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Schizophrenia ( 20185149)
Protein-Protein Interactions		6 interactors: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP	67 interactors: ADRB2 ADRBK1 ATF3 ATXN3 AURKA BBS10 BCL3 BCOR BRMS1 CDKN1A CORD1 CSNK2A2 CTNNB1 CTTN CYLD EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB G3BP1 HDAC11 HES1 HIST4H4 HSP90AA1 JDP2 KPNA1 LCOR LPXN MAPK3 NACAD NASP NR0B2 NR3C1 PKN1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PTOV1 PXN RELB RUNX2 SIRT2 SYK TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2A TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H VCP VKORC1 ZBTB16 ZNF205
Entrez ID		9373	10013
HPRD ID		04850	02228
Ensembl ID		ENSG00000137055	ENSG00000094631
Uniprot IDs		Q9Y263	Q9UBN7
PDB IDs		2K89 2K8A 2K8B 2K8C 3EBB	3C5K 3GV4 3PHD
Enriched GO Terms of Interacting Partners?		Aggresome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Proteolysis Catabolic Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Protein Catabolic Process Cellular Response To Heat Intracellular Transport Proteolysis Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Hsp90 Deacetylation Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Programmed Cell Death Cellular Response To Topologically Incorrect Protein Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Response To Heat Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of MAPK Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Establishment Of Localization In Cell Protein Polyubiquitination Multicellular Organismal Lipid Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Complex Assembly Response To Temperature Stimulus Interleukin-8 Production Activation Of Phospholipase A2 Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process	Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process RNA Biosynthetic Process Protein Complex Assembly Positive Regulation Of Protein Modification Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cell Death Defense Response Regulation Of Nitrogen Compound Metabolic Process Death Positive Regulation Of Transferase Activity Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response Mitotic Cell Cycle
Tagcloud ?		a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation	amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger
Tagcloud (Difference) ?		a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation	amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger
Tagcloud (Intersection) ?