PLAA and PLA2G1B

Number of citations of the paper that reports this interaction (PubMedID 2052621)
33

Data Source:
HPRD (in vitro)

		PLAA	PLA2G1B
Description		phospholipase A2 activating protein	phospholipase A2 group IB
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Synapse Extracellular Exosome	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Protein Binding Phospholipase A2 Activator Activity Ubiquitin Binding	Phospholipase A2 Activity Signaling Receptor Binding Calcium Ion Binding Phospholipid Binding Hydrolase Activity Bile Acid Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inflammatory Response Signal Transduction Nervous System Development Ubiquitin Recycling Macroautophagy Positive Regulation Of Prostaglandin Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Dendrite Extension Positive Regulation Of Neuron Migration	Innate Immune Response In Mucosa Neutrophil Mediated Immunity Lipid Metabolic Process Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Lipid Catabolic Process Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of D-glucose Import Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Positive Regulation Of Fibroblast Proliferation Arachidonate Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Podocyte Apoptotic Process
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Developmental Lineage of Pancreatic Acinar Cells
Drugs			Fluocinolone acetonide Sulfasalazine Azelastine Hexane-1,6-Diol N-Tridecanoic Acid Cholic Acid P-Anisic Acid Heptanoic acid 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Pyruvaldehyde Lpc-Ether Niflumic acid PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL Medical Cannabis
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Metabolite levels ( 23823483) Schizophrenia ( 20185149)	Bipolar disorder ( 31043756)
Interacting Genes		6 interacting genes: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP	5 interacting genes: BGN CSF3R PLA2G2A PLAA SOCS2
Entrez ID		9373	5319
HPRD ID		04850	01396
Ensembl ID		ENSG00000137055	ENSG00000170890
Uniprot IDs		Q9Y263	P04054
PDB IDs		2K89 2K8A 2K8B 2K8C 3EBB	3ELO 6Q42
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Aggresome Assembly Regulation Of Protein Deubiquitination K48-linked Polyubiquitin Modification-dependent Protein Binding Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex Cellular Response To Misfolded Protein Response To Misfolded Protein Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Catabolic Process Regulation Of Hippo Signaling Cellular Response To Heat Macromolecule Catabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Proteolysis Flavin Adenine Dinucleotide Catabolic Process Organelle Disassembly Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Response To Heat Response To Hydrogen Peroxide Intracellular Protein Transport Positive Regulation Of Podocyte Apoptotic Process VCP-NSFL1C Complex Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Ubiquitin Binding Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Protein-containing Complex Disassembly Positive Regulation Of Oxidative Phosphorylation	Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Articular Cartilage Development Defense Response Regulation Of Developmental Process Granulocyte Colony-stimulating Factor Binding Amelogenesis Regulation Of Neutrophil Activation Intestinal Stem Cell Homeostasis Calcium-dependent Phospholipase A2 Activity Phospholipid Metabolic Process Positive Regulation Of Developmental Process Growth Hormone Receptor Binding Regulation Of Developmental Growth Regulation Of Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Erythropoietin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Growth Hormone Receptor Signaling Pathway JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Positive Regulation Of Neuron Migration Positive Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Ubiquitin Recycling Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Protein Polyubiquitination Phospholipase A2 Activator Activity Regulation Of Protein K63-linked Ubiquitination Low-density Lipoprotein Particle Remodeling Insulin-like Growth Factor Receptor Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mammary Gland Alveolus Development Regulation Of Cell Growth Cytokine-mediated Signaling Pathway Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Positive Regulation Of Dendrite Extension Arachidonate Secretion
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