PLAA and UBXN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, biochemical)

		PLAA	UBXN1
Description		phospholipase A2 activating protein	UBX domain protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex
	Molecular Function	Protein Binding Phospholipase A2 Activator Activity Ubiquitin Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Inflammatory Response Signal Transduction Nervous System Development Ubiquitin Recycling Macroautophagy Positive Regulation Of Prostaglandin Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Dendrite Extension Positive Regulation Of Neuron Migration	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Metabolite levels ( 23823483) Schizophrenia ( 20185149)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP	21 interacting genes: ACOT7 ACVR1 BARD1 BMPR1B BRCA1 CEBPA ENTREP1 HMGB1 HOMER2 PLA2G4A PLAA POLR3C RAD23A SMAD1 SMURF1 TGFBR1 TRIM39 UBC UBE2I UBQLN1 UBQLN2
Entrez ID		9373	51035
HPRD ID		04850	11266
Ensembl ID		ENSG00000137055	ENSG00000162191
Uniprot IDs		Q9Y263	A0A087WTZ5 Q04323
PDB IDs		2K89 2K8A 2K8B 2K8C 3EBB
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Aggresome Assembly Regulation Of Protein Deubiquitination K48-linked Polyubiquitin Modification-dependent Protein Binding Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex Cellular Response To Misfolded Protein Response To Misfolded Protein Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Catabolic Process Regulation Of Hippo Signaling Cellular Response To Heat Macromolecule Catabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Proteolysis Flavin Adenine Dinucleotide Catabolic Process Organelle Disassembly Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Response To Heat Response To Hydrogen Peroxide Intracellular Protein Transport Positive Regulation Of Podocyte Apoptotic Process VCP-NSFL1C Complex Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Ubiquitin Binding Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Protein-containing Complex Disassembly Positive Regulation Of Oxidative Phosphorylation	Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity SMAD Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process I-SMAD Binding Response To Stress Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Kinase Binding Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Primary Metabolic Process BRCA1-B Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Polyubiquitin Modification-dependent Protein Binding Macromolecule Catabolic Process Regulation Of Metabolic Process Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Regulation Of Osteoblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Cell Communication Inflammatory Response Regulation Of Signaling Catabolic Process Regulation Of Protein Metabolic Process Mitotic G2/M Transition Checkpoint Protein Metabolic Process BMP Receptor Activity BRCA1-A Complex
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