XAF1 and TRIML2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		XAF1	TRIML2
Description		XIAP associated factor 1	tripartite motif family like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Sequestering Activity	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Response To Interferon-beta	Protein Ubiquitination Response To Retinoic Acid Innate Immune Response
Pathways		Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Polycystic ovary syndrome ( 25574032)
Interacting Genes		20 interacting genes: AKT1 APP BIRC7 BRCA1 CREBBP ESR1 GLS2 HSPA5 LRSAM1 RFC5 RNF166 SEPHS1 TP53 TRIM21 TRIM50 TRIM54 TRIML2 UBXN2B VCP XIAP	46 interacting genes: ABI2 BLOC1S2 CBY2 CCDC146 CCHCR1 CCNH CDR2 CTBP2 EIF2B1 EIF3M FAM90A1 FAM9C HGS ING5 ITGB3BP KRT15 KRT24 KRT27 KRT31 KRT34 KRT38 KRT75 MBD3L2 MBD3L3 MEOX1 MEOX2 NECAB2 NFKBID NUP62 PICK1 POLR1H POU6F2 SH2D4A STN1 SUMO2 SYCE2 TBC1D25 TCF4 TFIP11 TRIM54 TSEN54 TSG101 USHBP1 XAF1 ZBED1 ZFHX3
Entrez ID		54739	205860
HPRD ID		06978	08696
Ensembl ID		ENSG00000132530	ENSG00000179046
Uniprot IDs		Q6GPH4	A0A804HJA0 B7ZLC3 Q8N7C3
PDB IDs		2LXW
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Metabolic Process Macromolecule Metabolic Process Zinc Ion Binding Regulation Of Post-translational Protein Modification Protein Modification Process Response To Stress Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Transferase Activity Identical Protein Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intracellular Signaling Cassette Protein K6-linked Ubiquitination Metal Ion Binding 14-3-3 Protein Binding Cytoplasm Proteolysis Involved In Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-protein Transferase Activity ER-nucleus Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Macromolecule Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Nitric Oxide Metabolic Process Immune System Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Cycle Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Defense Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transcription Coactivator Binding Stress Granule Disassembly Cellular Response To Stress Regulation Of Small Molecule Metabolic Process Negative Regulation Of Apoptotic Process	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Protein Binding Supramolecular Fiber Organization Somite Specification Epithelial Cell Differentiation Cytoskeleton Morphogenesis Of An Epithelium Cytoskeleton Organization Organelle Organization Cellular Developmental Process Tissue Morphogenesis Segment Specification Somite Development Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion
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