XAF1

Description		XIAP associated factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Sequestering Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Response To Interferon-beta
Pathways		Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Interacting Genes		20 interacting genes: AKT1 APP BIRC7 BRCA1 CREBBP ESR1 GLS2 HSPA5 LRSAM1 RFC5 RNF166 SEPHS1 TP53 TRIM21 TRIM50 TRIM54 TRIML2 UBXN2B VCP XIAP
Entrez ID		54739
HPRD ID		06978
Ensembl ID		ENSG00000132530
Uniprot IDs		Q6GPH4
PDB IDs		2LXW
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Metabolic Process Macromolecule Metabolic Process Zinc Ion Binding Regulation Of Post-translational Protein Modification Protein Modification Process Response To Stress Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Transferase Activity Identical Protein Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intracellular Signaling Cassette Protein K6-linked Ubiquitination Metal Ion Binding 14-3-3 Protein Binding Cytoplasm Proteolysis Involved In Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-protein Transferase Activity ER-nucleus Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Macromolecule Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Nitric Oxide Metabolic Process Immune System Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Cycle Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Defense Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transcription Coactivator Binding Stress Granule Disassembly Cellular Response To Stress Regulation Of Small Molecule Metabolic Process Negative Regulation Of Apoptotic Process
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