XAF1 and XIAP

Number of citations of the paper that reports this interaction (PMID 11175744)
54

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		XAF1	XIAP
Gene Name		XIAP associated factor 1	X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule
	Molecular Function	Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Apoptotic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Complex Assembly Response To Interferon-beta Type I Interferon Signaling Pathway	Apoptotic Process Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Signaling by Wnt deactivation of the beta-catenin transactivating complex Apoptotic factor-mediated response TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Intrinsic Pathway for Apoptosis
Drugs			1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP CREBBP RNF114 TP53 XIAP	67 interactors: ACVRL1 AFP AIFM1 AKT1 AKT2 BIRC5 BRCA1 CASP10 CASP3 CASP7 CASP9 CHEK1 CKS1B COMMD1 DIABLO DTX3 DYNLL2 ELAVL1 ERCC3 GSPT1 HTRA1 HTRA2 IKBKE INPP5D LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 NEK6 NOD1 NOD2 NOTCH1 RAF1 RFC5 RIPK1 RIPK2 RIPK3 RIPK4 SEPT4 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TRAF6 TRIM32 TRIM8 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C WDYHV1 XAF1
Entrez ID		54739	331
HPRD ID		06978	02094
Ensembl ID		ENSG00000132530	ENSG00000101966
Uniprot IDs		B3KPW1 Q6GPH4	B2R9R2 P98170
PDB IDs		2LXW	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Copper Ion Homeostasis Negative Regulation Of Hydrolase Activity Neuron Apoptotic Process Neuron Death Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Negative Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Transition Metal Ion Homeostasis Negative Regulation Of Macromitophagy Synaptic Growth At Neuromuscular Junction Positive Regulation Of Protein Linear Polyubiquitination Oligodendrocyte Apoptotic Process Negative Regulation Of Helicase Activity N-terminal Peptidyl-lysine Acetylation Collateral Sprouting In Absence Of Injury Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Peptidyl-tyrosine Phosphorylation Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Signal Transduction Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Germ-line Stem Cell Maintenance Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Peptidase Activity Regulation Of Signaling Mitochondrial DNA Repair Axon Choice Point Recognition Positive Regulation Of Cell Cycle Cell Surface Receptor Signaling Pathway Negative Regulation Of Neurogenesis Immune Response Response To Hypoxia	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Apoptotic Process Activation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Stress Positive Regulation Of Protein Modification Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Protein Polyubiquitination Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction By Phosphorylation Innate Immune Response Regulation Of Signal Transduction Cellular Protein Modification Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Metabolic Process Protein Ubiquitination Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Signaling Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xiap zinc znf313	anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 zinc znf313	anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl
Tagcloud (Intersection) ?		xiap