XAF1 and BIRC7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		XAF1	BIRC7
Description		XIAP associated factor 1	baculoviral IAP repeat containing 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Sequestering Activity	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Response To Interferon-beta	Lens Development In Camera-type Eye Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Regulation Of Natural Killer Cell Apoptotic Process
Pathways		Interferon alpha/beta signaling	Regulation of MITF-M-dependent genes involved in apoptosis
Drugs
Diseases
GWAS
Interacting Genes		20 interacting genes: AKT1 APP BIRC7 BRCA1 CREBBP ESR1 GLS2 HSPA5 LRSAM1 RFC5 RNF166 SEPHS1 TP53 TRIM21 TRIM50 TRIM54 TRIML2 UBXN2B VCP XIAP	37 interacting genes: AURKC BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 DDX6 DIABLO FAM124B GTF2A1 HTRA2 KANK2 LCOR LMO4 NTAQ1 PHF1 POLR1C PRR35 PSMB1 PTCD3 QARS1 SOX5 TEPSIN TLE5 TNPO2 TSGA10IP TTPA UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2I UBE2K USP2 VPS37C XAF1
Entrez ID		54739	79444
HPRD ID		06978	05761
Ensembl ID		ENSG00000132530	ENSG00000101197
Uniprot IDs		Q6GPH4	Q96CA5
PDB IDs		2LXW	1OXN 1OXQ 1OY7 1TW6 2I3H 2I3I 3F7G 3F7H 3F7I 3GT9 3GTA 3UW5 4AUQ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Metabolic Process Macromolecule Metabolic Process Zinc Ion Binding Regulation Of Post-translational Protein Modification Protein Modification Process Response To Stress Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Transferase Activity Identical Protein Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intracellular Signaling Cassette Protein K6-linked Ubiquitination Metal Ion Binding 14-3-3 Protein Binding Cytoplasm Proteolysis Involved In Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-protein Transferase Activity ER-nucleus Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Macromolecule Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Nitric Oxide Metabolic Process Immune System Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Cycle Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Defense Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transcription Coactivator Binding Stress Granule Disassembly Cellular Response To Stress Regulation Of Small Molecule Metabolic Process Negative Regulation Of Apoptotic Process	Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Metabolic Process Macromolecule Catabolic Process Fibroblast Apoptotic Process Iron-sulfur Cluster Assembly Complex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Neuron Apoptotic Process Nucleus Cysteine-type Endopeptidase Activity Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Iron-sulfur Cluster Assembly Execution Phase Of Apoptosis Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Cytosol Negative Regulation Of Biosynthetic Process Glial Cell Apoptotic Process Protein Maturation Post-translational Protein Modification Response To Interferon-beta Response To Anesthetic Negative Regulation Of Metabolic Process Cell Redox Homeostasis Protein Binding Negative Regulation Of Macromolecule Metabolic Process Leukocyte Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Cysteine-type Peptidase Activity Response To Cobalt Ion Ubiquitin-protein Transferase Activity [2Fe-2S] Cluster Assembly CD40 Receptor Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Intracellular Iron Ion Homeostasis Protein Modification Process Positive Regulation Of Neuron Apoptotic Process Catabolic Process Apoptotic Process Intrinsic Apoptotic Signaling Pathway Histone Methyltransferase Binding Negative Regulation Of RNA Metabolic Process Protein Processing Protein Poly-ADP-ribosylation Programmed Cell Death
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?