XAF1 and SEPHS1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		XAF1	SEPHS1
Name		XIAP associated factor 1	selenophosphate synthetase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Sequestering Activity	Nucleotide Binding Selenide, Water Dikinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Response To Interferon-beta	Selenocysteine Biosynthetic Process Protein Modification Process
Pathways		Interferon alpha/beta signaling	None
GWAS		No GWAS studies recorded	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Metabolite levels ( 23823483 ) Schizophrenia x sex interaction ( 34099189 )
Interacting Genes		20 interacting genes: AKT1 APP BIRC7 BRCA1 CREBBP ESR1 GLS2 HSPA5 LRSAM1 RFC5 RNF166 SEPHS1 TP53 TRIM21 TRIM50 TRIM54 TRIML2 UBXN2B VCP XIAP	18 interacting genes: CDCA4 CRMP1 DEPDC7 ERG28 GBP2 IGSF21 PLAGL2 QRICH1 SAT1 SLC35F6 SPACA9 UNC119 XAF1 ZBTB25 ZNF202 ZNF276 ZNF474 ZNF526
Entrez ID		54739	22929
HPRD ID		06978	02944
Ensembl ID		ENSG00000132530	ENSG00000086475
Uniprot IDs		Q6GPH4	P49903
PDB IDs		2LXW	3FD5 3FD6
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Ubiquitination Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Metabolic Process Macromolecule Metabolic Process Zinc Ion Binding Regulation Of Post-translational Protein Modification Protein Modification Process Response To Stress Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Transferase Activity Identical Protein Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intracellular Signaling Cassette Protein K6-linked Ubiquitination Metal Ion Binding 14-3-3 Protein Binding Cytoplasm Proteolysis Involved In Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-protein Transferase Activity ER-nucleus Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Macromolecule Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Nitric Oxide Metabolic Process Immune System Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Cycle Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Defense Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transcription Coactivator Binding Stress Granule Disassembly Cellular Response To Stress Regulation Of Small Molecule Metabolic Process Negative Regulation Of Apoptotic Process	None