RHOG and SMAD1

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		RHOG	SMAD1
Gene Name		ras homolog family member G	SMAD family member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Intracellular Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Protein Kinase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Cell Proliferation Rac Protein Signal Transduction Actin Cytoskeleton Organization Platelet Activation Activation Of Rac GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Ruffle Assembly	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Response To Organonitrogen Compound Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Wound Healing Response To Drug Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Dendrite Morphogenesis Cartilage Development Cardiac Muscle Cell Proliferation Bone Development Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse	Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: ARHGDIA ARHGDIG DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3	138 interactors: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APP AR ARHGEF6 ARL4D BMPR1A BTBD2 BTG2 CAMSAP1 CDK7 CDK9 CHMP3 COL4A1 DVL1 ECSIT EIF2AK4 ELP3 EP300 ERBB2IP EWSR1 FBXL12 FBXO30 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC GSK3B HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ICK ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MKL2 NAT9 NEDD4 NEDD9 NEUROG1 NKX3-2 NOTCH2 OAZ1 OAZ3 PAK1 PARD3B PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STUB1 SUV39H1 TCF20 TGFBR1 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4
Entrez ID		391	4086
HPRD ID		01537	03356
Ensembl ID		ENSG00000177105	ENSG00000170365
Uniprot IDs		P84095 Q6ICQ8	Q15797
PDB IDs			1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Phagocytosis Signal Transduction Apoptotic Process Programmed Cell Death Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rho GTPase Activity Cellular Response To Stimulus Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Response To Stress Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Chemotaxis Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway	Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction Regulation Of Signaling Cellular Response To Growth Factor Stimulus Pattern Specification Process Signaling Transcription From RNA Polymerase II Promoter
Tagcloud ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo
Tagcloud (Difference) ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo
Tagcloud (Intersection) ?