RHOG and ELMO1

Number of citations of the paper that reports this interaction (PubMedID 12879077)
0

Data Source:
HPRD (in vivo)

		RHOG	ELMO1
Description		ras homolog family member G	engulfment and cell motility 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Cell Chemotaxis Activation Of GTPase Activity Regulation Of Postsynapse Assembly Regulation Of Ruffle Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Rac Protein Signal Transduction Actin Filament-based Process Actin Cytoskeleton Organization Cell Motility Regulation Of Postsynapse Assembly
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Eosinophilic esophagitis ( 34506852) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)	Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 25920553 30572963 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 30572963) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		24 interacting genes: ARHGDIA ARHGDIG CCR2 CEBPA DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 RSPH1 SMAD1 SMAD4 TGFBR1 UBC VAV1 VAV2 VAV3	11 interacting genes: ADGRB1 ADGRB3 APBB1 CEBPA DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		391	9844
HPRD ID		01537	12102
Ensembl ID		ENSG00000177105	ENSG00000155849
Uniprot IDs		P84095 Q6ICQ8	A4D1X5 Q92556
PDB IDs		6UKA 7Y4A 8XM7 8ZJ2	2RQR 2VSZ 3A98 6JPP 6TGB 6TGC 7DPA 7Y4A 8JHK 8XM7 8ZJ2 8ZJI 8ZJJ 8ZJK 8ZJL 8ZJM
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette Guanyl-nucleotide Exchange Factor Activity Small GTPase-mediated Signal Transduction Signal Transduction GTPase Activator Activity Regulation Of Small GTPase Mediated Signal Transduction Phagocytosis I-SMAD Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rho GDP-dissociation Inhibitor Activity Cell Motility Fc-gamma Receptor Signaling Pathway Cell Migration Guanyl-nucleotide Exchange Factor Complex SMAD Protein Complex Heteromeric SMAD Protein Complex Fc Receptor Signaling Pathway Cytosol Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Chemotaxis Cellular Response To Xenobiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Locomotion Platelet Activation Cytoplasm Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Chemotaxis Regulation Of Cell Size Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-6-mediated Signaling Pathway Cardiac Conduction System Development MAPK Cascade Endocytosis Integrin-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Extracellular Matrix Assembly SH3 Domain Binding SMAD Protein Signal Transduction Small GTPase Binding Positive Regulation Of Extracellular Matrix Organization Response To Xenobiotic Stimulus	Myoblast Fusion Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Regulation Of Synapse Assembly Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Regulation Of Synapse Organization Phagocytosis Regulation Of Cell Shape Regulation Of Anatomical Structure Morphogenesis Endocytosis Phagocytosis, Engulfment Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Cellular Component Organization Regulation Of Postsynapse Assembly Postsynapse Membrane Invagination Regulation Of Cell Morphogenesis Import Into Cell Developmental Process GTPase Activator Activity Small GTPase-mediated Signal Transduction Cell Projection Positive Regulation Of Synapse Assembly RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Small GTPase Binding Actin Cytoskeleton Organization Cytoskeleton Response To Vitamin B2 C/EBP Complex Plasma Membrane Actin Filament-based Process Intracellular Signaling Cassette Cell Migration Regulation Of Developmental Process CHOP-C/EBP Complex Integrin-mediated Signaling Pathway Membrane Raft Polarization Regulation Of Phagocytosis Myeloid Dendritic Cell Activation Involved In Immune Response Leukocyte Migration Involved In Immune Response Positive Regulation Of Cell Junction Assembly Focal Adhesion White Fat Cell Proliferation Respiratory Burst After Phagocytosis Cell Recognition Regulation Of GTPase Activity Intracellular Signal Transduction
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