RHOG and ARHGDIA

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RHOG	ARHGDIA
Description		ras homolog family member G	Rho GDP dissociation inhibitor alpha
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Immunological Synapse Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Cell Chemotaxis Activation Of GTPase Activity Regulation Of Postsynapse Assembly Regulation Of Ruffle Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Rho Protein Signal Transduction Regulation Of Protein Localization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Semaphorin-plexin Signaling Pathway Regulation Of Synaptic Vesicle Cycle
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	Axonal growth inhibition (RHOA activation) Axonal growth stimulation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Eosinophilic esophagitis ( 34506852) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)
Interacting Genes		24 interacting genes: ARHGDIA ARHGDIG CCR2 CEBPA DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 RSPH1 SMAD1 SMAD4 TGFBR1 UBC VAV1 VAV2 VAV3	41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B CEBPA EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		391	396
HPRD ID		01537	03565
Ensembl ID		ENSG00000177105	ENSG00000141522
Uniprot IDs		P84095 Q6ICQ8	J3QQX2 P52565 V9HWE8
PDB IDs		6UKA 7Y4A 8XM7 8ZJ2	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80 8X8T
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette Guanyl-nucleotide Exchange Factor Activity Small GTPase-mediated Signal Transduction Signal Transduction GTPase Activator Activity Regulation Of Small GTPase Mediated Signal Transduction Phagocytosis I-SMAD Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rho GDP-dissociation Inhibitor Activity Cell Motility Fc-gamma Receptor Signaling Pathway Cell Migration Guanyl-nucleotide Exchange Factor Complex SMAD Protein Complex Heteromeric SMAD Protein Complex Fc Receptor Signaling Pathway Cytosol Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Chemotaxis Cellular Response To Xenobiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Locomotion Platelet Activation Cytoplasm Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Chemotaxis Regulation Of Cell Size Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-6-mediated Signaling Pathway Cardiac Conduction System Development MAPK Cascade Endocytosis Integrin-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Extracellular Matrix Assembly SH3 Domain Binding SMAD Protein Signal Transduction Small GTPase Binding Positive Regulation Of Extracellular Matrix Organization Response To Xenobiotic Stimulus	Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Negative Regulation Of Cellular Component Organization Cellular Response To Stress Erythrocyte Enucleation Regulation Of Primary Metabolic Process Actin Filament Organization Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Shelterin Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cytoskeleton Organization Post-translational Protein Modification Response To Stress Positive Regulation Of Metabolic Process Protein Modification Process Macromolecule Catabolic Process Positive Regulation Of Lamellipodium Assembly Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Developmental Process Negative Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Nuclear Telomere Cap Complex Positive Regulation Of Developmental Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Lamellipodium Assembly Fibroblast Apoptotic Process Positive Regulation Of Cell Adhesion Regulation Of Macromolecule Biosynthetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Telomere Capping Regulation Of Metabolic Process Small GTPase-mediated Signal Transduction Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Signaling Cassette
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