RHOG and VAV3

Number of citations of the paper that reports this interaction (PubMedID 10523675)
35

Data Source:
HPRD (in vitro)

		RHOG	VAV3
Description		ras homolog family member G	vav guanine nucleotide exchange factor 3
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Immunological Synapse Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Cell Chemotaxis Activation Of GTPase Activity Regulation Of Postsynapse Assembly Regulation Of Ruffle Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Angiogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle Fusion DNA Damage Response Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Cell Projection Assembly Lamellipodium Assembly Platelet Activation Neutrophil Chemotaxis Positive Regulation Of B Cell Proliferation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Adhesion B Cell Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle	GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME
Drugs
Diseases
GWAS		Eosinophilic esophagitis ( 34506852) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Asthma and hay fever ( 24388013) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Differentiated thyroid cancer ( 28703219) Eosinophil percentage of white cells ( 32888494) Facial wrinkles (principal components analysis) ( 33959940) Hashimoto thyroiditis versus Graves' disease ( 25429627) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965 30367059 22493691) IgA nephropathy ( 25305756) Medication use (thyroid preparations) ( 31015401) Night sleep phenotypes ( 27126917) Papillary thyroid cancer ( 28703219) Plasma thyroid-stimulating hormone levels ( 24722205) Refractive error ( 32231278) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		24 interacting genes: ARHGDIA ARHGDIG CCR2 CEBPA DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 RSPH1 SMAD1 SMAD4 TGFBR1 UBC VAV1 VAV2 VAV3	25 interacting genes: AR CBLB EGFR ERBB2 ERBB3 ERBB4 ESR1 GAB1 GRB2 IGF1R INSR KIT LCP2 MET PIK3R1 PLCG1 RAC1 RHOA RHOG RINT1 ROS1 SH3BP2 SHC1 ZRANB1 ZYX
Entrez ID		391	10451
HPRD ID		01537	05706
Ensembl ID		ENSG00000177105	ENSG00000134215
Uniprot IDs		P84095 Q6ICQ8	Q9UKW4
PDB IDs		6UKA 7Y4A 8XM7 8ZJ2	2D86
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette Guanyl-nucleotide Exchange Factor Activity Small GTPase-mediated Signal Transduction Signal Transduction GTPase Activator Activity Regulation Of Small GTPase Mediated Signal Transduction Phagocytosis I-SMAD Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rho GDP-dissociation Inhibitor Activity Cell Motility Fc-gamma Receptor Signaling Pathway Cell Migration Guanyl-nucleotide Exchange Factor Complex SMAD Protein Complex Heteromeric SMAD Protein Complex Fc Receptor Signaling Pathway Cytosol Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Chemotaxis Cellular Response To Xenobiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Locomotion Platelet Activation Cytoplasm Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Chemotaxis Regulation Of Cell Size Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-6-mediated Signaling Pathway Cardiac Conduction System Development MAPK Cascade Endocytosis Integrin-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Extracellular Matrix Assembly SH3 Domain Binding SMAD Protein Signal Transduction Small GTPase Binding Positive Regulation Of Extracellular Matrix Organization Response To Xenobiotic Stimulus	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Tyrosine Kinase Activity Intracellular Signal Transduction Receptor Complex Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Neurotrophin TRKA Receptor Binding Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Insulin-like Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Insulin Receptor Substrate Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphate Metabolic Process Intracellular Signaling Cassette Regulation Of Developmental Process Protein Kinase Activity Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling ErbB-3 Class Receptor Binding Insulin Binding Positive Regulation Of Metabolic Process Plasma Membrane Positive Regulation Of Protein Phosphorylation ERBB2 Signaling Pathway Basal Plasma Membrane Positive Regulation Of Protein Modification Process Regulation Of Cell Migration Positive Regulation Of Phosphorylation Regulation Of Cell Motility
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