RHOG and IQGAP2

Number of citations of the paper that reports this interaction (PMID 12376551)
34

Data Source:
HPRD (in vitro)

		RHOG	IQGAP2
Gene Name		ras homolog family member G	IQ motif containing GTPase activating protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Cytoplasm Microtubule Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Filamentous Actin Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Actin Binding GTPase Inhibitor Activity Ras GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Rho GTPase Binding Rac GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Cell Proliferation Rac Protein Signal Transduction Actin Cytoskeleton Organization Platelet Activation Activation Of Rac GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Ruffle Assembly	Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Ras GTPase Activity Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Catalytic Activity Thrombin Receptor Signaling Pathway
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS			Hearing impairment ( 20068591) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		19 interactors: ARHGDIA ARHGDIG DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3	5 interactors: ACTR2 CALM1 CDC42 RAC1 RHOG
Entrez ID		391	10788
HPRD ID		01537	09253
Ensembl ID		ENSG00000177105	ENSG00000145703
Uniprot IDs		P84095 Q6ICQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Phagocytosis Signal Transduction Apoptotic Process Programmed Cell Death Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rho GTPase Activity Cellular Response To Stimulus Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Response To Stress Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Chemotaxis Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway	Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Blood Coagulation Hemostasis Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Projection Assembly Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Neuron Projection Morphogenesis Actin Filament-based Process Response To External Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Cell Morphogenesis Involved In Differentiation Platelet Activation Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Phagocytosis Neuron Development Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Substantia Nigra Development Neuron Differentiation Cytoskeleton Organization Regulation Of Protein Complex Assembly Cell Projection Organization Locomotion Immune Response
Tagcloud ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	293t androgen bph cadherin candidate collectively concept du145 ectopic glands gleason hepatocellular intraepithelial lncap mechanistically neoplasia pc pc3 pcs pin prostate prostatic substantially suppress suppresses tumorigenesis tumorigenic tumours xenograft
Tagcloud (Difference) ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	293t androgen bph cadherin candidate collectively concept du145 ectopic glands gleason hepatocellular intraepithelial lncap mechanistically neoplasia pc pc3 pcs pin prostate prostatic substantially suppress suppresses tumorigenesis tumorigenic tumours xenograft
Tagcloud (Intersection) ?