RHOG and ECT2

Number of citations of the paper that reports this interaction (PMID 12376551)
34

Data Source:
HPRD (in vitro)

		RHOG	ECT2
Gene Name		ras homolog family member G	epithelial cell transforming 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Cell Proliferation Rac Protein Signal Transduction Actin Cytoskeleton Organization Platelet Activation Activation Of Rac GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Ruffle Assembly	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		19 interactors: ARHGDIA ARHGDIG DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3	37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2
Entrez ID		391	1894
HPRD ID		01537	11860
Ensembl ID		ENSG00000177105	ENSG00000114346
Uniprot IDs		P84095 Q6ICQ8	G5E9L8 Q9H8V3
PDB IDs			3L46
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Phagocytosis Signal Transduction Apoptotic Process Programmed Cell Death Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rho GTPase Activity Cellular Response To Stimulus Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Response To Stress Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Chemotaxis Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition
Tagcloud ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Difference) ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Intersection) ?