NR4A1 and RXRG

Number of citations of the paper that reports this interaction (PMID 12082103)
25

Data Source:
HPRD (in vivo, in vitro)

		NR4A1	RXRG
Gene Name		nuclear receptor subfamily 4, group A, member 1	retinoid X receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Nucleoplasm
	Molecular Function	DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Steroid Hormone Receptor Activity 9-cis Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Intracellular Receptor Signaling Pathway Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Transcription Initiation From RNA Polymerase II Promoter Peripheral Nervous System Development Heart Development Skeletal Muscle Tissue Development Gene Expression Neuron Differentiation Regulation Of Myelination Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Protein Homotetramerization Transmembrane Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Nuclear Receptor transcription pathway Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Generic Transcription Pathway PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs			Adapalene Bexarotene Acitretin Alitretinoin Tretinoin Etretinate
Diseases
GWAS			AIDS ( 19754311) Menarche (age at onset) ( 21102462) Personality dimensions ( 21368711)
Protein-Protein Interactions		83 interactors: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579	29 interactors: CAMK2B CEBPZ CHGB CREBBP DCK HOXD4 ITGB3BP LRSAM1 MAP4 MPPED2 NCOA6 NCOR2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR4A1 PNO1 PPARA PPARD PPARG RARA RARB RARG SRF THRA THRB VDR
Entrez ID		3164	6258
HPRD ID		00744	01579
Ensembl ID		ENSG00000123358	ENSG00000143171
Uniprot IDs		F5GXF0 P22736	F1D8Q7 F1T097 P48443
PDB IDs		2QW4 3V3E 3V3Q	2GL8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Death Death Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stimulus Intracellular Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Regulation Of Cell Death Signal Transduction Regulation Of Apoptotic Process Regulation Of Signaling Signaling Cellular Response To Stimulus Regulation Of Signal Transduction Cell Communication Apoptotic Signaling Pathway Response To Stress RNA Biosynthetic Process Regulation Of Intracellular Transport Epithelium Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Intracellular Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Placenta Development Reproductive Structure Development Regulation Of Metabolic Process Reproductive System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Toll-like Receptor TLR6:TLR2 Signaling Pathway	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Hormone Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Transcription, DNA-templated Response To Organic Cyclic Compound Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cholesterol Storage Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process
Tagcloud ?		1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma	band bands chromosome chromosomes cosmid cosmids cytogenetic encoded establishing heterodimeric location loci pairwise partners proximity q22 q23 q34 reference respond retinoic retinoid rxra rxrb rxrs separate tr vdr
Tagcloud (Difference) ?		1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma	band bands chromosome chromosomes cosmid cosmids cytogenetic encoded establishing heterodimeric location loci pairwise partners proximity q22 q23 q34 reference respond retinoic retinoid rxra rxrb rxrs separate tr vdr
Tagcloud (Intersection) ?