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NR4A1 and YWHAZ
Number of citations of the paper that reports this interaction (PubMedID
16223362
)
49
Data Source:
HPRD
(in vitro)
NR4A1
YWHAZ
Description
nuclear receptor subfamily 4 group A member 1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Image
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Nuclear Speck
Nuclear Membrane
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Focal Adhesion
Vesicle
Melanosome
Extracellular Exosome
Blood Microparticle
Hippocampal Mossy Fiber To CA3 Synapse
Glutamatergic Synapse
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Lipopolysaccharide Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Nuclear Glucocorticoid Receptor Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
RNA Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Transmembrane Transporter Binding
Cadherin Binding
Phosphoserine Residue Binding
DNA-binding Transcription Factor Binding
Protein Sequestering Activity
Biological Process
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Apoptotic Process
Inflammatory Response
Signal Transduction
Intracellular Receptor Signaling Pathway
Detection Of Lipopolysaccharide
Endothelial Cell Chemotaxis
Skeletal Muscle Cell Differentiation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Macrophage Activation
Positive Regulation Of Apoptotic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Fat Cell Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Corticotropin-releasing Hormone Stimulus
Non-canonical Inflammasome Complex Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Respiratory System Process
Protein Phosphorylation
Protein Targeting
Lysosome Organization
Signal Transduction
Synaptic Target Recognition
Intracellular Protein Localization
Lung Development
Regulation Of Protein Stability
Cellular Response To Nutrient Levels
Tube Formation
TORC1 Signaling
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Innate Immune Response
Establishment Of Golgi Localization
ERK1 And ERK2 Cascade
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Synapse Maturation
Golgi Reassembly
Antibacterial Innate Immune Response
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of TORC1 Signaling
Regulation Of Lysosome Organization
Pathways
AKT phosphorylates targets in the nucleus
Nuclear Receptor transcription pathway
Constitutive Signaling by AKT1 E17K in Cancer
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Deactivation of the beta-catenin transactivating complex
Rap1 signalling
GP1b-IX-V activation signalling
KSRP (KHSRP) binds and destabilizes mRNA
Interleukin-3, Interleukin-5 and GM-CSF signaling
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling
Regulation of localization of FOXO transcription factors
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Adventurousness (
30643258
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Body mass index (
25673413
)
Chronotype (
30696823
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
General risk tolerance (MTAG) (
30643258
)
High light scatter reticulocyte count (
32888494
)
Interleukin-10 levels (
22205395
)
Interacting Genes
86 interacting genes:
ABCA5
ABCB11
ABCC13
ABCC6
ABCG8
AKT1
ANKIB1
ARHGEF10L
ARHGEF5
ATM
ATXN1
BBS10
BCL2
BCL2A1
BCL2L10
CD2AP
CDKN2D
CHD1L
CHD3
CHEK2
CPT1A
CUTA
DIABLO
EP300
FAF1
FXYD3
GADD45GIP1
GK
GLOD4
GLUD1
HADHA
HES1
HIF1A
HNRNPA2B1
HSP90AB1
KAT2B
KRTAP10-1
KRTAP10-5
LONRF1
LSS
MAP3K1
MAPK1
MAPK8
MED1
MED31
NACAD
NCOA1
NCOA2
NCOA3
NCOR2
NDRG1
NFKB1
NR3C1
PGBD1
PML
POLA2
PPARG
PPBP
PPM1A
PRDX4
PRDX6
RBL1
ROBO2
RPL7
RPS6KA1
RPS6KA3
RPS6KA5
RPS6KA6
RTN4
RXRA
RXRG
SERPINA4
SERPING1
SOCS4
STAT3
SUGT1
TCF4
TP53
TRAF2
TRIM28
TUBB4A
VASP
VHL
YWHAZ
ZNF331
ZNF579
204 interacting genes:
AANAT
ABL1
ADAM22
ADRA2A
ADRA2B
ADRA2C
AKAP13
AKT1
APP
ARHGEF2
ATP5F1A
ATXN1
BAD
BCAR1
BCR
BRAF
BSPRY
CBL
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CEP126
CEP131
CFL1
CGNL1
CLIC4
COP1
CPAP
CRBN
CRTC2
CSF2RB
CSNK1A1
CSNK1D
DFFA
DISC1
EFNB3
EGFR
EIF3A
ENO1
EP300
EPB41L1
EPB41L3
ERBB2
ERBB3
EXO1
FAM13B
FHOD1
FNDC3B
FOXO1
FOXO3
FOXO4
GABARAPL2
GABBR1
GCH1
GP1BA
GP1BB
GP5
GSK3B
HDAC4
HDAC9
HMGN1
HSP90AA1
HSPA1A
HSPA1B
HSPB1
HSPB6
IGF1R
IL9R
ING1
INPP5A
IRAG2
IRS1
IRS2
KANK1
KCNK15
KCNK3
KCNK9
KIAA0232
KIAA0930
KIF1C
KIF5B
KLC2
KLC4
KLF11
KRT18
KSR1
LARP1
LATS2
LCP2
LIMK1
LNX1
MADD
MAP2K5
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAPK8
MAPKAPK2
MAPT
MARK2
MARK3
MARK4
MDM4
MEF2C
MINK1
MLF1
MPHOSPH9
MSL2
MST1R
MTNR1A
MYH9
NCAM2
NEDD4L
NFATC2
NFATC4
NR4A1
PAK1
PAK4
PARD3
PARD6A
PARD6B
PCNT
PDC
PFKFB2
PIAS1
PPP1CC
PPP1R14A
PPP1R3D
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCI
PRKCZ
PRLR
PRMT5
PSMA5
PTPN13
PTPRO
RAF1
RALGPS2
RAP1GAP2
RASAL3
REM1
RGS3
RIN1
RPRD1A
RRAD
SAMSN1
SH3GL1
SIK1
SIK3
SIMC1
SLC8A2
SNAPIN
SNX24
SORBS2
SQSTM1
SSX2IP
STK25
STK38
SYN2
SYNPO
SYNPO2
TAB2
TBC1D7
TBXA2R
TERT
TH
TJP2
TLK2
TNFAIP3
TNS1
TP53
TPD52L1
TPH1
TRA2B
TRIM21
TSC1
TSC2
TUBB
UBC
UCHL5
UCP2
UCP3
USP8
VCP
VIM
WEE1
WNK1
WNK2
WWTR1
XRCC6
YAP1
YWHAE
ZNF839
Entrez ID
3164
7534
HPRD ID
00744
03183
Ensembl ID
ENSG00000123358
ENSG00000164924
Uniprot IDs
F5GXF0
P22736
Q6ZMM6
D0PNI1
P63104
PDB IDs
2QW4
3V3E
3V3Q
4JGV
4KZI
4KZJ
4KZM
4RE8
4REE
4REF
4RZE
4RZF
4RZG
4WHF
4WHG
6KZ5
6LC1
8WUY
8Y7L
1IB1
1QJA
1QJB
2C1J
2C1N
2O02
2WH0
3CU8
3NKX
3RDH
4BG6
4FJ3
4HKC
4IHL
4N7G
4N7Y
4N84
4WRQ
4ZDR
5D2D
5D3F
5EWZ
5EXA
5J31
5JM4
5M35
5M36
5M37
5NAS
5ULO
5WXN
5XY9
6EF5
6EJL
6EWW
6F08
6F09
6FN9
6FNA
6FNB
6FNC
6Q0K
6RLZ
6U2H
6XAG
6YMO
6YO8
6YOS
6ZFD
6ZFG
7D8H
7D8P
7D9V
7MFD
7MFE
7MFF
7Q16
7ZIT
8A9G
8AH2
8QDV
8WE2
8WF6
9FUM
9FVL
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
TOR Signaling
Positive Regulation Of RNA Metabolic Process
TORC1 Signaling
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Intracellular Receptor Signaling Pathway
Response To Lipid
Peroxisome Proliferator Activated Receptor Signaling Pathway
Nuclear Receptor-mediated Signaling Pathway
Nuclear Receptor Binding
Ubiquitin Protein Ligase Binding
Programmed Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cell Death
Positive Regulation Of Biosynthetic Process
Protein-containing Complex
Cellular Response To Stress
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Small Molecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
Apoptotic Process
Negative Regulation Of Programmed Cell Death
Nucleoplasm
Intrinsic Apoptotic Signaling Pathway
Response To Nutrient Levels
Identical Protein Binding
MRNA Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Stability
Response To Decreased Oxygen Levels
Negative Regulation Of RNA Metabolic Process
Response To Hormone
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Developmental Process
Response To Oxygen Levels
MRNA Transcription By RNA Polymerase II
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Primary Metabolic Process
Cytoplasm
Intracellular Signal Transduction
Protein Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Phosphorylation
Cytosol
Regulation Of Intracellular Signal Transduction
Phosphorylation
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Signal Transduction
Positive Regulation Of Signal Transduction
ATP Binding
Intracellular Signaling Cassette
Regulation Of Protein Modification Process
Protein Modification Process
Regulation Of Cellular Component Organization
Regulation Of Programmed Cell Death
Nucleotide Binding
Regulation Of Protein Localization
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Apoptotic Process
Positive Regulation Of Protein Metabolic Process
Transferase Activity
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Stress
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Regulation Of Phosphorus Metabolic Process
Regulation Of Multicellular Organismal Process
Protein Kinase Binding
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Protein Localization
Protein Metabolic Process
Regulation Of Cell Cycle
Cell Surface Receptor Signaling Pathway
Response To Stress
Protein-containing Complex
MAPK Cascade
Positive Regulation Of Cellular Component Organization
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Tagcloud (Intersection)
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