NR4A1 and CPT1A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NR4A1	CPT1A
Gene Name		nuclear receptor subfamily 4, group A, member 1	carnitine palmitoyltransferase 1A (liver)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Carnitine O-palmitoyltransferase Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Intracellular Receptor Signaling Pathway Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Long-chain Fatty Acid Metabolic Process Glucose Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Circadian Rhythm Carnitine Metabolic Process Response To Organic Cyclic Compound Epithelial Cell Differentiation Positive Regulation Of Fatty Acid Beta-oxidation Response To Drug Eating Behavior Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Fatty Acid
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Nuclear Receptor transcription pathway Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Generic Transcription Pathway PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) RORA activates circadian gene expression
Drugs			L-Carnitine Perhexiline
Diseases
GWAS			Lipid metabolism phenotypes ( 22286219) Obesity-related traits ( 23251661)
Protein-Protein Interactions		83 interactors: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579	7 interactors: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1
Entrez ID		3164	1374
HPRD ID		00744	02755
Ensembl ID		ENSG00000123358	ENSG00000110090
Uniprot IDs		F5GXF0 P22736	B2RAQ8 P50416 Q8WZ48
PDB IDs		2QW4 3V3E 3V3Q	2LE3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Death Death Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stimulus Intracellular Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Regulation Of Cell Death Signal Transduction Regulation Of Apoptotic Process Regulation Of Signaling Signaling Cellular Response To Stimulus Regulation Of Signal Transduction Cell Communication Apoptotic Signaling Pathway Response To Stress RNA Biosynthetic Process Regulation Of Intracellular Transport Epithelium Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Intracellular Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Placenta Development Reproductive Structure Development Regulation Of Metabolic Process Reproductive System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Toll-like Receptor TLR6:TLR2 Signaling Pathway	Cellular Response To Glucose Starvation Regulation Of Mitochondrial Membrane Potential Response To Gamma Radiation Neural Nucleus Development Positive Regulation Of Endothelial Cell Proliferation Response To Nutrient Levels Response To Extracellular Stimulus Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Endothelial Cell Proliferation Renal System Process Negative Regulation Of Cellular PH Reduction Smooth Muscle Hypertrophy CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Body Fluid Levels Reactive Oxygen Species Metabolic Process Regulation Of Ion Transport Response To Stress Positive Regulation Of Cell Growth Metencephalon Development Cell Activation Response To External Stimulus Response To Wounding Cerebellum Structural Organization Response To Cytokine Cellular Response To Starvation Cellular Response To Organic Substance Response To Ionizing Radiation Positive Regulation Of Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Regulation Of Ion Homeostasis Innate Immune Response Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Neuron Maturation Regulation Of Renal Output By Angiotensin Positive Regulation Of Cell Proliferation Hindbrain Development Response To Toxic Substance Cellular Response To Nutrient Levels Response To Starvation Response To Organic Cyclic Compound Cochlear Nucleus Development Regulation Of Nitrogen Utilization Regulation Of Calcium Ion Transport Platelet Activation Intracellular Receptor Signaling Pathway Regulation Of Ossification Negative Regulation Of Apoptotic Process
Tagcloud ?		1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma	adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit
Tagcloud (Difference) ?		1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma	adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit
Tagcloud (Intersection) ?