NR4A1 and CPT1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NR4A1	CPT1A
Description		nuclear receptor subfamily 4 group A member 1	carnitine palmitoyltransferase 1A
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Nuclear Speck Nuclear Membrane	Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lipopolysaccharide Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Carnitine O-palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Inflammatory Response Signal Transduction Intracellular Receptor Signaling Pathway Detection Of Lipopolysaccharide Endothelial Cell Chemotaxis Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Macrophage Activation Positive Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Non-canonical Inflammasome Complex Assembly	Response To Hypoxia Long-chain Fatty Acid Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Glucose Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Epithelial Cell Differentiation Response To Nutrient Levels Positive Regulation Of Fatty Acid Beta-oxidation Eating Behavior Response To Alkaloid Positive Regulation Of Innate Immune Response Response To Ethanol Aflatoxin Metabolic Process Regulation Of Fatty Acid Oxidation Regulation Of Insulin Secretion Cellular Response To Fatty Acid Liver Regeneration Response To Tetrachloromethane
Pathways		AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer	PPARA activates gene expression Carnitine shuttle RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			Levocarnitine Glyburide Perhexiline
Diseases			Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS			Apolipoprotein A1 levels ( 32203549) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) HDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 22286219) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Obesity-related traits ( 23251661) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32154731 32203549) Urate levels ( 31578528)
Interacting Genes		86 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579	8 interacting genes: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1 UBC
Entrez ID		3164	1374
HPRD ID		00744	02755
Ensembl ID		ENSG00000123358	ENSG00000110090
Uniprot IDs		F5GXF0 P22736 Q6ZMM6	B2RAQ8 P50416 Q8WZ48
PDB IDs		2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1 8WUY 8Y7L	2LE3
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process TOR Signaling Positive Regulation Of RNA Metabolic Process TORC1 Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Response To Lipid Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Binding Ubiquitin Protein Ligase Binding Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Death Positive Regulation Of Biosynthetic Process Protein-containing Complex Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleoplasm Intrinsic Apoptotic Signaling Pathway Response To Nutrient Levels Identical Protein Binding MRNA Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Metabolic Process Response To Hormone Negative Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Oxygen Levels MRNA Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Primary Metabolic Process	Negative Regulation Of Retinal Cell Programmed Cell Death Ubiquitin Protein Ligase Binding Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Cellular PH Reduction Neural Nucleus Development Cellular Response To Glucose Starvation Protein Heterodimerization Activity Nuclear Membrane Response To Gamma Radiation Mitochondrion Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Protein Folding In Endoplasmic Reticulum Reactive Oxygen Species Metabolic Process CD8-positive, Alpha-beta T Cell Lineage Commitment BAD-BCL-2 Complex Channel Inhibitor Activity Endoplasmic Reticulum Membrane Positive Regulation Of Endothelial Cell Proliferation Cerebellum Structural Organization Negative Regulation Of Calcium Ion Transport Into Cytosol Response To Nutrient Levels Regulation Of Calcium Ion Transmembrane Transport Dendritic Cell Apoptotic Process Cochlear Nucleus Development Protein Ubiquitination Regulation Of Melanocyte Differentiation Response To Hormone Regulation Of Nitrogen Utilization Response To Peptide Regulation Of Retinal Cell Programmed Cell Death Response To Ionizing Radiation Response To Cytokine Positive Regulation Of Melanocyte Differentiation Immune System Development Positive Regulation Of Neuron Maturation Retinal Cell Programmed Cell Death Response To Corticosteroid Cellular Response To L-glutamine Positive Regulation Of Mucus Secretion Regulation Of Renal Output By Angiotensin Regulation Of Endothelial Cell Proliferation Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Cell Growth B Cell Lineage Commitment BH3 Domain Binding Positive Regulation Of Pigment Cell Differentiation Regulation Of Blood Volume By Renin-angiotensin
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