NR4A1 and POLA2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NR4A1	POLA2
Gene Name		nuclear receptor subfamily 4, group A, member 1	polymerase (DNA directed), alpha 2, accessory subunit
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytoplasm
	Molecular Function	DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Intracellular Receptor Signaling Pathway Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Protein Import Into Nucleus, Translocation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Nuclear Receptor transcription pathway Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Generic Transcription Pathway PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs			Dacarbazine
Diseases
GWAS
Protein-Protein Interactions		83 interactors: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579	31 interactors: AKTIP APP ASCC2 ATP5C1 CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 NHP2L1 NR4A1 PARP1 POLA1 PRPF38A RBM23 SETDB1 STK40 ULK2 XPNPEP1
Entrez ID		3164	23649
HPRD ID		00744	10160
Ensembl ID		ENSG00000123358
Uniprot IDs		F5GXF0 P22736	Q14181
PDB IDs		2QW4 3V3E 3V3Q	2KEB 4E2I
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Death Death Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stimulus Intracellular Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Regulation Of Cell Death Signal Transduction Regulation Of Apoptotic Process Regulation Of Signaling Signaling Cellular Response To Stimulus Regulation Of Signal Transduction Cell Communication Apoptotic Signaling Pathway Response To Stress RNA Biosynthetic Process Regulation Of Intracellular Transport Epithelium Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Intracellular Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Placenta Development Reproductive Structure Development Regulation Of Metabolic Process Reproductive System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Toll-like Receptor TLR6:TLR2 Signaling Pathway	RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Developmental Growth Growth MRNA Metabolic Process DNA Replication, Synthesis Of RNA Primer Regulation Of Growth Cellular Response To Reactive Oxygen Species Regulation Of Binding Regulation Of Receptor Activity Organ Development Metabolic Process RNA Processing Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Positive Regulation Of Cell Death Histone H3-K9 Modification Negative Regulation Of Epithelial Cell Differentiation Cellular Protein Modification Process Cellular Protein Metabolic Process Chromosome Organization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Hepatocyte Differentiation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Hsp90 Deacetylation Response To Oxidative Stress MRNA Processing RNA Biosynthetic Process Cochlea Development Response To Reactive Oxygen Species Negative Regulation Of Cell Differentiation Cellular Response To Oxidative Stress Lung Alveolus Development Macroautophagy Regulation Of Cell Differentiation System Development Cellular Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport
Tagcloud ?		1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma	beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?		1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma	beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?