NR4A1 and AKT1

Number of citations of the paper that reports this interaction (PMID 11274386)
25

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)
HPRD (in vivo, in vitro)

		NR4A1	AKT1
Gene Name		nuclear receptor subfamily 4, group A, member 1	v-akt murine thymoma viral oncogene homolog 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Plasma Membrane Cell-cell Junction Microtubule Cytoskeleton Ciliary Basal Body
	Molecular Function	DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Enzyme Binding Nitric-oxide Synthase Regulator Activity Identical Protein Binding Phosphatidylinositol-3,4-bisphosphate Binding 14-3-3 Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Intracellular Receptor Signaling Pathway Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Protein Import Into Nucleus, Translocation Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Translation Regulation Of Translation Cellular Protein Modification Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Germ Cell Development Aging Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Apoptotic Mitochondrial Changes Response To Heat Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Endopeptidase Activity Regulation Of Neuron Projection Development Glucose Transport Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Cell Projection Organization Cell Differentiation Protein Catabolic Process Platelet Activation Hyaluronan Metabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration Endocrine Pancreas Development T Cell Costimulation Regulation Of Myelination Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Fatty Acid Beta-oxidation Response To Food Positive Regulation Of Cellular Protein Metabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Cell Size Negative Regulation Of Proteolysis Positive Regulation Of Vasoconstriction Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitric Oxide Metabolic Process Positive Regulation Of Glucose Import Negative Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Striated Muscle Cell Differentiation Mammary Gland Epithelial Cell Differentiation Glycogen Cell Differentiation Involved In Embryonic Placenta Development Labyrinthine Layer Blood Vessel Development Membrane Organization Response To UV-A Cellular Response To Mechanical Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Neuron Death Regulation Of Cell Cycle Checkpoint Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Nuclear Receptor transcription pathway Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Generic Transcription Pathway PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins Signaling by Wnt Platelet Aggregation (Plug Formation) Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade RNF mutants show enhanced WNT signaling and proliferation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions Regulation of mRNA stability by proteins that bind AU-rich elements GAB1 signalosome misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling Translocation of GLUT4 to the plasma membrane deactivation of the beta-catenin transactivating complex VEGFA-VEGFR2 Pathway Metabolism of nitric oxide G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN eNOS activation and regulation Intrinsic Pathway for Apoptosis Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signalling by NGF CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR eNOS activation TCF dependent signaling in response to WNT KSRP destabilizes mRNA GPVI-mediated activation cascade Signaling by WNT in cancer
Drugs			Adenosine triphosphate Arsenic trioxide Inositol 1,3,4,5-Tetrakisphosphate N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
Diseases
GWAS
Protein-Protein Interactions		83 interactors: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579	191 interactors: ACAP1 AHNAK AKT1S1 AKT2 AKTIP ALYREF APLP2 APOH APP APPL1 AR ARFIP2 ARHGAP29 ARHGAP32 ATXN1 BAD BCL10 BCL2L1 BCL2L11 BPGM BRAF BRCA1 CAMKK1 CARHSP1 CASP3 CASP9 CCDC88A CDKN1A CDKN1B CDKN1C CHEK1 CHN2 CHUK CLIP3 CLK2 CREB1 CREBBP CSNK2A1 CTNNB1 CYLD DAB2IP DCTN1 DLC1 DNAJB1 DNMT1 EEF1G EIF4EBP1 EP300 ESR1 ESR2 EZH2 FANCA FOXO1 FOXO3 FOXO4 GAB2 GATA1 GATA2 GRB10 GSK3A GSK3B HIST2H2BE HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB ILK IMPDH2 IRAK1 IRS1 ITGB3 ITPR1 ITPR3 JADE1 KAT2B KAT6A KRT10 KTN1 LRRK2 MAP2K4 MAP3K11 MAP3K5 MAP3K8 MAPK14 MAPK8IP1 MAPKAPK2 MAPT MDM2 MDM4 METTL1 MS4A2 MST1R MTCP1 MTOR MUL1 MXD1 NCOA4 NCOR2 NF2 NOS3 NOTCH1 NR4A1 PAK1 PAK6 PDE3B PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PHB2 PI4K2B PIAS1 PIAS2 PIK3R1 PKN2 PLCG1 PLEKHO1 PLXNA1 PPARGC1B PPL PPM1A PPP1CA PPP2CA PPP2R1A PPP2R4 PRG2 PRKCQ PRKCZ PRKDC PTEN PTPN1 RAB3D RAC1 RAF1 RARA RGCC RHEBL1 RICTOR RNF11 RNF115 RPS6KB1 RQCD1 S1PR1 SETDB1 SH2B2 SH3RF1 SIRT1 SIRT6 SKI SKP2 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SORBS2 SORBS3 SRC STAT1 STK3 STK4 TBC1D4 TCL1A TCL1B TCL6 TERF2IP TERT THEM4 TNFSF11 TOPBP1 TRIB3 TSC1 TSC2 TTC3 USP4 UXS1 VEGFA VIM WNK1 WNK4 XIAP YAP1 YBX1 YWHAZ ZFP36L1 ZHX1
Entrez ID		3164	207
HPRD ID		00744	01261
Ensembl ID		ENSG00000123358	ENSG00000142208
Uniprot IDs		F5GXF0 P22736	B0LPE5 B3KVH4 P31749
PDB IDs		2QW4 3V3E 3V3Q	1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Death Death Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stimulus Intracellular Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Regulation Of Cell Death Signal Transduction Regulation Of Apoptotic Process Regulation Of Signaling Signaling Cellular Response To Stimulus Regulation Of Signal Transduction Cell Communication Apoptotic Signaling Pathway Response To Stress RNA Biosynthetic Process Regulation Of Intracellular Transport Epithelium Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Intracellular Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Placenta Development Reproductive Structure Development Regulation Of Metabolic Process Reproductive System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Toll-like Receptor TLR6:TLR2 Signaling Pathway	Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Cellular Response To Organic Substance Response To Organic Substance Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Death Death Response To Stimulus Programmed Cell Death Apoptotic Process Regulation Of Catalytic Activity Signal Transduction Signaling Cellular Response To Growth Factor Stimulus Cell Communication Regulation Of Kinase Activity Response To Growth Factor Response To Stress Negative Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Cell Proliferation Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune System Process Regulation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Immune System Process Positive Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma	advance catenin contributes decreasing deregulation doi dramatically foxo1 glioma gliomas implicate inducing insights introduction invasion january micrornas mir mirnas onc oncogene online phosphorylated publication silencing suppressed tissues tumorigenesis unfavorable
Tagcloud (Difference) ?		1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma	advance catenin contributes decreasing deregulation doi dramatically foxo1 glioma gliomas implicate inducing insights introduction invasion january micrornas mir mirnas onc oncogene online phosphorylated publication silencing suppressed tissues tumorigenesis unfavorable
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