SCGB1A1 and LRP2

Number of citations of the paper that reports this interaction (PubMedID 11278724)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SCGB1A1	LRP2
Description		secretoglobin family 1A member 1	LDL receptor related protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Envelope Cytoplasm Secretory Granule Extracellular Exosome	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Brush Border Clathrin-coated Pit External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Cell Projection Receptor Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding Phospholipase A2 Inhibitor Activity Polychlorinated Biphenyl Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Female Pregnancy Embryo Implantation Response To Xenobiotic Stimulus Response To Ozone Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Response To Silicon Dioxide Response To Cytokine T Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of MRNA Stability Regulation Of Inflammatory Response Response To Glucocorticoid Response To Fibroblast Growth Factor	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Nervous System Development Heart Development Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Gene Expression Protein Transport Cobalamin Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Diol Metabolic Process Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Vitamin Transport Vagina Development Coronary Vasculature Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Cranial Skeletal System Development Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways			Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body
Drugs		4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL	Urokinase Insulin human
Diseases			Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		Alanine aminotransferase levels ( 33547301) Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Gamma glutamyl transferase levels ( 29403010) Serum CC16 levels ( 32839289) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 29779033 31451708 31152163 31015462 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 26831199 28452372) Gout ( 33832965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010 29124443) Urate levels ( 20139978 31578528)
Interacting Genes		7 interacting genes: AQP6 CUBN FN1 LMBR1L LRP2 TMEM43 TRIM32	53 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 DYRK1A GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR USP40
Entrez ID		7356	4036
HPRD ID		01884	02509
Ensembl ID		ENSG00000149021	ENSG00000081479
Uniprot IDs		A0A0S2Z4R6 P11684	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		7VF3 7VG7	2M0P
Enriched GO Terms of Interacting Partners?		Cobalamin Transport Cargo Receptor Activity Receptor-mediated Endocytosis Nitrate Transmembrane Transporter Activity Axon Development Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Endoplasmic Reticulum Brush Border Membrane Brush Border Alcohol Metabolic Process Vitamin Transport Steroid Metabolic Process Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Clathrin-coated Pit Endocytic Vesicle PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Apical Plasma Membrane Regulation Of Fibroblast Proliferation Regulation Of Neurogenesis Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Lysosomal Membrane Apical Part Of Cell Extrinsic Component Of External Side Of Plasma Membrane Vesicle Tethering To Endoplasmic Reticulum Protein Localization To Phagocytic Vesicle Positive Regulation Of Cell Development Regulation Of Nervous System Development Endocytosis Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Lipid Metabolic Process Folate Transmembrane Transport Cholesterol Metabolic Process Striated Muscle Myosin Thick Filament Sterol Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Calcium-independent Cell-matrix Adhesion Endoplasmic Reticulum-endosome Membrane Contact Site Actin Modification Regulation Of Cell Shape Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Microtubule Bundle Regulation Of Axonogenesis Positive Regulation Of Lysosomal Protein Catabolic Process	Low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Heparin Binding Regulation Of Cell-substrate Adhesion Very-low-density Lipoprotein Particle Regulation Of Receptor-mediated Endocytosis Amyloid-beta Binding Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Biological Quality Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Vesicle-mediated Transport Protein Kinase Binding Negative Regulation Of Fibrinolysis Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Signal Transduction Chylomicron Regulation Of Cell Migration Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Cell Projection Organization Receptor Ligand Activity Intermediate-density Lipoprotein Particle Regulation Of Endothelial Cell Migration Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Fibrinolysis Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Extracellular Exosome Positive Regulation Of Cell Motility Positive Regulation Of Transport Regulation Of Amyloid-beta Clearance Regulation Of Proteolysis Extracellular Region Regulation Of Transport Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Endosome Lumen Cell Periphery Cell Adhesion Positive Regulation Of Receptor-mediated Endocytosis
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