SCGB1A1 and CUBN

Number of citations of the paper that reports this interaction (PMID 11278724)
9

Data Source:
HPRD (in vivo)

		SCGB1A1	CUBN
Gene Name		secretoglobin, family 1A, member 1 (uteroglobin)	cubilin (intrinsic factor-cobalamin receptor)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Rough Endoplasmic Reticulum Secretory Granule Extracellular Vesicular Exosome	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Coated Pit Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Brush Border Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phospholipase A2 Inhibitor Activity	Receptor Activity Transporter Activity Calcium Ion Binding Protein Binding Cobalamin Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Female Pregnancy Embryo Implantation Response To Xenobiotic Stimulus Response To Ozone Response To Lipopolysaccharide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Response To Silicon Dioxide Response To Cytokine Negative Regulation Of T Cell Proliferation Response To Drug Negative Regulation Of Catalytic Activity Regulation Of MRNA Stability Regulation Of Inflammatory Response Response To Glucocorticoid Response To Fibroblast Growth Factor	Tissue Homeostasis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cobalamin Metabolic Process Cobalamin Transport Lipoprotein Metabolic Process Vitamin D Metabolic Process Lipoprotein Transport Small Molecule Metabolic Process
Pathways			Lipoprotein metabolism Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Lipid digestion, mobilization, and transport Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Metabolism of steroid hormones and vitamin D Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism HDL-mediated lipid transport Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Vitamin D (calciferol) metabolism Defects in vitamin and cofactor metabolism
Drugs			Hydroxocobalamin
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326)	Folate pathway vitamin levels ( 19303062 19744961) MRI atrophy measures ( 21116278) Quantitative traits ( 19197348) Urinary albumin excretion ( 21355061)
Protein-Protein Interactions		5 interactors: CUBN FN1 LMBR1L LRP2 TRIM32	9 interactors: ALB BRCA1 CBL GC GIF LGALS3 LRP2 SCGB1A1 TF
Entrez ID		7356	8029
HPRD ID		01884	04296
Ensembl ID		ENSG00000149021	ENSG00000107611
Uniprot IDs		P11684	O60494
PDB IDs			3KQ4
Enriched GO Terms of Interacting Partners?		Vitamin D Metabolic Process Vesicle-mediated Transport Endocytosis Vitamin Metabolic Process Positive Regulation Of Cell Growth Calcium-independent Cell-matrix Adhesion Positive Regulation Of Growth Steroid Metabolic Process Cobalamin Transport Positive Regulation Of Proteolysis Positive Regulation Of Neuron Differentiation Response To Light Stimulus Alcohol Metabolic Process Regulation Of Cell Growth Receptor-mediated Endocytosis Integrin Activation Positive Regulation Of Neurogenesis Negative Regulation Of Viral Release From Host Cell Response To Radiation Cobalamin Metabolic Process Lipoprotein Transport Positive Regulation Of Cell Development Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of Neuron Differentiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Vitamin Metabolic Process Vitamin D Metabolic Process Steroid Metabolic Process Vitamin Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Retina Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Platelet Degranulation Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Histone H4-K16 Acetylation Blood Coagulation Hemostasis Negative Regulation Of Signal Transduction Response To Stress Negative Regulation Of T Cell Activation Response To Steroid Hormone Negative Regulation Of Signaling Negative Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Tumor Necrosis Factor Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Histone H3-K9 Acetylation Glucosylceramide Catabolic Process Maintenance Of Mitochondrion Location Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Small Molecule Metabolic Process Lipid Metabolic Process Regulation Of Cytokine Production Response To Tumor Necrosis Factor Regulation Of Body Fluid Levels Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Mononuclear Cell Migration Response To Silicon Dioxide Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Response To Organic Substance Wound Healing Response To Stimulus Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Mononuclear Cell Migration Response To Glucocorticoid Negative Regulation Of Leukocyte Activation
Tagcloud ?		bmp4 branching catenin cc10 coactivator determination disrupted distal embryonic epicardial epithelium ex fgf10 genetically hallmarks histology iq1 lung lungs morphogenesis pharmacologically proximal proximalized proximalizes reinitiated reversible sox2 usage utero	accordingly advocate amn amnionless b12 coexpressed coreceptor correct critically cubilin endocytosis extremely glomerular ileum interdependency internalization lacks localize lrp2 malabsorption megalin mutually proteinuria suffer surprisingly transmembrane tubules ultrafiltrate vitamin
Tagcloud (Difference) ?		bmp4 branching catenin cc10 coactivator determination disrupted distal embryonic epicardial epithelium ex fgf10 genetically hallmarks histology iq1 lung lungs morphogenesis pharmacologically proximal proximalized proximalizes reinitiated reversible sox2 usage utero	accordingly advocate amn amnionless b12 coexpressed coreceptor correct critically cubilin endocytosis extremely glomerular ileum interdependency internalization lacks localize lrp2 malabsorption megalin mutually proteinuria suffer surprisingly transmembrane tubules ultrafiltrate vitamin
Tagcloud (Intersection) ?