SCGB1A1 and CUBN

Number of citations: 0 (PubMedID 11278724)
Data Source: HPRD (in vivo)

		SCGB1A1	CUBN
Name		secretoglobin family 1A member 1	cubilin
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Envelope Cytoplasm Secretory Granule Extracellular Exosome	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Brush Border Clathrin-coated Pit Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Cell Projection Membrane Brush Border Membrane Microvillus Membrane Lysosomal Lumen Receptor Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding Phospholipase A2 Inhibitor Activity Polychlorinated Biphenyl Binding	Calcium Ion Binding Protein Binding Cobalamin Binding Signaling Receptor Activity Cargo Receptor Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Female Pregnancy Embryo Implantation Response To Xenobiotic Stimulus Response To Ozone Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Response To Silicon Dioxide Response To Cytokine T Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of MRNA Stability Regulation Of Inflammatory Response Response To Glucocorticoid Response To Fibroblast Growth Factor	Tissue Homeostasis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cobalamin Metabolic Process Response To Bacterium Protein Transport Cobalamin Transport Lipoprotein Transport Establishment Of Localization In Cell
Pathways		None	Vitamin D (calciferol) metabolism Defective AMN causes MGA1 Defective CUBN causes MGA1 HDL clearance Uptake of dietary cobalamins into enterocytes
Drugs		4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL	Hydroxocobalamin
GWAS		Alanine aminotransferase levels ( 33547301 ) Body size at age 10 ( 32376654 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) Gamma glutamyl transferase levels ( 29403010 ) Serum CC16 levels ( 32839289 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Binge eating behaviour in bipolar disorder ( 29391396 ) Bipolar disorder (early vs late onset) ( 34016946 ) Cholesterol, total ( 24097068 ) Colorectal cancer ( 25990418 ) Folate pathway vitamin levels ( 19744961 19303062 ) High density lipoprotein cholesterol levels ( 30498476 ) Homocysteine levels ( 23824729 ) Metabolite levels ( 23823483 ) Microalbuminuria ( 26631737 31511532 ) Molybdenum levels ( 26025379 ) Platelet distribution width ( 27863252 ) Plateletcrit ( 32888494 ) Proteinuria ( 30476138 ) Proteinuria (mild) ( 30476138 ) Proteinuria (moderate to severe) ( 30476138 ) Quantitative traits ( 19197348 ) Superior temporal gyrus volume ( 31530798 ) Total cholesterol levels ( 28334899 ) Total grey matter volume ( 31530798 ) Urate levels ( 31578528 ) Urinary albumin excretion ( 30220432 21355061 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 27650483 31511532 26631737 31630189 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 ) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737 ) Vitamin B levels in ischemic stroke ( 25147783 ) Whole-brain volume ( 21116278 )
Novel Interactors		2 novel interactors: MARK2 STARD3	None recorded
Interacting Genes		7 interacting genes: AQP6 CUBN FN1 LMBR1L LRP2 TMEM43 TRIM32	9 interacting genes: ALB BRCA1 CBL CBLIF GC LGALS3 LRP2 SCGB1A1 TF
Entrez ID		7356	8029
HPRD ID		01884	04296
Ensembl ID		ENSG00000149021	ENSG00000107611
Uniprot IDs		A0A0S2Z4R6 P11684	O60494
PDB IDs		7VF3 7VG7	3KQ4 6GJE
GO Terms Enriched among Interactors		Cobalamin Transport Cargo Receptor Activity Receptor-mediated Endocytosis Nitrate Transmembrane Transporter Activity Axon Development Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Endoplasmic Reticulum Brush Border Membrane Brush Border Alcohol Metabolic Process Vitamin Transport Steroid Metabolic Process Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Clathrin-coated Pit Endocytic Vesicle PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Apical Plasma Membrane Regulation Of Fibroblast Proliferation Regulation Of Neurogenesis Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Lysosomal Membrane Apical Part Of Cell Extrinsic Component Of External Side Of Plasma Membrane Vesicle Tethering To Endoplasmic Reticulum Protein Localization To Phagocytic Vesicle Positive Regulation Of Cell Development Regulation Of Nervous System Development Endocytosis Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Lipid Metabolic Process Folate Transmembrane Transport Cholesterol Metabolic Process Striated Muscle Myosin Thick Filament Sterol Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Calcium-independent Cell-matrix Adhesion Endoplasmic Reticulum-endosome Membrane Contact Site Actin Modification Regulation Of Cell Shape Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Microtubule Bundle Regulation Of Axonogenesis Positive Regulation Of Lysosomal Protein Catabolic Process	Vitamin Transport Cobalamin Transport Blood Microparticle Extracellular Space Vitamin D Metabolic Process Vitamin Transmembrane Transport Extracellular Region Extracellular Exosome Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Programmed Cell Death Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Process Protein Autoubiquitination BRCA1-BARD1 Complex Positive Regulation Of Receptor-mediated Endocytosis Response To Growth Factor Regulation Of Endocytosis Calcidiol Binding Lysosomal Lumen Apical Plasma Membrane Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Folate Import Across Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Clathrin-coated Pit Endocytic Vesicle Polychlorinated Biphenyl Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding SH3 Domain Binding Male Gonad Development Cargo Receptor Ligand Activity Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Folate Transmembrane Transport Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Response To Nutrient Levels Regulation Of Receptor-mediated Endocytosis Transmembrane Transport Response To Stress BRCA1-B Complex Regulation Of Rap Protein Signal Transduction Response To Ozone Response To Silicon Dioxide