SCGB1A1 and MARK2

		SCGB1A1	MARK2
Description		secretoglobin family 1A member 1	microtubule affinity regulating kinase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Envelope Cytoplasm Secretory Granule Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle
	Molecular Function	Protein Binding Phospholipase A2 Inhibitor Activity Polychlorinated Biphenyl Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Female Pregnancy Embryo Implantation Response To Xenobiotic Stimulus Response To Ozone Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Response To Silicon Dioxide Response To Cytokine T Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of MRNA Stability Regulation Of Inflammatory Response Response To Glucocorticoid Response To Fibroblast Growth Factor	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly
Pathways
Drugs		4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL	Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Gamma glutamyl transferase levels ( 29403010) Serum CC16 levels ( 32839289) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		7 interacting genes: AQP6 CUBN FN1 LMBR1L LRP2 TMEM43 TRIM32	31 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L PAK5 PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 YWHAB YWHAZ
Entrez ID		7356	2011
HPRD ID		01884	02753
Ensembl ID		ENSG00000149021	ENSG00000072518
Uniprot IDs		A0A0S2Z4R6 P11684	A0A140VJP1 A8K2S4 Q7KZI7
PDB IDs		7VF3 7VG7	3IEC 5EAK 5KZ7 5KZ8 8TXY
Enriched GO Terms of Interacting Partners?		Cobalamin Transport Cargo Receptor Activity Receptor-mediated Endocytosis Nitrate Transmembrane Transporter Activity Axon Development Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Endoplasmic Reticulum Brush Border Membrane Brush Border Alcohol Metabolic Process Vitamin Transport Steroid Metabolic Process Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Clathrin-coated Pit Endocytic Vesicle PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Apical Plasma Membrane Regulation Of Fibroblast Proliferation Regulation Of Neurogenesis Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Lysosomal Membrane Apical Part Of Cell Extrinsic Component Of External Side Of Plasma Membrane Vesicle Tethering To Endoplasmic Reticulum Protein Localization To Phagocytic Vesicle Positive Regulation Of Cell Development Regulation Of Nervous System Development Endocytosis Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Lipid Metabolic Process Folate Transmembrane Transport Cholesterol Metabolic Process Striated Muscle Myosin Thick Filament Sterol Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Calcium-independent Cell-matrix Adhesion Endoplasmic Reticulum-endosome Membrane Contact Site Actin Modification Regulation Of Cell Shape Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Microtubule Bundle Regulation Of Axonogenesis Positive Regulation Of Lysosomal Protein Catabolic Process	Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding
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