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UBE2D1 and UBE3A
Number of citations of the paper that reports this interaction (PubMedID
23542176
)
72
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
UBE2D1
UBE3A
Description
ubiquitin conjugating enzyme E2 D1
ubiquitin protein ligase E3A
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Proteasome Complex
Nucleus
Cytoplasm
Cytosol
Synaptic Vesicle
Glutamatergic Synapse
Postsynaptic Cytosol
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Positive Regulation Of Protein Polyubiquitination
Negative Regulation Of TORC1 Signaling
Protein Polyubiquitination
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Macromolecule Metabolic Process
Protein Ubiquitination
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
Response To Progesterone
Sperm Entry
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Rhythmic Process
Animal Organ Development
System Development
Modulation Of Chemical Synaptic Transmission
Progesterone Receptor Signaling Pathway
Protein Autoubiquitination
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Prostate Gland Growth
Protein K48-linked Ubiquitination
Regulation Of Primary Metabolic Process
Positive Regulation Of Protein Localization To Lysosome
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Golgi Lumen Acidification
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
TICAM1, RIP1-mediated IKK complex recruitment
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
Regulation of TNFR1 signaling
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Cardiac hypertrophy (
21348951
)
Gene methylation in lung tissue (
25713168
)
Obesity-related traits (
23251661
)
Interacting Genes
239 interacting genes:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ARK2C
ARRDC3
ASB2
ASB4
ASB9
BABAM2
BARD1
BFAR
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
COP1
CRBN
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
CUL4A
DTL
DTX1
DTX2
DTX3
DTX3L
DYRK2
DZIP3
EP300
EPS15
F12
FAF2
FBXL2
FBXL20
FBXO2
FBXO7
FOS
FZR1
GADD45A
GSK3B
HDAC6
HECTD1
HECW1
HERC2
HERC3
HIF1A
HSD17B10
HUWE1
ITCH
KAT2B
KCTD17
KDM2B
KEAP1
KLHL13
KLHL2
KLHL9
LNPK
LRR1
LRSAM1
LTN1
MAP3K1
MARCHF1
MARCHF2
MARCHF4
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEOX2
MGRN1
MIB1
MIB2
MID1
MID2
MKNK1
MKRN1
MKRN2
MKRN3
MUL1
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NQO1
NR1H2
OBI1
PELI1
PJA2
PMAIP1
POLL
POLM
POLR2E
PRKN
RABGEF1
RAG1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF13
RNF130
RNF14
RNF144A
RNF150
RNF166
RNF167
RNF168
RNF181
RNF182
RNF185
RNF2
RNF207
RNF216
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
SH3RF1
SHPRH
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF1
SPOP
STAM2
STUB1
TAF1D
TBL1X
TMEM129
TNFAIP3
TNNT1
TOM1
TOPORS
TRAF2
TRAF4
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM21
TRIM22
TRIM23
TRIM24
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM69
TRIM7
TRIM72
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UBR5
UBTD1
UFM1
UHRF1
UHRF2
USP21
UVSSA
VHL
WWP1
WWP2
XIAP
ZNF598
ZNRF1
ZNRF2
ZNRF4
ZRANB1
165 interacting genes:
ACTA2
ACTB
ACTBL2
ACTR3
ADRM1
AFG3L1P
AFTPH
AHSP
ALDH1A2
ANXA1
APP
AR
ARC
ARHGDIB
ASAP3
ATG9A
BAK1
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
CALR
CAPN3
CDK1
CDK4
CDKN1B
CEBPZ
CGGBP1
CKB
CRP
CSTPP1
CTNNB1
DAZAP2
DDI2
DLG1
DLG4
E2F1
EAPP
EEF1A2
EID1
EIF4G1
EML1
ENO1
ENO2
ESR1
FAF2
GFAP
GOPC
GTF3C1
HBA1
HPCAL4
HSP90AB1
HSPA2
HSPA4
HSPA5
IL24
JADE1
KLHL38
KRT1
KRT5
KRT7
KRT9
LCK
LCN2
MAGEA12
MAGEA8
MAPK1
MAPK10
MARF1
MCM2
MCM4
MCM6
MCM7
MDM1
MDM2
MDM4
MEOX2
MSTO1
MYCBP
MYCN
NBPF14
NDUFA13
NELFCD
NFX1
NHERF1
NOMO2
NR3C1
NR4A3
NUMBL
PAICS
PARVA
PAX5
PAX6
PBRM1
PDE1B
PDIA3
PDIA6
PGK1
PGR
PKM
PML
POLE4
PPIA
PPP1R3F
PRAG1
PRDX1
PRKACA
PRMT5
PRSS1
PSAP
PTCD3
RAD23A
RAD23B
RARA
RMI1
RNF152
RNF2
RPS15A
RYBP
SACS
SCAMP1
SCRIB
SERPINB2
SET
SHBG
SIPA1L1
SIRT6
SMAD9
SNAPC3
SOD1
SPINK1
SUMO3
TALDO1
TAT
TBC1D14
TCF19
TMEM14B
TP53
TP53BP2
TRIM65
TSC2
TTC23L
TTC3
TUBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBQLN2
UBR5
WBP2
WDR4
YOD1
YWHAE
YWHAG
ZNF250
ZNF446
Entrez ID
7321
7337
HPRD ID
04267
03375
Ensembl ID
ENSG00000072401
ENSG00000114062
Uniprot IDs
A0A087WW00
P51668
A0A6Q8PHE5
Q05086
Q9H2G0
PDB IDs
2C4P
2YHO
3OJ4
3PTF
4AP4
4QPL
5FER
5TUT
6D4P
7ZJ3
1C4Z
1D5F
1EQX
2KR1
4GIZ
4XR8
6SJV
6SLM
6TGK
6U19
7Q41
7QPB
8ENP
8EPT
8GCR
8JRN
8JRO
8JRP
8JRQ
8JRR
8R1F
8R1G
9CHT
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Polyubiquitination
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Transferase Activity
Macromolecule Catabolic Process
Zinc Ion Binding
Macromolecule Metabolic Process
Proteolysis
Catabolic Process
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Metal Ion Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K63-linked Ubiquitination
Cytoplasm
Protein Monoubiquitination
Response To Stress
Ubiquitin Ligase Complex
Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Post-translational Protein Modification
Cytosol
Immune System Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Ubiquitination
Canonical NF-kappaB Signal Transduction
DNA Damage Response
Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Binding
Cytosol
Nucleus
Cytoplasm
Ubiquitin Protein Ligase Binding
Cellular Response To Stress
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Protein Polyubiquitination
Ubiquitin-protein Transferase Activity
Nucleoplasm
Regulation Of Cell Cycle
Regulation Of Macromolecule Metabolic Process
Response To Stress
Protein-containing Complex
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Mitotic Cell Cycle
Extracellular Exosome
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Nuclear Receptor-mediated Signaling Pathway
Protein Metabolic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Post-translational Protein Modification
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Protein Binding
Protein Modification By Small Protein Conjugation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Programmed Cell Death
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Ubiquitination
Positive Regulation Of Biosynthetic Process
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Macromolecule Metabolic Process
Macromolecule Catabolic Process
Enzyme Binding
Identical Protein Binding
Regulation Of DNA-templated Transcription
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