UBE2D1 and UHRF1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (pull down, affinity chromatography technology, pull down)

		UBE2D1	UHRF1
Name		ubiquitin conjugating enzyme E2 D1	ubiquitin like with PHD and ring finger domains 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Spindle Nuclear Matrix
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Transferase Activity Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K9me2/3 Reader Activity DNA Damage Sensor Activity Histone H3 Ubiquitin Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Negative Regulation Of TORC1 Signaling	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Response To Stress DNA Damage Response Protein Ubiquitination Heterochromatin Formation Homologous Recombination Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Protein Autoubiquitination Mitotic Spindle Assembly
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex TICAM1, RIP1-mediated IKK complex recruitment APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Signaling by BMP Downstream TCR signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Ovarian tumor domain proteases Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Aberrant regulation of mitotic exit in cancer due to RB1 defects Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	DNA methylation Chromatin modifications during the maternal to zygotic transition (MZT)
GWAS		Brain imaging ( 20100581 ) Crohn's disease ( 21102463 )	Age at first sexual intercourse ( 34211149 ) Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 ) Hip circumference adjusted for BMI ( 34021172 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Mental health study participation (completed survey) ( 31263887 ) Systolic blood pressure ( 30578418 ) Type 2 diabetes ( 30297969 ) Urate levels ( 31578528 )
Interacting Genes		239 interacting genes: AMFR ANAPC11 ANXA1 ANXA7 AREL1 ARIH1 ARIH2 ARK2C ARRDC3 ASB2 ASB4 ASB9 BABAM2 BARD1 BFAR BIRC2 BIRC3 BIRC6 BIRC7 BIRC8 BRCA1 BRCC3 BRMS1 C7orf25 CADPS2 CBL CBLC CDK7 CDKN1A CHFR CNOT4 COP1 CRBN CREBBP CRYAB CTNNB1 CUL2 CUL3 CUL4A DTL DTX1 DTX2 DTX3 DTX3L DYRK2 DZIP3 EP300 EPS15 F12 FAF2 FBXL2 FBXL20 FBXO2 FBXO7 FOS FZR1 GADD45A GSK3B HDAC6 HECTD1 HECW1 HERC2 HERC3 HIF1A HSD17B10 HUWE1 ITCH KAT2B KCTD17 KDM2B KEAP1 KLHL13 KLHL2 KLHL9 LNPK LRR1 LRSAM1 LTN1 MAP3K1 MARCHF1 MARCHF2 MARCHF4 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEOX2 MGRN1 MIB1 MIB2 MID1 MID2 MKNK1 MKRN1 MKRN2 MKRN3 MUL1 NBN NEDD4 NEDD4L NEURL1 NFKBIA NHLRC1 NQO1 NR1H2 OBI1 PELI1 PJA2 PMAIP1 POLL POLM POLR2E PRKN RABGEF1 RAG1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF125 RNF126 RNF13 RNF130 RNF14 RNF144A RNF150 RNF166 RNF167 RNF168 RNF181 RNF182 RNF185 RNF2 RNF207 RNF216 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF43 RNF5 RNF6 RNF7 RNF8 SH3RF1 SHPRH SIAH1 SIAH2 SIRT6 SIVA1 SKP1 SMURF1 SPOP STAM2 STUB1 TAF1D TBL1X TMEM129 TNFAIP3 TNNT1 TOM1 TOPORS TRAF2 TRAF4 TRAF6 TRAF7 TRAIP TRIM10 TRIM17 TRIM21 TRIM22 TRIM23 TRIM24 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM35 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM69 TRIM7 TRIM72 TRIM8 TRIP12 TSC22D1 UBA1 UBA6 UBASH3B UBC UBE3A UBE3C UBE4A UBOX5 UBR5 UBTD1 UFM1 UHRF1 UHRF2 USP21 UVSSA VHL WWP1 WWP2 XIAP ZNF598 ZNRF1 ZNRF2 ZNRF4 ZRANB1	36 interacting genes: AKT1 ATR DNMT3A ERCC1 ERG FANCD2 FZR1 H2AC4 H2BC3 H3-3A H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 KIF11 LASP1 LIG1 MBD4 MUS81 NR3C1 PCLAF PCNA PLK1 PRKACA SAP30 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UHRF2 USP7
Entrez ID		7321	29128
HPRD ID		04267	06992
Ensembl ID		ENSG00000072401	ENSG00000276043
Uniprot IDs		A0A087WW00 P51668	A0A087WVR3 Q96T88
PDB IDs		2C4P 2YHO 3OJ4 3PTF 4AP4 4QPL 5FER 5TUT 6D4P 7ZJ3	2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED 6VYJ 6W92 7FB7 8JIG 8WMS 8XV4 8XV6 8XV7 8XV8
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Macromolecule Catabolic Process Zinc Ion Binding Macromolecule Metabolic Process Proteolysis Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Metal Ion Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Cytoplasm Protein Monoubiquitination Response To Stress Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction DNA Damage Response Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding	Nucleoplasm Nucleus DNA Repair Nucleosome Chromosome Structural Constituent Of Chromatin Chromatin Organization Chromatin Remodeling DNA Metabolic Process DNA Damage Response DNA Binding Nucleosome Assembly Nucleosome Organization Cellular Response To Stress Chromosome Organization Protein Heterodimerization Activity Chromosome, Telomeric Region Protein-DNA Complex Assembly Macromolecule Metabolic Process Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process TORC1 Signaling Response To Radiation Negative Regulation Of TORC1 Signaling Protein-containing Complex Mitotic DNA Damage Checkpoint Signaling Protein Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Mitotic DNA Integrity Checkpoint Signaling Chromatin Binding Response To Ionizing Radiation Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ubiquitin Conjugating Enzyme Activity Response To UV TOR Signaling Cellular Response To Nutrient Levels Regulation Of Cell Cycle Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Stress Negative Regulation Of TOR Signaling