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UBE2D1 and RABGEF1
Number of citations of the paper that reports this interaction (PubMedID
17341663
)
56
Data Source:
BioGRID
(pull down)
UBE2D1
RABGEF1
Description
ubiquitin conjugating enzyme E2 D1
RAB guanine nucleotide exchange factor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Nucleolus
Cytoplasm
Endosome
Early Endosome
Cytosol
Endocytic Vesicle
Dendrite
Early Endosome Membrane
Vesicle
Recycling Endosome
Presynaptic Endosome
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
DNA Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Zinc Ion Binding
Small GTPase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Positive Regulation Of Protein Polyubiquitination
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Leukocyte Migration
Protein Targeting To Membrane
Endocytosis
Receptor-mediated Endocytosis
Ras Protein Signal Transduction
Protein Transport
Vesicle-mediated Transport
Endosomal Transport
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Mast Cell Cytokine Production
Negative Regulation Of Mast Cell Activation
Kit Signaling Pathway
Mast Cell Degranulation
Negative Regulation Of Mast Cell Degranulation
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Receptor-mediated Endocytosis
Negative Regulation Of Inflammatory Response
Establishment Of Localization In Cell
Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Mast Cell Migration
Dendritic Transport
Negative Regulation Of Kit Signaling Pathway
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
TICAM1, RIP1-mediated IKK complex recruitment
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
Regulation of TNFR1 signaling
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Aortic root size (
21223598
)
Central corneal thickness (
29760442
32528159
)
Interacting Genes
239 interacting genes:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ARK2C
ARRDC3
ASB2
ASB4
ASB9
BABAM2
BARD1
BFAR
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
COP1
CRBN
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
CUL4A
DTL
DTX1
DTX2
DTX3
DTX3L
DYRK2
DZIP3
EP300
EPS15
F12
FAF2
FBXL2
FBXL20
FBXO2
FBXO7
FOS
FZR1
GADD45A
GSK3B
HDAC6
HECTD1
HECW1
HERC2
HERC3
HIF1A
HSD17B10
HUWE1
ITCH
KAT2B
KCTD17
KDM2B
KEAP1
KLHL13
KLHL2
KLHL9
LNPK
LRR1
LRSAM1
LTN1
MAP3K1
MARCHF1
MARCHF2
MARCHF4
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEOX2
MGRN1
MIB1
MIB2
MID1
MID2
MKNK1
MKRN1
MKRN2
MKRN3
MUL1
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NQO1
NR1H2
OBI1
PELI1
PJA2
PMAIP1
POLL
POLM
POLR2E
PRKN
RABGEF1
RAG1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF13
RNF130
RNF14
RNF144A
RNF150
RNF166
RNF167
RNF168
RNF181
RNF182
RNF185
RNF2
RNF207
RNF216
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
SH3RF1
SHPRH
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF1
SPOP
STAM2
STUB1
TAF1D
TBL1X
TMEM129
TNFAIP3
TNNT1
TOM1
TOPORS
TRAF2
TRAF4
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM21
TRIM22
TRIM23
TRIM24
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM69
TRIM7
TRIM72
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UBR5
UBTD1
UFM1
UHRF1
UHRF2
USP21
UVSSA
VHL
WWP1
WWP2
XIAP
ZNF598
ZNRF1
ZNRF2
ZNRF4
ZRANB1
49 interacting genes:
ABI2
ANKRD29
AP1G1
ARRDC3
BLOC1S6
CCHCR1
CDC37
CIPC
DAZAP2
DCTN2
DGCR6
DNAJC5
EMILIN1
GGA1
GGA2
GPRASP2
HOOK2
HRAS
IHO1
KXD1
MID2
MON1A
MON1B
OIP5
RAB33B
RAB4A
RABEP1
RAD23A
RASAL3
RNF11
RNF168
RPS27A
SESTD1
SNAPIN
SPART
SSX3
TCHP
TEAD4
THOC1
TRIM15
TRIM54
TXN2
UBA52
UBB
UBE2D1
UBE2D3
WASHC1
YWHAB
ZC2HC1C
Entrez ID
7321
27342
HPRD ID
04267
11477
Ensembl ID
ENSG00000072401
ENSG00000154710
Uniprot IDs
A0A087WW00
P51668
A8K3R3
B3KMF1
Q9UJ41
PDB IDs
2C4P
2YHO
3OJ4
3PTF
4AP4
4QPL
5FER
5TUT
6D4P
7ZJ3
1TXU
2C7M
2C7N
2OT3
4N3X
4N3Y
4N3Z
4Q9U
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Polyubiquitination
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Transferase Activity
Macromolecule Catabolic Process
Zinc Ion Binding
Macromolecule Metabolic Process
Proteolysis
Catabolic Process
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Metal Ion Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K63-linked Ubiquitination
Cytoplasm
Protein Monoubiquitination
Response To Stress
Ubiquitin Ligase Complex
Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Post-translational Protein Modification
Cytosol
Immune System Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Ubiquitination
Canonical NF-kappaB Signal Transduction
DNA Damage Response
Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Binding
Establishment Of Protein Localization
Protein Transport
Vesicle-mediated Transport
Intracellular Protein Localization
Protein Binding
Adipose Tissue Development
Protein Tag Activity
BLOC-1 Complex
Establishment Of Localization In Cell
Intracellular Transport
Ubiquitin Protein Ligase Binding
Recycling Endosome
Connective Tissue Development
Endosome
Protein Ubiquitination
Cellular Localization
Ubiquitin Protein Ligase Activity
Mon1-Ccz1 Complex
Vacuolar Transport
Organelle Transport Along Microtubule
Protein Modification By Small Protein Conjugation
Cytoplasm
Vesicle-mediated Transport In Synapse
Melanosome Organization
Vesicle
Endosome Membrane
Post-Golgi Vesicle-mediated Transport
Pigment Granule Organization
Modification-dependent Protein Catabolic Process
Ubiquitin Binding
Protein Localization To Ciliary Membrane
Regulation Of Lysosome Size
BORC Complex
Cytoskeleton-dependent Intracellular Transport
Early Endosome Membrane
Microvesicle
Protein Targeting
Early Endosome
Endosome To Melanosome Transport
Fat Pad Development
Regulation Of Endosome Size
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Cytosol
Post-translational Protein Modification
Vesicle-mediated Transport To The Plasma Membrane
Cytoplasmic Side Of Lysosomal Membrane
Proteolysis Involved In Protein Catabolic Process
Golgi To Plasma Membrane Transport
Intracellular Protein Transport
Secretion By Cell
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Tagcloud (Difference)
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Tagcloud (Intersection)
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