UBE2D1 and NQO1

Number of citations: 49 (PubMedID 27733512)
Data Source: BioGRID (enzymatic study)

		UBE2D1	NQO1
Name		ubiquitin conjugating enzyme E2 D1	NAD(P)H quinone dehydrogenase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Identical Protein Binding NADH Dehydrogenase (quinone) (non-electrogenic) Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Negative Regulation Of TORC1 Signaling	Protein Polyubiquitination Ubiquinone Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Response To Toxic Substance Removal Of Superoxide Radicals Protein Catabolic Process Response To Lipopolysaccharide Cellular Response To Oxidative Stress Negative Regulation Of Protein Catabolic Process Vitamin E Metabolic Process Vitamin K Metabolic Process Innate Immune Response Cell Redox Homeostasis Response To Caloric Restriction Negative Regulation Of Ferroptosis
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex TICAM1, RIP1-mediated IKK complex recruitment APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Signaling by BMP Downstream TCR signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Ovarian tumor domain proteases Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Aberrant regulation of mitotic exit in cancer due to RB1 defects Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Regulation of ornithine decarboxylase (ODC) NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		None	Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol ES-936 Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE Cannabidiol
GWAS		Brain imaging ( 20100581 ) Crohn's disease ( 21102463 )	Alcohol consumption (drinks per week) ( 30679032 ) Blood osmolality (transformed sodium) ( 28360221 ) Blood protein levels ( 30072576 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body mass index ( 26426971 ) Estimated glomerular filtration rate ( 31015462 ) Mean platelet volume ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Triglyceride levels ( 32203549 )
Interacting Genes		239 interacting genes: AMFR ANAPC11 ANXA1 ANXA7 AREL1 ARIH1 ARIH2 ARK2C ARRDC3 ASB2 ASB4 ASB9 BABAM2 BARD1 BFAR BIRC2 BIRC3 BIRC6 BIRC7 BIRC8 BRCA1 BRCC3 BRMS1 C7orf25 CADPS2 CBL CBLC CDK7 CDKN1A CHFR CNOT4 COP1 CRBN CREBBP CRYAB CTNNB1 CUL2 CUL3 CUL4A DTL DTX1 DTX2 DTX3 DTX3L DYRK2 DZIP3 EP300 EPS15 F12 FAF2 FBXL2 FBXL20 FBXO2 FBXO7 FOS FZR1 GADD45A GSK3B HDAC6 HECTD1 HECW1 HERC2 HERC3 HIF1A HSD17B10 HUWE1 ITCH KAT2B KCTD17 KDM2B KEAP1 KLHL13 KLHL2 KLHL9 LNPK LRR1 LRSAM1 LTN1 MAP3K1 MARCHF1 MARCHF2 MARCHF4 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEOX2 MGRN1 MIB1 MIB2 MID1 MID2 MKNK1 MKRN1 MKRN2 MKRN3 MUL1 NBN NEDD4 NEDD4L NEURL1 NFKBIA NHLRC1 NQO1 NR1H2 OBI1 PELI1 PJA2 PMAIP1 POLL POLM POLR2E PRKN RABGEF1 RAG1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF125 RNF126 RNF13 RNF130 RNF14 RNF144A RNF150 RNF166 RNF167 RNF168 RNF181 RNF182 RNF185 RNF2 RNF207 RNF216 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF43 RNF5 RNF6 RNF7 RNF8 SH3RF1 SHPRH SIAH1 SIAH2 SIRT6 SIVA1 SKP1 SMURF1 SPOP STAM2 STUB1 TAF1D TBL1X TMEM129 TNFAIP3 TNNT1 TOM1 TOPORS TRAF2 TRAF4 TRAF6 TRAF7 TRAIP TRIM10 TRIM17 TRIM21 TRIM22 TRIM23 TRIM24 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM35 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM69 TRIM7 TRIM72 TRIM8 TRIP12 TSC22D1 UBA1 UBA6 UBASH3B UBC UBE3A UBE3C UBE4A UBOX5 UBR5 UBTD1 UFM1 UHRF1 UHRF2 USP21 UVSSA VHL WWP1 WWP2 XIAP ZNF598 ZNRF1 ZNRF2 ZNRF4 ZRANB1	10 interacting genes: CDC42 DNAJB1 GALT HIF1A HSPA1A ING1 PRKN STUB1 TP53 UBE2D1
Entrez ID		7321	1728
HPRD ID		04267	00518
Ensembl ID		ENSG00000072401	ENSG00000181019
Uniprot IDs		A0A087WW00 P51668	B4DLR8 P15559
PDB IDs		2C4P 2YHO 3OJ4 3PTF 4AP4 4QPL 5FER 5TUT 6D4P 7ZJ3	1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4 6LLC 8C9J 8OK0 8PQN 8RFM 8RFN
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Macromolecule Catabolic Process Zinc Ion Binding Macromolecule Metabolic Process Proteolysis Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Metal Ion Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Cytoplasm Protein Monoubiquitination Response To Stress Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction DNA Damage Response Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding	Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Post-translational Protein Modification Protein-folding Chaperone Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Topologically Incorrect Protein Ubiquitin Protein Ligase Binding Regulation Of Growth Histone Deacetylase Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Cell Growth Enzyme Binding Hsp70 Protein Binding Regulation Of Mitophagy Protein-containing Complex Cellular Response To Heat Regulation Of Autophagy Of Mitochondrion Regulation Of Protein-containing Complex Assembly Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Positive Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Heat Shock Protein Binding Negative Regulation Of Apoptotic Process Negative Regulation Of Growth Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Protein Stabilization Regulation Of Programmed Cell Death Regulation Of Cellular Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Response To Heat