UBE2D1 and SIRT6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		UBE2D1	SIRT6
Description		ubiquitin conjugating enzyme E2 D1	sirtuin 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Endoplasmic Reticulum Site Of Double-strand Break Site Of DNA Damage Chromosome, Subtelomeric Region
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	DNA Binding Chromatin Binding Damaged DNA Binding Transcription Corepressor Activity RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Deacetylase Activity, NAD-dependent Enzyme Regulator Activity Chromatin DNA Binding Nucleosome Binding Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism NAD-dependent Protein Lysine Deacetylase Activity Histone Deacetylase Regulator Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Deacetylase Activity, NAD-dependent NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD+-protein-arginine ADP-ribosyltransferase Activity DNA Damage Sensor Activity Histone H3K56 Deacetylase Activity, NAD-dependent NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity TORC2 Complex Binding NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Negative Regulation Of TORC1 Signaling	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Base-excision Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling Protein Deacetylation Protein Import Into Nucleus Inflammatory Response DNA Damage Response Ras Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Response To UV Transposable Element Silencing Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Lipid Metabolic Process Pericentric Heterochromatin Formation Subtelomeric Heterochromatin Formation Protein Destabilization Positive Regulation Of Insulin Secretion Positive Regulation Of Telomere Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Transcription Elongation By RNA Polymerase II Ketone Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Glucose Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Regulation Of Protein Secretion Regulation Of Lipid Catabolic Process Protein Delipidation Cardiac Muscle Cell Differentiation Protein Poly-ADP-ribosylation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling Transcription Pausing By RNA Polymerase II Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Chondrocyte Proliferation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Protein Localization To Site Of Double-strand Break Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex TICAM1, RIP1-mediated IKK complex recruitment APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Signaling by BMP Downstream TCR signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Ovarian tumor domain proteases Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Aberrant regulation of mitotic exit in cancer due to RB1 defects Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Brain imaging ( 20100581) Crohn's disease ( 21102463)
Interacting Genes		239 interacting genes: AMFR ANAPC11 ANXA1 ANXA7 AREL1 ARIH1 ARIH2 ARK2C ARRDC3 ASB2 ASB4 ASB9 BABAM2 BARD1 BFAR BIRC2 BIRC3 BIRC6 BIRC7 BIRC8 BRCA1 BRCC3 BRMS1 C7orf25 CADPS2 CBL CBLC CDK7 CDKN1A CHFR CNOT4 COP1 CRBN CREBBP CRYAB CTNNB1 CUL2 CUL3 CUL4A DTL DTX1 DTX2 DTX3 DTX3L DYRK2 DZIP3 EP300 EPS15 F12 FAF2 FBXL2 FBXL20 FBXO2 FBXO7 FOS FZR1 GADD45A GSK3B HDAC6 HECTD1 HECW1 HERC2 HERC3 HIF1A HSD17B10 HUWE1 ITCH KAT2B KCTD17 KDM2B KEAP1 KLHL13 KLHL2 KLHL9 LNPK LRR1 LRSAM1 LTN1 MAP3K1 MARCHF1 MARCHF2 MARCHF4 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEOX2 MGRN1 MIB1 MIB2 MID1 MID2 MKNK1 MKRN1 MKRN2 MKRN3 MUL1 NBN NEDD4 NEDD4L NEURL1 NFKBIA NHLRC1 NQO1 NR1H2 OBI1 PELI1 PJA2 PMAIP1 POLL POLM POLR2E PRKN RABGEF1 RAG1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF125 RNF126 RNF13 RNF130 RNF14 RNF144A RNF150 RNF166 RNF167 RNF168 RNF181 RNF182 RNF185 RNF2 RNF207 RNF216 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF43 RNF5 RNF6 RNF7 RNF8 SH3RF1 SHPRH SIAH1 SIAH2 SIRT6 SIVA1 SKP1 SMURF1 SPOP STAM2 STUB1 TAF1D TBL1X TMEM129 TNFAIP3 TNNT1 TOM1 TOPORS TRAF2 TRAF4 TRAF6 TRAF7 TRAIP TRIM10 TRIM17 TRIM21 TRIM22 TRIM23 TRIM24 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM35 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM69 TRIM7 TRIM72 TRIM8 TRIP12 TSC22D1 UBA1 UBA6 UBASH3B UBC UBE3A UBE3C UBE4A UBOX5 UBR5 UBTD1 UFM1 UHRF1 UHRF2 USP21 UVSSA VHL WWP1 WWP2 XIAP ZNF598 ZNRF1 ZNRF2 ZNRF4 ZRANB1	18 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 DDB2 ELF5 FAF1 H3C1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A VIM
Entrez ID		7321	51548
HPRD ID		04267	12093
Ensembl ID		ENSG00000072401	ENSG00000077463
Uniprot IDs		A0A087WW00 P51668	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		2C4P 2YHO 3OJ4 3PTF 4AP4 4QPL 5FER 5TUT 6D4P 7ZJ3	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY 6QCD 6QCE 6QCH 6QCJ 6XUY 6XV1 6XV6 6XVG 6ZU4 7CL0 7CL1 8AK5 8AK6 8AK7 8AK8 8AK9 8AKA 8AKB 8AKC 8AKD 8AKE 8AKF 8AKG 8BL0 8BL1 8CNM 8CNO 8F86 8G57 8I2B 8OF4 9G7H
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Macromolecule Catabolic Process Zinc Ion Binding Macromolecule Metabolic Process Proteolysis Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Metal Ion Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Cytoplasm Protein Monoubiquitination Response To Stress Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction DNA Damage Response Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding	Nucleus Nucleoplasm Protein Polyubiquitination Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Protein Metabolic Process DNA Damage Response DNA Repair Checkpoint Clamp Complex Positive Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Meiotic Cell Cycle Checkpoint Signaling Positive Regulation Of Protein Modification Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Reproductive Process Damaged DNA Binding DNA N-glycosylase Activity Protein Modification By Small Protein Conjugation Protein Autoubiquitination Positive Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Ubiquitin-protein Transferase Activity Base-excision Repair, AP Site Formation Regulation Of TORC1 Signaling Post-translational Protein Modification Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Regulation Of DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process DNA Modification Regulation Of Protein Polyubiquitination Negative Regulation Of Cell Cycle Response To Stress
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